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刘刚老师介绍
刘刚，1963年8月出生，中华人民共和国教育部2004年度“长江学者”奖励计划特聘教授，博士，博士生导师，专业药物化学， 研究方向组合化学与化学生物学。
电话：010-63167165(O)
010-63165246(L)
传真：010-63167165
Email：gliu@imm.ac.cn
学历：
博士：1994年7月获得，北京医科大学药学院
本科和硕士：1988年5月获得，哈尔滨师范大学化学系
中国延安干部学院第三期高级专家理论研究班，2008年9月
专业背景：
1997年10月-2000年8月：研究助理，高级研究助理， University of California, Davis。研究方向：寻找新药先导化合物的组合化学
1997年1月-1997年9月：博士后，The Scripps Research Institute。研究方向：合成构象限定性HIV多肽疫苗的研究
1994年10月-1996年12月：博士后，军事医学科学院毒物药物研究所。研究方向：寻找新药先导化合物的组合化学
访问经历：
1995年3月-1995年5月：Chiron Mimotopes Pty Ltd., 澳大利亚
工作经历：
2000年9月-至今： “协和学者”特聘教授，中国医学科学院、中国协和医科大学药物研究所
课题组研究兴趣：
课题组主要开展与发现和优化药物先导化合物相关的组合化学与化学生物学研究工作，重点解决在寻找和优化药物先导化合物的过程中一些与组合化学与化学生物学相关的方法、技术、理论等前沿性科学问题。包括组合合成“骨架导向”的小分子杂环化合物化学库、多肽及多肽模拟物化学库、以天然产物为骨架分子的化学库、“协同作用”化学库、抗肿瘤及抗感染的协同治疗作用等，以及与此化学库相关的快速定性和定量分析、固载化分子定性与定量、固载化分子间的相互作用等研究内容。课题组的研究目标是寻找抗肿瘤、抗病毒药物以及与肿瘤和病毒感染性疾病相关的免疫治疗药物和疫苗。其中以本课题组牵头并与国内其他课题组共同联合申请有关SARS-CoV多肽疫苗的研究获得了美国国家健康研究所(NIH)的资助（2005,4-2010,3）。
近年来发表的主要研究性论文：
1. Dongmei Wang, Mingna Sun, Gang Liu*, Substituent Diversity-Directed Synthesis of Indole Derivatives, Journal of Combinatorial Chemistry, 2009, accepted.
2. Hong-yan PANG, Gang LIU, Geng-tao LIU*, Compound FLZ inhibits lipopolysaccharide-induced inflammatory effects via down-regulation of the TAK-IKK and TAK-JNK/p38MAPK pathways in RAW264.7 macrophages, Acta Pharmacol Sin, 2009, 30 (2): 209–218.
3. Fa Zhang, Wei Zhang, Yan Zhang, Dennis P. Curran, and Gang Liu*, Synthesis and Applications of Light-Fluorous Glycosyl Donor, The Journal of Organic Chemistry, 2009, 74 (6), 2594-2597.
4. Bian C, Zhang X, Cai X, Zhang L, Chen Z, Zha Y, Xu Y, Xu K, Lu W, Yan L, Yuan J, Feng J, Hao P, Wang Q, Zhao G, Liu G, Zhu X, Shen H, Zheng B, Shen B, Sun B, Conserved amino acids W423 and N424 in receptor-binding domain of SARS-CoV are potential targets for therapeutic monoclonal antibody, Virology, 2009, 383(1):39-46.
5. Lei Liu, Leilei Zhang, Gang Liu, Jiaxi Xu*, Synthesis of spiro-fused polycyclic β-lactam derivatives, ARKIVOC, 2008 (xvi), 318-326.
6. Tao MA, Li LIU, Hai XUE, Li LI, Chunyan HAN, Lin WANG, Zhiwei CHEN, Gang LIU*, The Chemical Library and Structure-Activity Relationship of Calanolide-A Analogues against HIV-1, Journal of Medicinal Chemistry, 2008, 51, 1432–1446.
7. Yu-Yan Chen, Wen-Yi He, Yan Wu, Chang-Qun Niu, and Gang Liu*, Dynamic Selection of Novel Vancomycin N-Terminal Derivatives by Resin-bound Reversed D-Ala-D-Ala, Journal of Combinatorial Chemistry, 2008, 10, 914-922.
8. Lin Wang, Hong-Shan Chen, Pei-Zhen Tao, Yan Li, Yun Bai, Jin-Ping Hu, Ling Biao, Tao Ma, Zhen-Tang Xing, Zong Gen Peng, Chun-Mei Zhou, Qi Gao, Xing-Quan Zhang, Gang Liu*, and Xiao-Tian Liang, Improved synthesis and the pharmaceutical evaluation of racemic 11-demethyl Calanolide A, 药学学报 (Acta Pharmaceutica Sinica), 2008, 43(7): 707-718.
9. 彭宗根，陈鸿珊*，王琳，刘刚，HIV逆转录酶抑制剂消旋11-去甲胡桐素A的抗HIV-1活性研究 (Anti-HIV activities of HIV-1 reverse transcriptase inhibitor racemic 11-demethyl-calanolide A)，药学学报 (Acta Pharmaceutica Sinica), 2008, 43(5): 456-460。
10. Xuqin Li, Junli Yu, Song Xu, Nan Wang, Hongzhen Yang, Zheng Yan, Guifang Cheng, Gang Liu*, Chemical Conjugation of Muramyl Dipeptide and Paclitaxel to Explore the Combination of Immunotherapy and Chemotherapy for Cancer, Glycoconjugate Journal, 2008, 25: 415–425.
11. Hongyu Zhou, Qingxin Mu, Ningning Gao, Aifeng Liu, Yuehan Xing, Sulian Gao, Qiu Zhang, Guangbo Qu, Yuyan Chen, Gang Liu, Bin Zhang, Bing Yan*, A Nano-Combinatorial Library Strategy for the Discovery of Nanotubes with Reduced Protein-Binding, Cytotoxicity, and Immune Response, Nano Letters, 2008, 8(3): 859-865.
12. Tao MA, Qi GAO, Zhiwei Chen, Lin WANG, Gang LIU*, Chemical Resolutions of (±)-Calanolide A, (±)-Cordatolide A and Their 11-Demethyl Derivatives, Bioorg. & Med. Chem. Letts. 2008， 18, 1079–1083.
13. Boyuan Wang, Wei Zhang, Leilei Zhang, Da-Ming Du, Gang Liu, and Jiaxi Xu*, Versatile Synthesis of Free and N-Benzyloxycarbonyl-Protected 2,2-Disubstituted Taurines, Eur. J. Org. Chem. 2008, 350–355.
14. Hai-Yan Zhao, Gang Liu* Solution-Phase Parallel Synthesis of Diverse 1,5-Benzodiazepin-2-ones, Journal of Combinatorial Chemistry, 2007, 9, 1164 - 1176.
15. Li Li, Zhanguo Wang, Yuyan Chen, Yunyun Yuan, Guanxin Wang, Gang Liu*, Design and Synthesis of Novel Tricyclic Compounds Based On 4H-Benzo[1,4]thiazin-3-one and 1,1-Dioxo-1,4-dihydro-2H-1l6-benzo[1,4]thiazin-3-one, Journal of Combinatorial Chemistry, 2007, 9, 959 - 972.
16. Hai-Yan Zhao, Gang Liu*, Solution-Phase Synthesis of 2, 3-Dihydro-1,5-benzothiazepin-4 (5H)-ones, Journal of Combinatorial Chemistry, 2007, 9, 756-772.
17. Zhanguo Wang, Yunyun Yuan, Yuyan Chen, Ganghcun Sun, Xianghong Wu, Shenmei Zhang, Chunyan Han, Guanxing Wang, Li Li, and Gang Liu*, Design and Parallel Solution-phase Synthesis of Diverse Scaffold Compounds Based On 3,4-Dihydrogen-3-oxo-1,4-benzothiazine, Journal of Combinatorial Chemistry, 2007, 9, 652-660.
18. Yunyun Yuan, Gang Liu,* Li Li, Zhanguo Wang, and Lin Wang, Synthesis of Benzo[1,4]oxazin-3-one-based Diverse Compounds Using 1, 5-Difluoro-2, 4-dinitrobenzene, Journal of Combinatorial Chemistry, 2007, 9, 158-170.
19. Tian-Ming Yang, Gang Liu*, Solution-Phase Parallel Synthesis of 3-Substituted Indolin-2-ones, Journal of Combinatorial Chemistry, 2007, 9, 86-95.
20. Gang Liu,* Li Li, Binbin Kou, Suode Zhang, Liang Zhang, Yunyun Yuan, Tao Ma, Yan Shang, and Yuancheng Li, Benzofused Tricycles Based On 2-Quinoxalinol, Journal of Combinatorial Chemistry, 2007, 9, 70-78.
21. Bin-Bin KOU, Fa ZHANG, Tian-Ming YANG, Gang LIU*, Simultaneous Solid-Phase Synthesis of Quinoxalinone and Benzimidazole Scaffold Libraries, Journal of Combinatorial Chemistry, 2006, 8, 841-847.
22. A. Salomé Veiga, Yunyun Yuan, Xuqin Li, Nuno C. Santos, Gang Liu*, and Miguel A. R. B. Castanho*, Why aren’t HIV-1 fusion inhibitors effective against SARS-CoV?, Biochimica Biophysica Acta (BBA), 2006, 1760, 55-61.
23. Hongbo Hu, Li Li , Richard Y. Kao, Binbin Kou, Zhanguo Wang, Liang Zhang, Huiyuan Zhang, Zhiyong Hao, Wayne H. Tsui, Anping Ni, Lianxian Cui, Baoxing Fan, Feng Guo, Shuan Rao, Chengyu Jiang, Qian Li, Manji Sun, Wei He*, Gang Liu*, Screening and Identification of Linear B-cell Epitopes and Entry Blocking Peptide of Severe Acute Respiratory Syndrome (SARS) Associated Coronavirus Using Synthetic Overlapping Peptide Library, Journal of Combinatorial Chemistry, 2005, 7, 648-656.
24. Jiang Zhang, Liang Zhang, Suode Zhang, Gang Liu*，Solution-Phase Parallel Synthesis of a Novel 1,2,7-trialkyl-1H-imidazo[4,5-g]quinoxalin-6-ol Library Scaffold, Journal of Combinatorial Chemistry, 2005, 7, 657-664.
25. Hong-Zhen Yang, Song Xu, Xue-Yan Liao, Suo-De Zhang, Zheng-Lun Liang, Bai-He Liu, Jin-Ye Bai, Chao Jiang, Jian Ding, Gui-Fang Cheng*, Gang Liu*, A novel immunostimulator, N2-[a-O-benzyl-N-(acetylmuramyl)-L-alanyl-D-isoglutaminyl]-N6-trans-(m-nitrocinnamoyl)-L-lysine (MDP-C), and its adjuvancy on the hepatitis B surface antigen, Journal of Medicinal Chemistry, 2005, 48, 5112-5122.
26. Nian-Huan Yao, Gang Liu,* Wen-Yi He, Changqun Niu, James R. Carlson, Kit S. Lam, Solid-phase synthesis and antibacterial evaluations of N-demethylvancomycin derivatives, Bioorg. & Med. Chem. Lett., 2005, 15(9): 2325-2329.
27. Nian-Huan Yao, Wen-Yi He, Kit S. Lam, and Gang Liu*, Conformational Studies of Resin-Bound Vancomycin and The Complex of Vancomycin and Ac2-L-Lys-D-Ala-D-Ala, Journal of Combinatorial Chemistry, 2005, 7, 123-129.
28. Li Li, Gang LIU*, Zhanguo Wang, Yunyun Yuan, Chunxu Zhang, Xianghong Wu, Jing Zhang, Multi-step parallel synthesis of substituted 5-aminobenzimidazoles in solution-phase, Journal of Combinatorial Chemistry, 2004, 6, 811-821.
29. Nian-Huan YAO, Wen-Yi HE, Kit S. LAM, Gang LIU*, Solid-Phase Synthesis of O-glycosylated Na-Fmoc Amino Acids and Analysis By The High Resolution Magic Angle Spinning NMR (HR/MAS NMR), Journal of Combinatorial Chemistry, 2004, 6, 214-219.
30. Xin-Mei Zhang, Gang Liu, Man-Ji Sun*, Anti-epitope antibody, a novel site-directed antibody against human acetylcholinesterase, Acta Pharmacol. Sin. 2004, 25(4): 431-435.
31. Liang ZHANG, Gang LIU*, Suo-De ZHANG, Xiang-Hong WU, Hong-Zhen YANG, Li LI, Gang-Chun SUN, Bin-Bin KOU, Song XU, Ya-Fei JI, Gui-Fang CHENG, Parallel approach for solution-phase synthesis of 2-quinoxalinol analogues and their inhibition of LPS-induced TNF-a release on mouse macrophage in vitro, Journal of Combinatorial Chemistry, 2004, 6, 431-436.
32. Xiang-Hong Wu, Gang Liu*, Jing Zhang, Zhan-Guo Wang, Song Xu, Suo-De Zhang, Liang Zhang, Lin Wang, Solution-phase reductive cyclization of 2-quinoxalinol analogs: systematic study of parallel synthesis, Molecular Diversity, 2004, 8 (2): 165-174.
33. Zhang Xing-mei, Li Qian, Wu Jun-hua, Shao Ning-sheng, Liu Gang, Sun Man-ji*, Specific oligobodies against human brain acetylcholinesterase", Brain Research, 2003, 989; 2: 147-151.
34. 贺文义，姚念环，LAM , Kit S.，刘刚*, 高分辨魔角核磁共振技术（HR/MAS）在固相合成中的应用，波谱学杂志，2003, 20(2): 201-208。
35. LIU XM, ZHANG DJ, CAO GJ, YANG G, DING HM, LIU G, FAN M, SHEN BF and SHAO NS*, RNA Aptamers Specific for Bovine Thrombin, Journal of Molecular Recognition, 2003, 16:23-27.
36. 刘刚*，范业梅，赵占工，Kit S LAM， “一珠一化合物”组合化学方法筛选抗万古霉素耐药菌活性化合物，中国药物化学杂志, 2002，12（6）：311-318。
37. Nagy SR, Liu G, Lam KS, Denison MS*, Identification of Novel Ah Receptor Agonists Using a High-Throughput Green Fluorescent Protein-Based Recombinant Cell Bioassay, Biochemistry, 2002, 41(3): 861-868.
38. Suo-De ZHANG, Gang LIU*, Shu-Quan XIA, Ping WU, Liang ZHANG, “Meshed-Bag Gathered-Bunch” method for solid-phase synthesis of small molecular diverse compounds, Journal of Combinatorial Chemistry, 2002, 4, 131-137.
39. Suo-De ZHANG, Gang LIU*, Su-Quan XIA, Ping WU, Design and synthesis of muramyl dipeptide cyclic analogue, Chinese Chemical Letters, 2002, 13(1), 17-18.
40. Suo-De ZHANG, Gang LIU*, Su-Quan XIA, Design and solid-phase synthesis of multiple muramyl dipeptide(MMD), Chinese Chemical Letters, 2001, 12(10): 887-888.
41. Xin-Mei ZHANG, Gang LIU, Man-Ji SUN*, Cross-immunoreactivity of synthetic antigenic decapeptides of human brain acetylcholinesterase with anti-Torpedo acetylcholinesterase polyclonal antibodies, Brain Research, 2001, 895(1-2): 277-282.
42. Xin-Mei ZHANG, Gang LIU, Man-Ji SUN*, Epitopes of human brain Acetylcholinesterase, Brain Research, 2000, 868: 157-164.
43. Gang LIU, Ye-Mei FAN, James R. CALSON, and Kit S. LAM*, Solution-phase synthesis of 1,5-dialkylamino-2,4-dinitrobenzene library and the identification of novel antibacterial compounds from this library, Journal of Combinatorial Chemistry, 2000, 2(5), 467-474.
44. Gang LIU*, Shuo-De ZHANG, Shu-Quan XIA, and Zhen-Kai DING, Solid-phase synthesis of muramyl dipeptide derivatives using Multipin method, Bioorg. & Med. Chem. Lett., 2000, 10, 1361-1363.
45. Gang LIU*, Shao-Feng MU, Liu-Hong YUN, Zhen-Kai DING, Man-Ji SUN, Systematic studies of the substituted active C-terminus of hirudin, Journal of Peptide Research, 1999, 54(6), 480-490.
参与编写和著书、导读：
1. Lin Wang , Tao Ma, and Gang Liu, Chapter 8: Recent Process in Calophyllum Coumarins as Potent Anti-HIV Agents, Medicinal Chemistry of Bioactive Products, edited by Profs. Xiao-tian Laing and Wei-shuo Fang, Wiley press, 2006, chapter 8, pg 325-351.
2. Gang LIU and Kit S. LAM, “One-bead one-compound combinatorial library method”, Combinatorial Chemistry, A Practical Approach, Edited by Hicham Fenniri, OXFORD University Press, 2000, Chapter 2, pp 33-50.
3. 刘刚，彦宇，导读“Comprehensive Medicinal Chemistry II”(Editors-in-Chief: Dr. John B Taylor and Professor David J Triggle)第三册：Drug Discovery Technologies. Edited by Professor Hugo Kubinyi.
4. 刘刚，萧晓毅等著，《寻找新药研究中的组合化学》，科学出版社，2003，6月。
5. 刘刚，组合化学与群集筛选，《中国药物研究与开发》，孙蔓霁主编，科学出版社，1996。
专利：
1. 消旋和光活胡桐素A及其类似物的制备方法，申请号：03123628.6。
2. 平行过滤箱，专利号：ZL03265620.3。
3. 消旋去甲胡桐素A制备抗爱滋病毒类药物中的应用及其与其他抗HIV-1抑制剂的联用，申请号：03142512.7。
4. 一种肽文库、其合成方法及从该文库中筛选的活性片段，申请号：200310101892.6。
5. Na-（1-a-苄基-N-乙酰基-胞壁酰-L-丙酰胺-D-异谷氨酰胺酰）-Ne（3-硝基-反式苯乙烯基）-L-赖氨酰胺、制法和其药物组合物与用途，申请号：200310101618.9。
6. 具有广泛交叉免疫反应性的冠状病毒（SARS-CoV）B-细胞抗原决定簇， 批准号：ZL200410073853.4。
7. 冠状病毒特异性T-细胞抗原决定簇，批准号：ZL200410074566.5。
8. 抗癌药物紫杉醇和免疫增强剂胞壁酰二肽(胞壁酰丙胺酰异谷胺酰胺)共轭物的制备及其活性，申请号：200410049667.7。
9. 四环双吡喃香豆素化合物及其抗HIV和抗结核菌用途, 申请号：PCT/CN7007/003139。
10. 胞壁酰二肽的类似物, 申请号：200610098615.8。
综述：
1、 韩春艳，李燕，刘刚，“似药性”：预测与实践，化学进展(Progress in Chemistry)，2008, 20(9),1335-1344.
2、 陈玉岩，刘刚，动态组合化学研究最新进展，化学进展(Progress in Chemistry)，2007，19（12）, 11903-1908。
3、 赵海燕，刘刚，苯并硫氮杂卓类化合物的研究进展，中国药物化学杂志，2007, 17（2）， 122-128。
4、 陈玉岩，刘刚，万古霉素衍生物的合成与活性研究进展(Recent Advances of Synthesis and Activity of Vancomycin Derivatives)，药学学报(Acta Pharmaceutica Sinica)，2007, 42(5), 463-469。
5、 杨天明，刘刚，吲哚及其类似物的药理活性和固相合成研究进展（Recent Progress in Pharmacological Activities and Solid-Phase Synthesis of Indoles and Analogues），药学学报 (Acta Pharmaceutica Sinica)，2006, 41(8), 694-701。
6、 张亮，刘刚，固载化试剂和催化剂及其在液相组合合成中的应用(Solid-Supported Reagents，Catalysts and Their Use in Solution-Phase Combinatorial Synthesis)，有机化学(Chinese Journal of Organic Chemistry)，2006，26（7），885-898。
7、 李旭琴，徐嵩，刘刚，天然产物衍生物化学库的组合合成研究进展(Recent developments in combinatorial synthesis of libraries of natural product analogues)，化学进展(Progress in Chemistry)，2006，18（9）, 1130-1142。
8、 张法，刘刚, 糖肽的固相合成(Solid-phase Synthesis of Glycopeptides), 化学进展(Progress in Chemistry)，2006，18（5），579-600。
9、 姚念环，贺文义，Kit S. LAM，刘刚, 核磁共振技术（NMR）在组合化学中的应用(Applications of Nuclear Magnetic Resonance Spectroscopy (NMR) to Combinational Chemistry)，化学进展(Progress in Chemistry)，2004, 16(5): 696-707。
电话：010-63167165(O)
010-63165246(L)
传真：010-63167165
Email：gliu@imm.ac.cn
学历：
博士：1994年7月获得，北京医科大学药学院
本科和硕士：1988年5月获得，哈尔滨师范大学化学系
中国延安干部学院第三期高级专家理论研究班，2008年9月
专业背景：
1997年10月-2000年8月：研究助理，高级研究助理， University of California, Davis。研究方向：寻找新药先导化合物的组合化学
1997年1月-1997年9月：博士后，The Scripps Research Institute。研究方向：合成构象限定性HIV多肽疫苗的研究
1994年10月-1996年12月：博士后，军事医学科学院毒物药物研究所。研究方向：寻找新药先导化合物的组合化学
访问经历：
1995年3月-1995年5月：Chiron Mimotopes Pty Ltd., 澳大利亚
工作经历：
2000年9月-至今： “协和学者”特聘教授，中国医学科学院、中国协和医科大学药物研究所
课题组研究兴趣：
课题组主要开展与发现和优化药物先导化合物相关的组合化学与化学生物学研究工作，重点解决在寻找和优化药物先导化合物的过程中一些与组合化学与化学生物学相关的方法、技术、理论等前沿性科学问题。包括组合合成“骨架导向”的小分子杂环化合物化学库、多肽及多肽模拟物化学库、以天然产物为骨架分子的化学库、“协同作用”化学库、抗肿瘤及抗感染的协同治疗作用等，以及与此化学库相关的快速定性和定量分析、固载化分子定性与定量、固载化分子间的相互作用等研究内容。课题组的研究目标是寻找抗肿瘤、抗病毒药物以及与肿瘤和病毒感染性疾病相关的免疫治疗药物和疫苗。其中以本课题组牵头并与国内其他课题组共同联合申请有关SARS-CoV多肽疫苗的研究获得了美国国家健康研究所(NIH)的资助（2005,4-2010,3）。
近年来发表的主要研究性论文：
1. Dongmei Wang, Mingna Sun, Gang Liu*, Substituent Diversity-Directed Synthesis of Indole Derivatives, Journal of Combinatorial Chemistry, 2009, accepted.
2. Hong-yan PANG, Gang LIU, Geng-tao LIU*, Compound FLZ inhibits lipopolysaccharide-induced inflammatory effects via down-regulation of the TAK-IKK and TAK-JNK/p38MAPK pathways in RAW264.7 macrophages, Acta Pharmacol Sin, 2009, 30 (2): 209–218.
3. Fa Zhang, Wei Zhang, Yan Zhang, Dennis P. Curran, and Gang Liu*, Synthesis and Applications of Light-Fluorous Glycosyl Donor, The Journal of Organic Chemistry, 2009, 74 (6), 2594-2597.
4. Bian C, Zhang X, Cai X, Zhang L, Chen Z, Zha Y, Xu Y, Xu K, Lu W, Yan L, Yuan J, Feng J, Hao P, Wang Q, Zhao G, Liu G, Zhu X, Shen H, Zheng B, Shen B, Sun B, Conserved amino acids W423 and N424 in receptor-binding domain of SARS-CoV are potential targets for therapeutic monoclonal antibody, Virology, 2009, 383(1):39-46.
5. Lei Liu, Leilei Zhang, Gang Liu, Jiaxi Xu*, Synthesis of spiro-fused polycyclic β-lactam derivatives, ARKIVOC, 2008 (xvi), 318-326.
6. Tao MA, Li LIU, Hai XUE, Li LI, Chunyan HAN, Lin WANG, Zhiwei CHEN, Gang LIU*, The Chemical Library and Structure-Activity Relationship of Calanolide-A Analogues against HIV-1, Journal of Medicinal Chemistry, 2008, 51, 1432–1446.
7. Yu-Yan Chen, Wen-Yi He, Yan Wu, Chang-Qun Niu, and Gang Liu*, Dynamic Selection of Novel Vancomycin N-Terminal Derivatives by Resin-bound Reversed D-Ala-D-Ala, Journal of Combinatorial Chemistry, 2008, 10, 914-922.
8. Lin Wang, Hong-Shan Chen, Pei-Zhen Tao, Yan Li, Yun Bai, Jin-Ping Hu, Ling Biao, Tao Ma, Zhen-Tang Xing, Zong Gen Peng, Chun-Mei Zhou, Qi Gao, Xing-Quan Zhang, Gang Liu*, and Xiao-Tian Liang, Improved synthesis and the pharmaceutical evaluation of racemic 11-demethyl Calanolide A, 药学学报 (Acta Pharmaceutica Sinica), 2008, 43(7): 707-718.
9. 彭宗根，陈鸿珊*，王琳，刘刚，HIV逆转录酶抑制剂消旋11-去甲胡桐素A的抗HIV-1活性研究 (Anti-HIV activities of HIV-1 reverse transcriptase inhibitor racemic 11-demethyl-calanolide A)，药学学报 (Acta Pharmaceutica Sinica), 2008, 43(5): 456-460。
10. Xuqin Li, Junli Yu, Song Xu, Nan Wang, Hongzhen Yang, Zheng Yan, Guifang Cheng, Gang Liu*, Chemical Conjugation of Muramyl Dipeptide and Paclitaxel to Explore the Combination of Immunotherapy and Chemotherapy for Cancer, Glycoconjugate Journal, 2008, 25: 415–425.
11. Hongyu Zhou, Qingxin Mu, Ningning Gao, Aifeng Liu, Yuehan Xing, Sulian Gao, Qiu Zhang, Guangbo Qu, Yuyan Chen, Gang Liu, Bin Zhang, Bing Yan*, A Nano-Combinatorial Library Strategy for the Discovery of Nanotubes with Reduced Protein-Binding, Cytotoxicity, and Immune Response, Nano Letters, 2008, 8(3): 859-865.
12. Tao MA, Qi GAO, Zhiwei Chen, Lin WANG, Gang LIU*, Chemical Resolutions of (±)-Calanolide A, (±)-Cordatolide A and Their 11-Demethyl Derivatives, Bioorg. & Med. Chem. Letts. 2008， 18, 1079–1083.
13. Boyuan Wang, Wei Zhang, Leilei Zhang, Da-Ming Du, Gang Liu, and Jiaxi Xu*, Versatile Synthesis of Free and N-Benzyloxycarbonyl-Protected 2,2-Disubstituted Taurines, Eur. J. Org. Chem. 2008, 350–355.
14. Hai-Yan Zhao, Gang Liu* Solution-Phase Parallel Synthesis of Diverse 1,5-Benzodiazepin-2-ones, Journal of Combinatorial Chemistry, 2007, 9, 1164 - 1176.
15. Li Li, Zhanguo Wang, Yuyan Chen, Yunyun Yuan, Guanxin Wang, Gang Liu*, Design and Synthesis of Novel Tricyclic Compounds Based On 4H-Benzo[1,4]thiazin-3-one and 1,1-Dioxo-1,4-dihydro-2H-1l6-benzo[1,4]thiazin-3-one, Journal of Combinatorial Chemistry, 2007, 9, 959 - 972.
16. Hai-Yan Zhao, Gang Liu*, Solution-Phase Synthesis of 2, 3-Dihydro-1,5-benzothiazepin-4 (5H)-ones, Journal of Combinatorial Chemistry, 2007, 9, 756-772.
17. Zhanguo Wang, Yunyun Yuan, Yuyan Chen, Ganghcun Sun, Xianghong Wu, Shenmei Zhang, Chunyan Han, Guanxing Wang, Li Li, and Gang Liu*, Design and Parallel Solution-phase Synthesis of Diverse Scaffold Compounds Based On 3,4-Dihydrogen-3-oxo-1,4-benzothiazine, Journal of Combinatorial Chemistry, 2007, 9, 652-660.
18. Yunyun Yuan, Gang Liu,* Li Li, Zhanguo Wang, and Lin Wang, Synthesis of Benzo[1,4]oxazin-3-one-based Diverse Compounds Using 1, 5-Difluoro-2, 4-dinitrobenzene, Journal of Combinatorial Chemistry, 2007, 9, 158-170.
19. Tian-Ming Yang, Gang Liu*, Solution-Phase Parallel Synthesis of 3-Substituted Indolin-2-ones, Journal of Combinatorial Chemistry, 2007, 9, 86-95.
20. Gang Liu,* Li Li, Binbin Kou, Suode Zhang, Liang Zhang, Yunyun Yuan, Tao Ma, Yan Shang, and Yuancheng Li, Benzofused Tricycles Based On 2-Quinoxalinol, Journal of Combinatorial Chemistry, 2007, 9, 70-78.
21. Bin-Bin KOU, Fa ZHANG, Tian-Ming YANG, Gang LIU*, Simultaneous Solid-Phase Synthesis of Quinoxalinone and Benzimidazole Scaffold Libraries, Journal of Combinatorial Chemistry, 2006, 8, 841-847.
22. A. Salomé Veiga, Yunyun Yuan, Xuqin Li, Nuno C. Santos, Gang Liu*, and Miguel A. R. B. Castanho*, Why aren’t HIV-1 fusion inhibitors effective against SARS-CoV?, Biochimica Biophysica Acta (BBA), 2006, 1760, 55-61.
23. Hongbo Hu, Li Li , Richard Y. Kao, Binbin Kou, Zhanguo Wang, Liang Zhang, Huiyuan Zhang, Zhiyong Hao, Wayne H. Tsui, Anping Ni, Lianxian Cui, Baoxing Fan, Feng Guo, Shuan Rao, Chengyu Jiang, Qian Li, Manji Sun, Wei He*, Gang Liu*, Screening and Identification of Linear B-cell Epitopes and Entry Blocking Peptide of Severe Acute Respiratory Syndrome (SARS) Associated Coronavirus Using Synthetic Overlapping Peptide Library, Journal of Combinatorial Chemistry, 2005, 7, 648-656.
24. Jiang Zhang, Liang Zhang, Suode Zhang, Gang Liu*，Solution-Phase Parallel Synthesis of a Novel 1,2,7-trialkyl-1H-imidazo[4,5-g]quinoxalin-6-ol Library Scaffold, Journal of Combinatorial Chemistry, 2005, 7, 657-664.
25. Hong-Zhen Yang, Song Xu, Xue-Yan Liao, Suo-De Zhang, Zheng-Lun Liang, Bai-He Liu, Jin-Ye Bai, Chao Jiang, Jian Ding, Gui-Fang Cheng*, Gang Liu*, A novel immunostimulator, N2-[a-O-benzyl-N-(acetylmuramyl)-L-alanyl-D-isoglutaminyl]-N6-trans-(m-nitrocinnamoyl)-L-lysine (MDP-C), and its adjuvancy on the hepatitis B surface antigen, Journal of Medicinal Chemistry, 2005, 48, 5112-5122.
26. Nian-Huan Yao, Gang Liu,* Wen-Yi He, Changqun Niu, James R. Carlson, Kit S. Lam, Solid-phase synthesis and antibacterial evaluations of N-demethylvancomycin derivatives, Bioorg. & Med. Chem. Lett., 2005, 15(9): 2325-2329.
27. Nian-Huan Yao, Wen-Yi He, Kit S. Lam, and Gang Liu*, Conformational Studies of Resin-Bound Vancomycin and The Complex of Vancomycin and Ac2-L-Lys-D-Ala-D-Ala, Journal of Combinatorial Chemistry, 2005, 7, 123-129.
28. Li Li, Gang LIU*, Zhanguo Wang, Yunyun Yuan, Chunxu Zhang, Xianghong Wu, Jing Zhang, Multi-step parallel synthesis of substituted 5-aminobenzimidazoles in solution-phase, Journal of Combinatorial Chemistry, 2004, 6, 811-821.
29. Nian-Huan YAO, Wen-Yi HE, Kit S. LAM, Gang LIU*, Solid-Phase Synthesis of O-glycosylated Na-Fmoc Amino Acids and Analysis By The High Resolution Magic Angle Spinning NMR (HR/MAS NMR), Journal of Combinatorial Chemistry, 2004, 6, 214-219.
30. Xin-Mei Zhang, Gang Liu, Man-Ji Sun*, Anti-epitope antibody, a novel site-directed antibody against human acetylcholinesterase, Acta Pharmacol. Sin. 2004, 25(4): 431-435.
31. Liang ZHANG, Gang LIU*, Suo-De ZHANG, Xiang-Hong WU, Hong-Zhen YANG, Li LI, Gang-Chun SUN, Bin-Bin KOU, Song XU, Ya-Fei JI, Gui-Fang CHENG, Parallel approach for solution-phase synthesis of 2-quinoxalinol analogues and their inhibition of LPS-induced TNF-a release on mouse macrophage in vitro, Journal of Combinatorial Chemistry, 2004, 6, 431-436.
32. Xiang-Hong Wu, Gang Liu*, Jing Zhang, Zhan-Guo Wang, Song Xu, Suo-De Zhang, Liang Zhang, Lin Wang, Solution-phase reductive cyclization of 2-quinoxalinol analogs: systematic study of parallel synthesis, Molecular Diversity, 2004, 8 (2): 165-174.
33. Zhang Xing-mei, Li Qian, Wu Jun-hua, Shao Ning-sheng, Liu Gang, Sun Man-ji*, Specific oligobodies against human brain acetylcholinesterase", Brain Research, 2003, 989; 2: 147-151.
34. 贺文义，姚念环，LAM , Kit S.，刘刚*, 高分辨魔角核磁共振技术（HR/MAS）在固相合成中的应用，波谱学杂志，2003, 20(2): 201-208。
35. LIU XM, ZHANG DJ, CAO GJ, YANG G, DING HM, LIU G, FAN M, SHEN BF and SHAO NS*, RNA Aptamers Specific for Bovine Thrombin, Journal of Molecular Recognition, 2003, 16:23-27.
36. 刘刚*，范业梅，赵占工，Kit S LAM， “一珠一化合物”组合化学方法筛选抗万古霉素耐药菌活性化合物，中国药物化学杂志, 2002，12（6）：311-318。
37. Nagy SR, Liu G, Lam KS, Denison MS*, Identification of Novel Ah Receptor Agonists Using a High-Throughput Green Fluorescent Protein-Based Recombinant Cell Bioassay, Biochemistry, 2002, 41(3): 861-868.
38. Suo-De ZHANG, Gang LIU*, Shu-Quan XIA, Ping WU, Liang ZHANG, “Meshed-Bag Gathered-Bunch” method for solid-phase synthesis of small molecular diverse compounds, Journal of Combinatorial Chemistry, 2002, 4, 131-137.
39. Suo-De ZHANG, Gang LIU*, Su-Quan XIA, Ping WU, Design and synthesis of muramyl dipeptide cyclic analogue, Chinese Chemical Letters, 2002, 13(1), 17-18.
40. Suo-De ZHANG, Gang LIU*, Su-Quan XIA, Design and solid-phase synthesis of multiple muramyl dipeptide(MMD), Chinese Chemical Letters, 2001, 12(10): 887-888.
41. Xin-Mei ZHANG, Gang LIU, Man-Ji SUN*, Cross-immunoreactivity of synthetic antigenic decapeptides of human brain acetylcholinesterase with anti-Torpedo acetylcholinesterase polyclonal antibodies, Brain Research, 2001, 895(1-2): 277-282.
42. Xin-Mei ZHANG, Gang LIU, Man-Ji SUN*, Epitopes of human brain Acetylcholinesterase, Brain Research, 2000, 868: 157-164.
43. Gang LIU, Ye-Mei FAN, James R. CALSON, and Kit S. LAM*, Solution-phase synthesis of 1,5-dialkylamino-2,4-dinitrobenzene library and the identification of novel antibacterial compounds from this library, Journal of Combinatorial Chemistry, 2000, 2(5), 467-474.
44. Gang LIU*, Shuo-De ZHANG, Shu-Quan XIA, and Zhen-Kai DING, Solid-phase synthesis of muramyl dipeptide derivatives using Multipin method, Bioorg. & Med. Chem. Lett., 2000, 10, 1361-1363.
45. Gang LIU*, Shao-Feng MU, Liu-Hong YUN, Zhen-Kai DING, Man-Ji SUN, Systematic studies of the substituted active C-terminus of hirudin, Journal of Peptide Research, 1999, 54(6), 480-490.
参与编写和著书、导读：
1. Lin Wang , Tao Ma, and Gang Liu, Chapter 8: Recent Process in Calophyllum Coumarins as Potent Anti-HIV Agents, Medicinal Chemistry of Bioactive Products, edited by Profs. Xiao-tian Laing and Wei-shuo Fang, Wiley press, 2006, chapter 8, pg 325-351.
2. Gang LIU and Kit S. LAM, “One-bead one-compound combinatorial library method”, Combinatorial Chemistry, A Practical Approach, Edited by Hicham Fenniri, OXFORD University Press, 2000, Chapter 2, pp 33-50.
3. 刘刚，彦宇，导读“Comprehensive Medicinal Chemistry II”(Editors-in-Chief: Dr. John B Taylor and Professor David J Triggle)第三册：Drug Discovery Technologies. Edited by Professor Hugo Kubinyi.
4. 刘刚，萧晓毅等著，《寻找新药研究中的组合化学》，科学出版社，2003，6月。
5. 刘刚，组合化学与群集筛选，《中国药物研究与开发》，孙蔓霁主编，科学出版社，1996。
专利：
1. 消旋和光活胡桐素A及其类似物的制备方法，申请号：03123628.6。
2. 平行过滤箱，专利号：ZL03265620.3。
3. 消旋去甲胡桐素A制备抗爱滋病毒类药物中的应用及其与其他抗HIV-1抑制剂的联用，申请号：03142512.7。
4. 一种肽文库、其合成方法及从该文库中筛选的活性片段，申请号：200310101892.6。
5. Na-（1-a-苄基-N-乙酰基-胞壁酰-L-丙酰胺-D-异谷氨酰胺酰）-Ne（3-硝基-反式苯乙烯基）-L-赖氨酰胺、制法和其药物组合物与用途，申请号：200310101618.9。
6. 具有广泛交叉免疫反应性的冠状病毒（SARS-CoV）B-细胞抗原决定簇， 批准号：ZL200410073853.4。
7. 冠状病毒特异性T-细胞抗原决定簇，批准号：ZL200410074566.5。
8. 抗癌药物紫杉醇和免疫增强剂胞壁酰二肽(胞壁酰丙胺酰异谷胺酰胺)共轭物的制备及其活性，申请号：200410049667.7。
9. 四环双吡喃香豆素化合物及其抗HIV和抗结核菌用途, 申请号：PCT/CN7007/003139。
10. 胞壁酰二肽的类似物, 申请号：200610098615.8。
综述：
1、 韩春艳，李燕，刘刚，“似药性”：预测与实践，化学进展(Progress in Chemistry)，2008, 20(9),1335-1344.
2、 陈玉岩，刘刚，动态组合化学研究最新进展，化学进展(Progress in Chemistry)，2007，19（12）, 11903-1908。
3、 赵海燕，刘刚，苯并硫氮杂卓类化合物的研究进展，中国药物化学杂志，2007, 17（2）， 122-128。
4、 陈玉岩，刘刚，万古霉素衍生物的合成与活性研究进展(Recent Advances of Synthesis and Activity of Vancomycin Derivatives)，药学学报(Acta Pharmaceutica Sinica)，2007, 42(5), 463-469。
5、 杨天明，刘刚，吲哚及其类似物的药理活性和固相合成研究进展（Recent Progress in Pharmacological Activities and Solid-Phase Synthesis of Indoles and Analogues），药学学报 (Acta Pharmaceutica Sinica)，2006, 41(8), 694-701。
6、 张亮，刘刚，固载化试剂和催化剂及其在液相组合合成中的应用(Solid-Supported Reagents，Catalysts and Their Use in Solution-Phase Combinatorial Synthesis)，有机化学(Chinese Journal of Organic Chemistry)，2006，26（7），885-898。
7、 李旭琴，徐嵩，刘刚，天然产物衍生物化学库的组合合成研究进展(Recent developments in combinatorial synthesis of libraries of natural product analogues)，化学进展(Progress in Chemistry)，2006，18（9）, 1130-1142。
8、 张法，刘刚, 糖肽的固相合成(Solid-phase Synthesis of Glycopeptides), 化学进展(Progress in Chemistry)，2006，18（5），579-600。
9、 姚念环，贺文义，Kit S. LAM，刘刚, 核磁共振技术（NMR）在组合化学中的应用(Applications of Nuclear Magnetic Resonance Spectroscopy (NMR) to Combinational Chemistry)，化学进展(Progress in Chemistry)，2004, 16(5): 696-707。
刘刚老师相关教学资源
- 北京协和医学院教学资源
- 刘刚老师课程教学资源
