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高文运老师介绍
高文运博士，1992年7月在兰州大学化学系获硕士学位，1998年7月在中国科学院上海药物研究所获博士学位，其后在中国科学院上海有机化学研究所从事博士后研究；2000年9月赴德国马丁-路德大学生物中心从事萜类化合物的生物合成研究，2001年获洪堡基金支持继续从事相关研究，其间发现并建立了萜类化合物DXP/MEP生物合成途径中的一个重要中间体，所做的工作主要发表在 Angewandte Chemie Int. Ed. 及 Plant Physiology 等专业期刊上；2003年底转入美国犹他大学化学系从事萜类化合物生物合成过程中链增长反应机理的研究，取得重要阶段性研究成果；2006年7月回国，现任西北大学生命科学学院教授。目前已在SCI收录期刊上发表近二十篇论文，承担国家自然科学基金一项。
科研兴趣：
1,萜类化合物生物合成研究；
2,中草药有效成分的提取分离,结构鉴定及活性研究；
3,活性天然化合物的合成研究。
目前主持科研项目：
萜类化合物DXP/MEP生物合成途径中的中间体转化过程及亚合成途径的研究，国家自然科学基金，项目编号：20772095
近期发表论文：
Wenyun Gao, Yimin Li, Shanhao Jiang, Dayuan Zhu, Two lycopodium alkaloid N-oxides from Huperzia serrata, Helvetica Chimica Acta, 2008, 91, in press.
Wenyun Gao, Reik Loeser, Maja Raschke, Marco A. Dessoy, Michael Fulhorst, Henriette Alpermann, Ludger A. Wessjohann, Meinhart H. Zenk, (E)-4-Hydroxy-3-methylbut-2-enyl diphosphate: an intermediate in the formation of terpenoids in plant chromoplasts. Angewandte Chemie, International Edition, 2002, 41, 2604-2607.??
U.-I. Flügge, Wenyun Gao, Transport of Isoprenoid Intermediates Across Chloroplast Envelope Membranes, Plant Biol (Stuttg) 2005, 7, 91-97.??
Gao, Wenyun; Raschke, Maja; Alpermann, Henriette; Zenk, Meinhart H. A facile enzymatic synthesis of isotopically labeled 2-methyl-D-erythritol 2, 4-cyclo-diphosphate by spinach chloroplast stroma. Helvetica Chimica Acta, 2003, 86, 3568-3577.???
Jonathan E. Page, Gerd Hause, Maja Raschke, Wenyun Gao, Juergen Schmidt, Meinhart H. Zenk, and Toni M. Kutchan, Functional Analysis of the Final Steps of the 1-Deoxy-D-xylulose 5-phosphate (DXP) Pathway to Isoprenoids in Plants Using Virus-Induced Gene Silencing, Plant Physiology,2004, 134, 1401–1413.??
Brandt, Wolfgang; Dessoy, Marco A.; Fulhorst, Michael; Gao, Wenyun; Zenk, Meinhart H.; Wessjohann, Ludger A.? A proposed mechanism for the reductive ring opening of the cyclodiphosphate mecpp, a crucial transformation in the new DXP/MEP pathway to isoprenoids based on modeling studies and feeding experiments. ChemBioChem, 2004, 311-323.
Wenyun Gao, Yimin Li, Shanhao Jiang, Dayuan Zhu, Three lycopodium alkaloid N-oxides from Huperzia serrata, Planta Med. 2000, 66: 664. ??
Wenyun Gao, Yimin Li, Shanhao Jiang, Dayuan Zhu, A new lycopodium alkaloid from the whole plants of Huperzia serrata, Chin. J. Chem. 2000, 18: 614.
Wenyun Gao, Yimin Li, Dayuan Zhu, Phenylic glycosides and g-lactone glycoside from the sprouts of Crocus sativus,, Planta Med. 1999, 65: 425.
Wenyun Gao, Yimin Li, Baode Wang, Dayuan Zhu, Huperzine h, a new lycopodium alkaloid from Huperzia serrata, Chin. Chem. Lett., 1999, 10: 463.
Wenyun Gao, Yimin Li, Dayuan Zhu, New anthraquinones from the sprouts of Crocus sativus, 植物学报，1999, 41: 531.
Yimin Li, Shanhao Jiang, Wenyun Gao, Dayuan Zhu, Iridoid glycosides from Scrophularia ningpoensis, Phytochemistry, 1999, 50: 101.
Yimin Li, Shanhao Jiang, Wenyun Gao, Dayuan Zhu, Phenylpropanoid glycosides from Scrophularia ningpoensis, Phytochemistry, 2000, 54: 923.
科研兴趣：
1,萜类化合物生物合成研究；
2,中草药有效成分的提取分离,结构鉴定及活性研究；
3,活性天然化合物的合成研究。
目前主持科研项目：
萜类化合物DXP/MEP生物合成途径中的中间体转化过程及亚合成途径的研究，国家自然科学基金，项目编号：20772095
近期发表论文：
Wenyun Gao, Yimin Li, Shanhao Jiang, Dayuan Zhu, Two lycopodium alkaloid N-oxides from Huperzia serrata, Helvetica Chimica Acta, 2008, 91, in press.
Wenyun Gao, Reik Loeser, Maja Raschke, Marco A. Dessoy, Michael Fulhorst, Henriette Alpermann, Ludger A. Wessjohann, Meinhart H. Zenk, (E)-4-Hydroxy-3-methylbut-2-enyl diphosphate: an intermediate in the formation of terpenoids in plant chromoplasts. Angewandte Chemie, International Edition, 2002, 41, 2604-2607.??
U.-I. Flügge, Wenyun Gao, Transport of Isoprenoid Intermediates Across Chloroplast Envelope Membranes, Plant Biol (Stuttg) 2005, 7, 91-97.??
Gao, Wenyun; Raschke, Maja; Alpermann, Henriette; Zenk, Meinhart H. A facile enzymatic synthesis of isotopically labeled 2-methyl-D-erythritol 2, 4-cyclo-diphosphate by spinach chloroplast stroma. Helvetica Chimica Acta, 2003, 86, 3568-3577.???
Jonathan E. Page, Gerd Hause, Maja Raschke, Wenyun Gao, Juergen Schmidt, Meinhart H. Zenk, and Toni M. Kutchan, Functional Analysis of the Final Steps of the 1-Deoxy-D-xylulose 5-phosphate (DXP) Pathway to Isoprenoids in Plants Using Virus-Induced Gene Silencing, Plant Physiology,2004, 134, 1401–1413.??
Brandt, Wolfgang; Dessoy, Marco A.; Fulhorst, Michael; Gao, Wenyun; Zenk, Meinhart H.; Wessjohann, Ludger A.? A proposed mechanism for the reductive ring opening of the cyclodiphosphate mecpp, a crucial transformation in the new DXP/MEP pathway to isoprenoids based on modeling studies and feeding experiments. ChemBioChem, 2004, 311-323.
Wenyun Gao, Yimin Li, Shanhao Jiang, Dayuan Zhu, Three lycopodium alkaloid N-oxides from Huperzia serrata, Planta Med. 2000, 66: 664. ??
Wenyun Gao, Yimin Li, Shanhao Jiang, Dayuan Zhu, A new lycopodium alkaloid from the whole plants of Huperzia serrata, Chin. J. Chem. 2000, 18: 614.
Wenyun Gao, Yimin Li, Dayuan Zhu, Phenylic glycosides and g-lactone glycoside from the sprouts of Crocus sativus,, Planta Med. 1999, 65: 425.
Wenyun Gao, Yimin Li, Baode Wang, Dayuan Zhu, Huperzine h, a new lycopodium alkaloid from Huperzia serrata, Chin. Chem. Lett., 1999, 10: 463.
Wenyun Gao, Yimin Li, Dayuan Zhu, New anthraquinones from the sprouts of Crocus sativus, 植物学报，1999, 41: 531.
Yimin Li, Shanhao Jiang, Wenyun Gao, Dayuan Zhu, Iridoid glycosides from Scrophularia ningpoensis, Phytochemistry, 1999, 50: 101.
Yimin Li, Shanhao Jiang, Wenyun Gao, Dayuan Zhu, Phenylpropanoid glycosides from Scrophularia ningpoensis, Phytochemistry, 2000, 54: 923.
高文运老师相关教学资源
- 西北大学教学资源
- 高文运老师课程教学资源
