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魏垒老师介绍
魏垒，博士，著名骨关节病专家，骨科特聘客座教授，在国际著名关节期刊发表论文近几30篇，现就职于美国罗德岛州布朗大学医学院。主要研究方向：骨关节的防治。其简历与近年主要成果如下：
BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
Lei Wei POSITION TITLE
Research Assistant Professor
eRA COMMONS USER NAME
WeiLei01
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION DEGREE
(if applicable) YEAR(s) FIELD OF STUDY
Guiyang Medical College, China M.D. 1983 Medicine
Karolinska Institute, Stockholm, Sweden Ph.D. 1999 Osteoarthritis
Penn State University College of Medicine, PA Post-Doc 1999-2002 Molecular Biology
A. Positions and Honors.
Position and Employment
1983-1994: Researcher / Lecturer, Dept. of Orthopedics, Affiliated Hospital of Guiyang Medical College, China
1994-1999: Ph.D. candidate, Dept. of Orthopedics, Huddinge University Hospital, Karolinska Institute, Sweden
1999-2002: Post-doctoral Fellow, Dept. of Orthopedics, Penn State College of Medicine, Hershey, PA
2002-present: Research Associate, Rhode Island Hospital, Providence, RI
2004-present: Research Assistant Professor, Brown Medical School, Providence, RI
Other Experience and Professional Memberships
1999- current: Orthopaedic Research Society Active member.
2001- current: International Chinese Hard Tissue Society (ICHTS).
Honors
Visiting Scholarship, China Education foundation (1994-1995).
Research Fellowship, Shrine Hospital for Children (1999-2001).
New Investigator Recognition Awards, Orthopaedic Research Society (2001)
Young Investigator Award, Osteoarthritis Research Society International (OARSI) (2002)
Young Investigator Award, Osteoarthritis Research Society International (OARSI) (2005)
Young Investigator Award Winner, NIH 2nd Biennial National IDeA Symposium of Biomedical research Excellence (NISBRE). August 6-8, 2008, Washington DC
Webster Jee Travel Awards. International Conference on Osteoporosis and Bone Research (ICOBR). Oct. 22-25, 2008 in Beijing, China.
Best Paper Award on 2008 International Conference on Osteoporosis and Bone Research Oct. 22-25, 2008 in Beijing, China.
B. Selected peer-reviewed publications (in chronological order).
1. Wei, L., Svensson, O, and Hjerpe, A. Articular cartilage proteoglycans during development of primary osteoarthrosis in the guinea pig. Acta Orthop Scand (suppl 270) 1996; 67:63.
2. Yu Yanni and Wei Lei. Effect of vitamin C on the joint synovial cells in the experimental fluorosis rats with stereological method. China comprehensive medicine. 1996: 3: 41-43.
3. Edin de Bri, Wei, L., Finn P Reinholt, Silwa MW, Dick Heinegard, and Svensson, O. Ultrastructural immunolocalization of bone sioloprotein in guinea pig osteoarthrosis. Osteoarthritis and Cartilage. 1997; 5 (6): 387-393.
4. Wei, L., Svensson, O. and Hjerpe, A. Correlation of Morphological and Biochemical Changes in the Natural History of the Spontaneous Osteoarthrosis in Guinea Pigs. Arthritis Rheumatism. 1997: 40 (11): 2075-2083.
5. Wei, L., Hjerpe, A., and Svensson, O. Structural and biochemical changes in guinea pig osteoarthritis after surgically altered load. Acta orthopaedica Scandinavica Supplementum. 1998; 280 (69): 24.
6. Wei, L., Hjerpe, A., and Svensson, O. Proteoglycan turnover during development of spontaneous osteoarthrosis in guinea pig. Acta Orthopaedica Scandinavica Supplementum. 1998; 280 (69):23.
7. Edin de Bri, Wei, Lei, Olle Svesson, majeed Chowdhury, Susan A Mooak, and Robert A Greenwald. Effect of an inhibitor of matrix metalloproteinases on spontaneous osteoarthritis in guinea pigs. Dental Research 1998;vol12:82-85.
8. Wei, L., Svensson, O., and Hjerpe, A. Metabolic Turnover of Sulfated Glycosaminoglycans and Proteoglycans in Guinea Pigs Knee Articular Cartilage during Development of Primary Osteoarthrosis. Osteoarthritis and Cartilage. 1998; 6 (6): 410-416.
9. Wei, L., Lundberg, A., and Svensson, O. Mechanical Load and Primary Guinea Pig Osteoarthrosis. Acta Scandinavica Orthopadica. 1998; 69 (4): 351-357.
10. LP Zou, DH Ma, L Wei, van der Meide PH, Mix Eilhard and J Zhu. IFN-b suppresses experimental autoimmune neuritis in Lewis rats by inhibiting the migration of inflammatory cells into peripheral nervous tissue. J Neuroscience Research. 1999; 56: 123-130.
11. LP Zou, DH Ma, M Levi, B Wahren, BG Xiao, L Wei, E Mix, van der Meide PH, J Zhu. Antigenspecific immunosuppression: nasal tolerance of P0 protein peptides for the prevention and treatment of experimental autoimmune neuritis in Lewis rats. Journal of Neuroimmunology. 1999; 94: 109-121.
12. Wei, L. Guinea Pig Osteoarthritis-Morphological and Biochemical Studies. Printed in Sweden by Repro Print AB, Stockholm 1999: 2. ISBN 91-628-3361-8.
13. Edin de Bri and Wei, Lei. Biochemical and histological effects of tetracyclines on spontaneous osteoarthritis in guinea pigs. Image Anal Stereol 2000;19:125-131.
14. Xuechu Zhen, Lei Wei, Qiuqian Wu, Yue Zhang, and Qian Chen. Mitogen-Activated Protein Kinase p38 Mediates Regulation of Chondrocyte Differentiation by Parathyroid Hormone. Journal of Biological Chemistry 2001; 276(7): 4879-4885.
15. Wei, L., Hjerpe, A., and Svensson, O. The effect of load on articular cartilage matrix and the developmentof guinea-pig osteoarthritis. Osteoarthritis and Cartilage 2001; 9(5): 447-53.
16. Wei, L., Hultenby K, Hjerpe, A. Brismar H and Svensson, O. Distribution of chondroitin 4-sulfate epitopes (2/B/6) in spontaneous guinea pig osteoarthrosis. Acta Scandinavica Orthopadica. 2003; 74(1): 16-21.
17. Brismar BH, Wei L, Hjerpe A, Svensson O. The effect of body mass and physical activity on the development of guinea pig osteoarthrosis. Acta Orthop Scand. 2003; 74(4): 442-8.
18. Chen, Q., Lei, W., Wang, Z., Sun, X., Luo, J., and Yang, X. Endochondral bone formation and extracellular matrix, Current Topics in Bone Biology, 145-162, Deng, H., and Liu, Y. (Eds) World Scientific Publishing Co. 2005.
19. Sun X, Wei L, Liden J, Hui G, Dahlman-Wright K, Hjerpe A, Dobra K. Molecular characterization of tumour heterogeneity and malignant mesothelioma cell differentiation by gene profiling. J Pathol. 2005 Jul 8;207(1):91-101.
20. Wei L, Sun X, Terek R, Chen Q. Down-Regulation of A Chemokine Receptor CXCR4 by Small Interfering RNA Inhibits MMP13 Release and Enhances TIMP 1 Expression in Articular Chondrocytes. Osteoarthritis and Cartilage 2005; 13: Supplement A S29.
21. Wei L, Sun X, Terek R, Chen Q. CD95 induced osteoarthritic chondrocytes apoptosis and necrosis: dependency on p38 mitogen-activated protein kinase. Arthritis Research & Therapy 2006; 8(2);R37.
22. Lei Wei, Xiaojuan Sun, Zhengke Wang, Changqi Sun, Katsuaki Kanbe*, Richard Terek and Qian Chen. Chondrocyte Death Induced by Pathological Concentration of Chemokine Stromal Cell-Derived Factor-1. The Journal of Rheumatology. 2006; 33(9): 1818-26.
23. van der Weyden, L., Wei, L, Luo, J., Yang, X., Birk, D. E., Adams, D. J., Bradley, A., and Chen, Q. Functional knockout of the matrilin-3 gene causes premature chondrocyte maturation to hypertrophy and increases bone mineral density and osteoarthritis, American Journal of Pathology, 169(2): 515-527, 2006.
24. Katsuaki Kanbe; Lei Wei; Changqi Sun; Qian Chen. Pericellular Matrilins Regulate Activation of Chondrocytes by Cyclic Load-Induced Matrix Deformation. The Journal of Bone and Mineral Research. 2007;22:318-328.
25. Surena Namdari, M.D., Lei Wei, M.D., Ph.D., Douglas Moore, M.S., and Qian Chen, Ph.D. Genetic Inhibition of P38 MAP Kinase Activity in Cartilage Reduces Limb Length and Worsens Osteoarthritis in Adult Mice. Arthritis Rheumatism 2008 Accepted.
26. Yan-lin Li, Rui Han, Xue-ling Zhao, Xiao-guang Xiu, Lei Wei. A novel biphasic porous bioceramic derived from sintered porcine bone and cytocompatibility evaluation with bone marrow mesynchmal stem cells. Submit to Journal of Biomedical Materials Research. 2008.
27. Yan-lin Li, Rui Han, Xue-ling Zhao, Xiao-guang Xiu, Hong-tao Guo,Yong-nian Wang, Lei Wei. A New Osteonecrosis Animal Model of The Femoral Head Induced by Microwave Heating and Repaired With Tissue Engineered Bone. International Orthopaedics. Tuesday, October 28, 2008 (Publish Online).
28. Ming Pei, Fan He, Ashley Rawson and Lei Wei. Melatonin enhances chondrogenic differentiation of porcine articular chondrocytes. J Pineal Res. 2008Accepted 2008.
29. Joseph K. Lee, Ming Pei, Lei Wei. The Protective Role of Insulin-like Growth Factor1 in Osteoarthritis – A Guinea-pig model. Submit to Journal of bone and joint surgery. 2008
30. Lei Wei, Braden C. Fleming, Xiaojuan Sun, Erin Teeple, Wesley Wu, Gregory D. Jay, Khaled A. Elsaid, Jason T. Machan, Qian Chen. A Comparison of Differential Biomarkers of Osteoarthritis with and without Post-traumatic Injury in the Hartley Guinea Pig Model. Submit to Osteoarthritis and Cartilage 2008
C. Research Support
Ongoing Research Support
NIH/NIAMS (Lei Wei) 1R03 AR052479-01A1, 04/01/2006-03/31/2009.
Principal Investigator, Chemokin Regulation of Cartilage Matrix Resorption.
Aircast Foundation (Lei Wei), 03/01/08-02/28/2010
Principal Investigator, Disruption of SDF-1 signaling inhibits cartilage degeneration and attenuates osteoarthritis pathogenesis
NIH/ NCRR (Qian Chen) 1P20RR024484-01, 09/15/2007-07/31/2012.
Principal Investigator for Mechanism of Growth Plate Development Regulated by HDAC4(one of five projects, Dr. Qian Chen as director for this COBRE project).
RIH Orthopedic Foundation (Lei Wei), 09/15/2008-07/31/2010.The Pathology Process of the Post-Traumatic OA Model is Different from the Naturally Developed OA model in Guinea Pigs.
Pending Applications
BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
Lei Wei POSITION TITLE
Research Assistant Professor
eRA COMMONS USER NAME
WeiLei01
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION DEGREE
(if applicable) YEAR(s) FIELD OF STUDY
Guiyang Medical College, China M.D. 1983 Medicine
Karolinska Institute, Stockholm, Sweden Ph.D. 1999 Osteoarthritis
Penn State University College of Medicine, PA Post-Doc 1999-2002 Molecular Biology
A. Positions and Honors.
Position and Employment
1983-1994: Researcher / Lecturer, Dept. of Orthopedics, Affiliated Hospital of Guiyang Medical College, China
1994-1999: Ph.D. candidate, Dept. of Orthopedics, Huddinge University Hospital, Karolinska Institute, Sweden
1999-2002: Post-doctoral Fellow, Dept. of Orthopedics, Penn State College of Medicine, Hershey, PA
2002-present: Research Associate, Rhode Island Hospital, Providence, RI
2004-present: Research Assistant Professor, Brown Medical School, Providence, RI
Other Experience and Professional Memberships
1999- current: Orthopaedic Research Society Active member.
2001- current: International Chinese Hard Tissue Society (ICHTS).
Honors
Visiting Scholarship, China Education foundation (1994-1995).
Research Fellowship, Shrine Hospital for Children (1999-2001).
New Investigator Recognition Awards, Orthopaedic Research Society (2001)
Young Investigator Award, Osteoarthritis Research Society International (OARSI) (2002)
Young Investigator Award, Osteoarthritis Research Society International (OARSI) (2005)
Young Investigator Award Winner, NIH 2nd Biennial National IDeA Symposium of Biomedical research Excellence (NISBRE). August 6-8, 2008, Washington DC
Webster Jee Travel Awards. International Conference on Osteoporosis and Bone Research (ICOBR). Oct. 22-25, 2008 in Beijing, China.
Best Paper Award on 2008 International Conference on Osteoporosis and Bone Research Oct. 22-25, 2008 in Beijing, China.
B. Selected peer-reviewed publications (in chronological order).
1. Wei, L., Svensson, O, and Hjerpe, A. Articular cartilage proteoglycans during development of primary osteoarthrosis in the guinea pig. Acta Orthop Scand (suppl 270) 1996; 67:63.
2. Yu Yanni and Wei Lei. Effect of vitamin C on the joint synovial cells in the experimental fluorosis rats with stereological method. China comprehensive medicine. 1996: 3: 41-43.
3. Edin de Bri, Wei, L., Finn P Reinholt, Silwa MW, Dick Heinegard, and Svensson, O. Ultrastructural immunolocalization of bone sioloprotein in guinea pig osteoarthrosis. Osteoarthritis and Cartilage. 1997; 5 (6): 387-393.
4. Wei, L., Svensson, O. and Hjerpe, A. Correlation of Morphological and Biochemical Changes in the Natural History of the Spontaneous Osteoarthrosis in Guinea Pigs. Arthritis Rheumatism. 1997: 40 (11): 2075-2083.
5. Wei, L., Hjerpe, A., and Svensson, O. Structural and biochemical changes in guinea pig osteoarthritis after surgically altered load. Acta orthopaedica Scandinavica Supplementum. 1998; 280 (69): 24.
6. Wei, L., Hjerpe, A., and Svensson, O. Proteoglycan turnover during development of spontaneous osteoarthrosis in guinea pig. Acta Orthopaedica Scandinavica Supplementum. 1998; 280 (69):23.
7. Edin de Bri, Wei, Lei, Olle Svesson, majeed Chowdhury, Susan A Mooak, and Robert A Greenwald. Effect of an inhibitor of matrix metalloproteinases on spontaneous osteoarthritis in guinea pigs. Dental Research 1998;vol12:82-85.
8. Wei, L., Svensson, O., and Hjerpe, A. Metabolic Turnover of Sulfated Glycosaminoglycans and Proteoglycans in Guinea Pigs Knee Articular Cartilage during Development of Primary Osteoarthrosis. Osteoarthritis and Cartilage. 1998; 6 (6): 410-416.
9. Wei, L., Lundberg, A., and Svensson, O. Mechanical Load and Primary Guinea Pig Osteoarthrosis. Acta Scandinavica Orthopadica. 1998; 69 (4): 351-357.
10. LP Zou, DH Ma, L Wei, van der Meide PH, Mix Eilhard and J Zhu. IFN-b suppresses experimental autoimmune neuritis in Lewis rats by inhibiting the migration of inflammatory cells into peripheral nervous tissue. J Neuroscience Research. 1999; 56: 123-130.
11. LP Zou, DH Ma, M Levi, B Wahren, BG Xiao, L Wei, E Mix, van der Meide PH, J Zhu. Antigenspecific immunosuppression: nasal tolerance of P0 protein peptides for the prevention and treatment of experimental autoimmune neuritis in Lewis rats. Journal of Neuroimmunology. 1999; 94: 109-121.
12. Wei, L. Guinea Pig Osteoarthritis-Morphological and Biochemical Studies. Printed in Sweden by Repro Print AB, Stockholm 1999: 2. ISBN 91-628-3361-8.
13. Edin de Bri and Wei, Lei. Biochemical and histological effects of tetracyclines on spontaneous osteoarthritis in guinea pigs. Image Anal Stereol 2000;19:125-131.
14. Xuechu Zhen, Lei Wei, Qiuqian Wu, Yue Zhang, and Qian Chen. Mitogen-Activated Protein Kinase p38 Mediates Regulation of Chondrocyte Differentiation by Parathyroid Hormone. Journal of Biological Chemistry 2001; 276(7): 4879-4885.
15. Wei, L., Hjerpe, A., and Svensson, O. The effect of load on articular cartilage matrix and the developmentof guinea-pig osteoarthritis. Osteoarthritis and Cartilage 2001; 9(5): 447-53.
16. Wei, L., Hultenby K, Hjerpe, A. Brismar H and Svensson, O. Distribution of chondroitin 4-sulfate epitopes (2/B/6) in spontaneous guinea pig osteoarthrosis. Acta Scandinavica Orthopadica. 2003; 74(1): 16-21.
17. Brismar BH, Wei L, Hjerpe A, Svensson O. The effect of body mass and physical activity on the development of guinea pig osteoarthrosis. Acta Orthop Scand. 2003; 74(4): 442-8.
18. Chen, Q., Lei, W., Wang, Z., Sun, X., Luo, J., and Yang, X. Endochondral bone formation and extracellular matrix, Current Topics in Bone Biology, 145-162, Deng, H., and Liu, Y. (Eds) World Scientific Publishing Co. 2005.
19. Sun X, Wei L, Liden J, Hui G, Dahlman-Wright K, Hjerpe A, Dobra K. Molecular characterization of tumour heterogeneity and malignant mesothelioma cell differentiation by gene profiling. J Pathol. 2005 Jul 8;207(1):91-101.
20. Wei L, Sun X, Terek R, Chen Q. Down-Regulation of A Chemokine Receptor CXCR4 by Small Interfering RNA Inhibits MMP13 Release and Enhances TIMP 1 Expression in Articular Chondrocytes. Osteoarthritis and Cartilage 2005; 13: Supplement A S29.
21. Wei L, Sun X, Terek R, Chen Q. CD95 induced osteoarthritic chondrocytes apoptosis and necrosis: dependency on p38 mitogen-activated protein kinase. Arthritis Research & Therapy 2006; 8(2);R37.
22. Lei Wei, Xiaojuan Sun, Zhengke Wang, Changqi Sun, Katsuaki Kanbe*, Richard Terek and Qian Chen. Chondrocyte Death Induced by Pathological Concentration of Chemokine Stromal Cell-Derived Factor-1. The Journal of Rheumatology. 2006; 33(9): 1818-26.
23. van der Weyden, L., Wei, L, Luo, J., Yang, X., Birk, D. E., Adams, D. J., Bradley, A., and Chen, Q. Functional knockout of the matrilin-3 gene causes premature chondrocyte maturation to hypertrophy and increases bone mineral density and osteoarthritis, American Journal of Pathology, 169(2): 515-527, 2006.
24. Katsuaki Kanbe; Lei Wei; Changqi Sun; Qian Chen. Pericellular Matrilins Regulate Activation of Chondrocytes by Cyclic Load-Induced Matrix Deformation. The Journal of Bone and Mineral Research. 2007;22:318-328.
25. Surena Namdari, M.D., Lei Wei, M.D., Ph.D., Douglas Moore, M.S., and Qian Chen, Ph.D. Genetic Inhibition of P38 MAP Kinase Activity in Cartilage Reduces Limb Length and Worsens Osteoarthritis in Adult Mice. Arthritis Rheumatism 2008 Accepted.
26. Yan-lin Li, Rui Han, Xue-ling Zhao, Xiao-guang Xiu, Lei Wei. A novel biphasic porous bioceramic derived from sintered porcine bone and cytocompatibility evaluation with bone marrow mesynchmal stem cells. Submit to Journal of Biomedical Materials Research. 2008.
27. Yan-lin Li, Rui Han, Xue-ling Zhao, Xiao-guang Xiu, Hong-tao Guo,Yong-nian Wang, Lei Wei. A New Osteonecrosis Animal Model of The Femoral Head Induced by Microwave Heating and Repaired With Tissue Engineered Bone. International Orthopaedics. Tuesday, October 28, 2008 (Publish Online).
28. Ming Pei, Fan He, Ashley Rawson and Lei Wei. Melatonin enhances chondrogenic differentiation of porcine articular chondrocytes. J Pineal Res. 2008Accepted 2008.
29. Joseph K. Lee, Ming Pei, Lei Wei. The Protective Role of Insulin-like Growth Factor1 in Osteoarthritis – A Guinea-pig model. Submit to Journal of bone and joint surgery. 2008
30. Lei Wei, Braden C. Fleming, Xiaojuan Sun, Erin Teeple, Wesley Wu, Gregory D. Jay, Khaled A. Elsaid, Jason T. Machan, Qian Chen. A Comparison of Differential Biomarkers of Osteoarthritis with and without Post-traumatic Injury in the Hartley Guinea Pig Model. Submit to Osteoarthritis and Cartilage 2008
C. Research Support
Ongoing Research Support
NIH/NIAMS (Lei Wei) 1R03 AR052479-01A1, 04/01/2006-03/31/2009.
Principal Investigator, Chemokin Regulation of Cartilage Matrix Resorption.
Aircast Foundation (Lei Wei), 03/01/08-02/28/2010
Principal Investigator, Disruption of SDF-1 signaling inhibits cartilage degeneration and attenuates osteoarthritis pathogenesis
NIH/ NCRR (Qian Chen) 1P20RR024484-01, 09/15/2007-07/31/2012.
Principal Investigator for Mechanism of Growth Plate Development Regulated by HDAC4(one of five projects, Dr. Qian Chen as director for this COBRE project).
RIH Orthopedic Foundation (Lei Wei), 09/15/2008-07/31/2010.The Pathology Process of the Post-Traumatic OA Model is Different from the Naturally Developed OA model in Guinea Pigs.
Pending Applications
魏垒老师相关教学资源
