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彭师奇老师介绍
姓名：彭师奇 性别：男 职称：教授
职务：院长 招生院所：化学生物学与药学院
招生类型：科学学位(博) 科学学位(硕)
招生专业：神经生物学(博) 药物化学(硕)
研究方向名称：氨基酸的杂环先导结构的研究
电子信箱：
社会任职
个人简历
重要学术论文
1. Ming Zhao, Xin Jia, Chao Wang, Qin Li, Kexiang Zhou, Lili Wang, Hu Liu and Shiqi Peng*.PAK: An Essential Motif for Forming β-Turn Structures and Exhibiting Thrombolytic Effect for P6A and Its Analogs. Biochem. Cell Biol.. 2007,85:730-740.SCI
2. Jianghui Wu, Guohui Cui, Ming Zhao, Chunying Cui, & Shiqi Peng*.Novel N-(3-Carboxyl-9-benzylcarboline-1-yl)ethylamino Acids: Synthesis, Anti-proliferation Activities and Two Step Course of Intercalation Toward Calf Thymus DNA. Molecular BioSystems. 2007,3:855-861.SCI
3. Ming Zhao, Zheng Li, Li Peng, Yu-Rong Tang, Chao Wang, Ziding Zhang, Shiqi Peng*.Novel 1-Oxyl-2-substitutedphenyl-4,4,5,5-tetramethylimidazolines: Synthesis, Selectively Analgesic Action and QSAR analysis. Bioorg. Med. Chem.. 2007,15:2815-2826.SCI
4. Guofeng Wu, Lanrong Bi, Ming Zhao, Chao Wang, Michèle Baudy-Floc’h , Jingfang Ju, Shiqi Peng*.Toward Breast Cancer Resistance Protein (BCRP) Inhibitors: Design, Synthesis of A Series of New Simplified Fumitremorgin C Analogues. Tetrahedron. 2007,63:5510-5528.SCI
5. Yuji Wang, Lanrong Bi, Baoguang Hou, Yu Chen, Ming Zhao, Chao Wang, Wei Wang, Jingfang Ju,| Shiqi Peng*. Design and Synthesis of Pentahydroxylhexylamino Acids and Their Effect on Lead Decorporation. Chem. Res. Toxicol.. 2007,20:609-615.SCI
6. Ming Zhao, Zheng Li, Yihui Wu, Chao Wang, Ziding Zhang, Shiqi Peng*.Studies on LogP, Retention Time and QSAR of 2-Substitutedphenylnitronyl Nitroxides as Free Radical Scavenger. Eur. J. Med. Chem.. 2007,42:955-965.SCI
7. Jiawang Liu, Guofeng Wu, Guohui Cui, Wei-Xuan Wang, Ming Zhao, Chao Wang, Ziding Zhang, Shiqi Peng*.A new class of anti-thrombosis hexahydropyrazino[1’,2’:1,6]- pyrido[3,4-b]indole-1,4-dions: Design, synthesis, logK determination and QSAR analysis. Bioorg. Med. Chem.. 2007,15:5672-5693.SCI
8. Yu Xiong, Ming Zhao, Chao Wang, Hengwei Chang, Shiqi Peng*.Improved Antiosteoporosis Potency and Reduced Endometrial Membrane Hyperplasia During HRT with Estrogen-RGD Peptide Conjugates. J Med. Chem.. 2007,50:3340-3353.SCI
9. Wei Bi, Lanrong Bi, Jianhui Cai, Sanguang Liu, Shiqi Peng*.Nicholas O. Fischer, Jeffrey B.-H. Tok and Guohua Wang, Dual-acting agents that possess free radical scavenging and antithrombotic activities: Design, synthesis, and evaluation of phenolic tetrahydro-β-carboline RGD peptide conjugates. Bioorganic & Medicinal Chemistry Letters. 2006,16(2):4523-4527.SCI
10. Ming Zhao, Lanrong Bi, Wei Wang, Chao Wang, Michèle Baudy-Floc’h, Jingfang Ju, Shiqi Peng*.Synthesis and cytotoxic activities of β-carboline amino acid ester conjugates. Bioorg. & Med. Chem. 2006,14:6998-7010.SCI
11. Yihui Wu, Lanrong Bi, Wei Bi, Zeng Li, Ming Zhao, Chao Wang, Jingfang Ju, Shiqi Peng*.Synthesis, biological evaluation and structure–activity relationship. Bioorg. & Med. Chem. 2006,14:5711-5720.SCI
12. Keli Gu, Lanrong Bi, Ming Zhao, Chao Wang, Cheryl Dolan, Michael C. Kao, Jeffrey B.-H. Tok and Shiqi Peng*.Stereoselective synthesis and anti-inflammatory activities of 6- and 7-membered dioxacycloalkanes. Bioorg. & Med. Chem. 2006,14:1339-1347.SCI
13. Ming Zhao, Lanrong Bi, Wei Bi, Chao Wang, Zhe Yang, Jingfang Ju and Shiqi Peng*.Synthesis of new class dipeptide analogues with improved permeability and antithrombotic activity. Bioorg. & Med. Chem. 2006,14:4761-4774.SCI
14. Ming Zhao, Junling Liu, Chao Wang, Lili Wang, Hu Liu, Shiqi Peng*.Biological Activity of Nitronyl Nitroxide Containing Peptides. J Med. Chem. 2005,48:4285-4292.SCI
15. Lanrong Bi, Yue Zhang, Ming Zhao, Chao Wang, Priscilla Chan, Jeffrey B.-H. Tok, Shiqi Peng*.Novel Synthesis and Anti-inflammatory Activities of 2,5-disubstituted-dioxacycloalkanes. Bioorg. & Med. Chem.. 2005,13:5640-5646.SCI
16. Ming Zhao, Junling Liu, Chao Wang, Lili Wang, Hu Liu, Shiqi Peng*.Synthesis and Biological Activity of Nitronyl Nitroxide Containing Peptides. J Med. Chem.. 2005,48:4285-4292.SCI
17. Lanrong Bi, Yue Zhang, Ming Zhao, Chao Wang, Priscilla Chan, Jeffrey B.-H. Tok, Shiqi Peng*.Novel Synthesis and Anti-inflammatory Activities of 2,5-disubstituted- dioxacycloalkanes. Bioorg. & Med. Chem. . 2005,13:5640-5646.SCI
18. Caixia Huo, Chao Wang, Ming Zhao, Shiqi Peng*.Stereoselective synthesis and anti-Stereoselective synthesis of epi- merically pureN-(1-Deoxy-D- fructos-1-yl)-L-amino acids and their effect on lead decorporation. Chem. Res.Toxicol. 2004,17: 1112-1120.SCI
19. Wenfeng Ding, Chao Wang, Ming Zhao, Shiqi Peng*.The synthesis, distribution and anti-hepatic cancer activity of YSL. Bioorg. & Med. Chem. 2004,12:4989-4994.SCI
20. Chao Wang, Ming Zhao,Jian Yang, Xingwei Li, Shiqi Peng*.Synthesisi and evaluation of pentahydroxylhexyl-L-cysteine and its dimmer as chelating agents for cadmium or lead decorporation. Toxicology and Applied Pharmacology. 2004,200:229-236.SCI
21. Ming Zhao, Chao Wang, Yanfen Wu, Kexiang Zhou, and Shiqi Peng*.Synthesis and Thrombolytic Activity of Carboline-3-carboxylic Acid Modified Metabolites of ARPAK. Preparative Biochemistry & Biotechnology. 2004,34:55-74.SCI
22. Wang YY, Tang ZY, Dong M, Liu XY, Peng SQ*.Inhibition of platelet aggregation by polyaspartoyl L-arginine and its potential mechanism. Acta Pharmacol Sin. 2004,25:469-473.SCI
23. Chao Wang, Ming Zhao, Shiqi Peng*.The synthesis and immunosup- pressive activities of steroid- urotoxin linkers. Bioorg. & Med. Chem. 2004,12:4403-4421.SCI
主编或副主编的著作/译著
1. 《《药物化学原理》》,主编,北京大学医学出版社,2005
2. 《《预防药学》》,主编,北京大学医学出版社,2003
3. 《《药物的波谱解析》》,主编,北京大学医学出版社,2003
4. 《《新药的发现与发明》》,主编,山东省科技出版社,2001
5. 《多肽药物化学》,主编,科学出版社,1993
6. 《光谱立体化学》,主编,山西科学技术出版社,1993
重要奖项
1. 21世纪初药学研究型人才培养模式研究与实践 北京市教学成果壹等奖 2005
2. 治疗血栓和骨质疏松的关键技术 北京市科技进步贰等奖 2005
3. 新型口服重金属驱排立得益片 四川省科技进步叁等奖 2003
4. 重金属驱排先导结构的发现与优化 北京市科技进步叁等奖 2002
5. 大药学教学改革与实践 国家教学成果贰等奖 2001
6. 大药学教学改革与实践 北京市教学成果壹等奖 2000
职务：院长 招生院所：化学生物学与药学院
招生类型：科学学位(博) 科学学位(硕)
招生专业：神经生物学(博) 药物化学(硕)
研究方向名称：氨基酸的杂环先导结构的研究
电子信箱：
社会任职
个人简历
重要学术论文
1. Ming Zhao, Xin Jia, Chao Wang, Qin Li, Kexiang Zhou, Lili Wang, Hu Liu and Shiqi Peng*.PAK: An Essential Motif for Forming β-Turn Structures and Exhibiting Thrombolytic Effect for P6A and Its Analogs. Biochem. Cell Biol.. 2007,85:730-740.SCI
2. Jianghui Wu, Guohui Cui, Ming Zhao, Chunying Cui, & Shiqi Peng*.Novel N-(3-Carboxyl-9-benzylcarboline-1-yl)ethylamino Acids: Synthesis, Anti-proliferation Activities and Two Step Course of Intercalation Toward Calf Thymus DNA. Molecular BioSystems. 2007,3:855-861.SCI
3. Ming Zhao, Zheng Li, Li Peng, Yu-Rong Tang, Chao Wang, Ziding Zhang, Shiqi Peng*.Novel 1-Oxyl-2-substitutedphenyl-4,4,5,5-tetramethylimidazolines: Synthesis, Selectively Analgesic Action and QSAR analysis. Bioorg. Med. Chem.. 2007,15:2815-2826.SCI
4. Guofeng Wu, Lanrong Bi, Ming Zhao, Chao Wang, Michèle Baudy-Floc’h , Jingfang Ju, Shiqi Peng*.Toward Breast Cancer Resistance Protein (BCRP) Inhibitors: Design, Synthesis of A Series of New Simplified Fumitremorgin C Analogues. Tetrahedron. 2007,63:5510-5528.SCI
5. Yuji Wang, Lanrong Bi, Baoguang Hou, Yu Chen, Ming Zhao, Chao Wang, Wei Wang, Jingfang Ju,| Shiqi Peng*. Design and Synthesis of Pentahydroxylhexylamino Acids and Their Effect on Lead Decorporation. Chem. Res. Toxicol.. 2007,20:609-615.SCI
6. Ming Zhao, Zheng Li, Yihui Wu, Chao Wang, Ziding Zhang, Shiqi Peng*.Studies on LogP, Retention Time and QSAR of 2-Substitutedphenylnitronyl Nitroxides as Free Radical Scavenger. Eur. J. Med. Chem.. 2007,42:955-965.SCI
7. Jiawang Liu, Guofeng Wu, Guohui Cui, Wei-Xuan Wang, Ming Zhao, Chao Wang, Ziding Zhang, Shiqi Peng*.A new class of anti-thrombosis hexahydropyrazino[1’,2’:1,6]- pyrido[3,4-b]indole-1,4-dions: Design, synthesis, logK determination and QSAR analysis. Bioorg. Med. Chem.. 2007,15:5672-5693.SCI
8. Yu Xiong, Ming Zhao, Chao Wang, Hengwei Chang, Shiqi Peng*.Improved Antiosteoporosis Potency and Reduced Endometrial Membrane Hyperplasia During HRT with Estrogen-RGD Peptide Conjugates. J Med. Chem.. 2007,50:3340-3353.SCI
9. Wei Bi, Lanrong Bi, Jianhui Cai, Sanguang Liu, Shiqi Peng*.Nicholas O. Fischer, Jeffrey B.-H. Tok and Guohua Wang, Dual-acting agents that possess free radical scavenging and antithrombotic activities: Design, synthesis, and evaluation of phenolic tetrahydro-β-carboline RGD peptide conjugates. Bioorganic & Medicinal Chemistry Letters. 2006,16(2):4523-4527.SCI
10. Ming Zhao, Lanrong Bi, Wei Wang, Chao Wang, Michèle Baudy-Floc’h, Jingfang Ju, Shiqi Peng*.Synthesis and cytotoxic activities of β-carboline amino acid ester conjugates. Bioorg. & Med. Chem. 2006,14:6998-7010.SCI
11. Yihui Wu, Lanrong Bi, Wei Bi, Zeng Li, Ming Zhao, Chao Wang, Jingfang Ju, Shiqi Peng*.Synthesis, biological evaluation and structure–activity relationship. Bioorg. & Med. Chem. 2006,14:5711-5720.SCI
12. Keli Gu, Lanrong Bi, Ming Zhao, Chao Wang, Cheryl Dolan, Michael C. Kao, Jeffrey B.-H. Tok and Shiqi Peng*.Stereoselective synthesis and anti-inflammatory activities of 6- and 7-membered dioxacycloalkanes. Bioorg. & Med. Chem. 2006,14:1339-1347.SCI
13. Ming Zhao, Lanrong Bi, Wei Bi, Chao Wang, Zhe Yang, Jingfang Ju and Shiqi Peng*.Synthesis of new class dipeptide analogues with improved permeability and antithrombotic activity. Bioorg. & Med. Chem. 2006,14:4761-4774.SCI
14. Ming Zhao, Junling Liu, Chao Wang, Lili Wang, Hu Liu, Shiqi Peng*.Biological Activity of Nitronyl Nitroxide Containing Peptides. J Med. Chem. 2005,48:4285-4292.SCI
15. Lanrong Bi, Yue Zhang, Ming Zhao, Chao Wang, Priscilla Chan, Jeffrey B.-H. Tok, Shiqi Peng*.Novel Synthesis and Anti-inflammatory Activities of 2,5-disubstituted-dioxacycloalkanes. Bioorg. & Med. Chem.. 2005,13:5640-5646.SCI
16. Ming Zhao, Junling Liu, Chao Wang, Lili Wang, Hu Liu, Shiqi Peng*.Synthesis and Biological Activity of Nitronyl Nitroxide Containing Peptides. J Med. Chem.. 2005,48:4285-4292.SCI
17. Lanrong Bi, Yue Zhang, Ming Zhao, Chao Wang, Priscilla Chan, Jeffrey B.-H. Tok, Shiqi Peng*.Novel Synthesis and Anti-inflammatory Activities of 2,5-disubstituted- dioxacycloalkanes. Bioorg. & Med. Chem. . 2005,13:5640-5646.SCI
18. Caixia Huo, Chao Wang, Ming Zhao, Shiqi Peng*.Stereoselective synthesis and anti-Stereoselective synthesis of epi- merically pureN-(1-Deoxy-D- fructos-1-yl)-L-amino acids and their effect on lead decorporation. Chem. Res.Toxicol. 2004,17: 1112-1120.SCI
19. Wenfeng Ding, Chao Wang, Ming Zhao, Shiqi Peng*.The synthesis, distribution and anti-hepatic cancer activity of YSL. Bioorg. & Med. Chem. 2004,12:4989-4994.SCI
20. Chao Wang, Ming Zhao,Jian Yang, Xingwei Li, Shiqi Peng*.Synthesisi and evaluation of pentahydroxylhexyl-L-cysteine and its dimmer as chelating agents for cadmium or lead decorporation. Toxicology and Applied Pharmacology. 2004,200:229-236.SCI
21. Ming Zhao, Chao Wang, Yanfen Wu, Kexiang Zhou, and Shiqi Peng*.Synthesis and Thrombolytic Activity of Carboline-3-carboxylic Acid Modified Metabolites of ARPAK. Preparative Biochemistry & Biotechnology. 2004,34:55-74.SCI
22. Wang YY, Tang ZY, Dong M, Liu XY, Peng SQ*.Inhibition of platelet aggregation by polyaspartoyl L-arginine and its potential mechanism. Acta Pharmacol Sin. 2004,25:469-473.SCI
23. Chao Wang, Ming Zhao, Shiqi Peng*.The synthesis and immunosup- pressive activities of steroid- urotoxin linkers. Bioorg. & Med. Chem. 2004,12:4403-4421.SCI
主编或副主编的著作/译著
1. 《《药物化学原理》》,主编,北京大学医学出版社,2005
2. 《《预防药学》》,主编,北京大学医学出版社,2003
3. 《《药物的波谱解析》》,主编,北京大学医学出版社,2003
4. 《《新药的发现与发明》》,主编,山东省科技出版社,2001
5. 《多肽药物化学》,主编,科学出版社,1993
6. 《光谱立体化学》,主编,山西科学技术出版社,1993
重要奖项
1. 21世纪初药学研究型人才培养模式研究与实践 北京市教学成果壹等奖 2005
2. 治疗血栓和骨质疏松的关键技术 北京市科技进步贰等奖 2005
3. 新型口服重金属驱排立得益片 四川省科技进步叁等奖 2003
4. 重金属驱排先导结构的发现与优化 北京市科技进步叁等奖 2002
5. 大药学教学改革与实践 国家教学成果贰等奖 2001
6. 大药学教学改革与实践 北京市教学成果壹等奖 2000
