从1,500,000教师库中查找（输入学校名称或教师姓名）
张巍老师介绍
姓名：张巍 性别：女 职称：副主任医师
职务：无 招生院所：附属天坛医院
招生类型：专业学位(硕) 招生专业：神经病学(硕)
研究方向名称：神经变性疾病的基础与临床研究
电子信箱：ttyyzw@yahoo.com.cn
社会任职
1. 北京自然科学基金委员会评审专家
2. 《山东医药》（中国核心期刊）北京编委
个人简历
1. 198609-199107:中国医科大学 医疗系学士
2. 199108-199607:大连医科大学附属一院神经内科 住院医师
3. 199608-200107:大连医科大学附属一院神经内科 主治医师
4. 199709-200005:大连医科大学 神经病学硕士
5. 200108-200410:大连医科大学附属一院神经内科 副主任医师
6. 200109-200405:大连医科大学 神经生理学博士
7. 200207-200601:美国国立卫生研究院环境与健康研究所（NIEHS/NIH)) 神经生理学博士（联合培养），神经药理学博士后
8. 200604-200805:首都医科大学附属北京天坛医院神经内科 副主任医师
重要学术论文
1. Qian L, Xu Z, Zhang W, Wilson B, Hong JS, Flood PM*.Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase. J Neuroinflammation.. 2007, 4(1):23.SCI
2. Pei Z, Pang H, Qian L, Yang S, Wang T, Zhang W, Wu X, Dallas S, Wilson B, Reece JM, Miller DS, Hong JS, Block ML*.MAC1 mediates LPS-induced production of superoxide by microglia: The role of pattern recognition receptors in dopaminergic neurotoxicity. Glia. 2007,55(13):1362-1373.SCI
3. Zhang W, Dallas S, Zhang D, Guo JP, Pang H, Wilson B, Miller DS, Chen B, Zhang W, McGeer PL, Hong JS, Zhang J*.Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein. Glia. 2007,55(11):1178-1188.SCI
4. Wang T, Zhang W, Pei Z, Block M, Wilson B, Reece JM, Miller DS, Hong JS* .Reactive microgliosis participates in MPP+-induced dopaminergic neurodegeneration: role of 67 kDa laminin receptor. FASEB J. 2006,20(7):906-15.SCI
5. McLaughlin P, Zhou Y, Ma T, Liu J, Zhang W, Hong JS, Kovacs M, Zhang J*.Proteomic analysis of microglial contribution to mouse strain-dependent dopaminergic neurotoxicity. Glia. 2006,15;53(6):567-82.SCI
6. Yang S, Yang J, Yang Z, Chen P, Fraser A, Zhang W, Pang H, Gao X, Wilson B, Hong JS, Block ML*.Pituitary adenylate cyclase-activating polypeptide (PACAP) 38 and PACAP4-6 are neuroprotective through inhibition of NADPH oxidase: potent regulators of microglia-mediated oxidative stress. J Pharmacol Exp Ther. 2006,319(2):595-603.SCI
7. Zhang W, Shin EJ, Wang T, Lee PH, Pang H, Wie MB, Kim WK, Kim SJ, Huang WH, Wang Y, Zhang W, Hong JS, Kim HC*.3-Hydroxymorphinan, a metabolite of dextromethorphan, protects nigrostriatal pathway against MPTP-elicited damage both in vivo and in vitro. FASEB J. 2006,20(14):2496-511.SCI
8. Zhang W, Wang T, Pei Z, Miller DS, Wu X, Block ML, Wilson B, Zhang W, Zhou Y, Hong JS, Zhang J*.Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J. 2005,19(6):533-42.SCI
9. Zhang W, Qin L, Wang T, Wei SJ, Gao HM, Liu J, Wilson B, Liu B, Zhang W, Kim HC, Hong JS*.3-hydroxymorphinan is neurotrophic to dopaminergic neurons and is also neuroprotective against LPS-induced neurotoxicity. FASEB J. 2005,19(3):395-7.SCI
10. Qin L, Block ML, Liu Y, Bienstock RJ, Pei Z, Zhang W, Wu X, Wilson B, Burka T, Hong JS*.Microglial NADPH oxidase is a novel target for femtomolar neuroprotection against oxidative stress. FASEB J. 2005,19(6):550-7.SCI
11. Wu XF, Block ML, Zhang W, Qin L, Wilson B, Zhang WQ, Veronesi B, Hong JS*.The role of microglia in paraquat-induced dopaminergic neurotoxicity. Antioxid Redox Signal. 2005,7(5-6):654-61.SCI
12. Wang T, Pei Z, Zhang W, Liu B, Langenbach R, Lee C, Wilson B, Reece JM, Miller DS, Hong JS*.MPP+-induced COX-2 activation and subsequent dopaminergic neurodegeneration. FASEB J. 2005,19(9):1134-6.SCI
13. Zhang W, Wang T, Qin L, Gao HM, Wilson B, Ali SF, Zhang W, Hong JS, Liu B*.Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase. FASEB J . 2004,18(3):589-91.SCI
14. Wang T, Liu B, Zhang W, Wilson B, Hong JS*.Andrographolide reduces inflammation-mediated dopaminergic neurodegeneration in mesencephalic neuron-glia cultures by inhibiting microglial activation. J Pharmacol Exp Ther. 2004,308(3):975-83.SCI
15. Zhang W, Hong JS, Kim HC, Zhang W, Block ML*.Morphinan neuroprotection: new insight into the therapy of neurodegeneration. Crit Rev Neurobiol. 2004,16(4):271-302.SCI
16. 张巍, 雷征霖, 程艳杰，许晶，雷阳，高淑敏，袁宏，李士军，张万琴.血管性帕金森综合征患者抗心磷脂抗体变化及意义. 中国临床神经科学杂志. 2004,12（1):72 和107.无
17. 张巍, 雷征霖, 孙秀兰，宋春莉，许晶，雷阳，高淑敏，董晶琳，张万琴.帕金森病患者事件相关电位的变化及其临床意义. 中华神经科杂志. 2004,37（1）:70.无
18. Liu Y, Qin L, Li G, Zhang W, An L, Liu B, Hong JS*.Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation. J Pharmacol Exp Ther. 2003,305(1):212-8.SCI
19. 张巍, 雷征霖， 袁宏，程艳杰，李士军，张万琴.多发性脑梗死患者血清抗心磷脂抗体的变化及其临床意义. 中华老年医学杂志. 2001,20（2）:138.无
20. 张巍, 雷征霖, 宋春莉, 孙秀兰，许晶，董晶琳，张万琴.老年血管性帕金森综合征和帕金森病患者智能损害的对比研究及其临床意义的探讨. 中华老年医学杂志. 2001,20（3):218-219.无
21. 张巍, 雷征霖, 谷玲，李敬，张延军，蔡新霞，张华丽，杨春，张万琴.帕金森病患者血浆beta-内啡肽含量的变化及其临床意义. 中国神经免疫学和神经病学杂志. 2001,8（3):92-94.无
22. 张巍, 雷征霖, 张延军，谷玲，李敬，蔡新霞，张华丽，杨春，张万琴.血管性帕金森综合征患者血浆beta-内啡肽含量变化及其与痴呆和抑郁相关关系的研究. 中华神经科杂志. 2001,34（1）:61.无
23. 张巍, 梁战华，雷征霖.肌萎缩侧索硬化症合并帕金森病1例报告. 临床神经病学杂志. 2000,13（3）:164.无
24. 张巍, 雷征霖, 孙秀兰，宋春莉.血管性帕金森综合征和帕金森病患者智能与事件相关电位的对比研究. 脑与神经疾病杂志. 2000,8（4）:201-204.无
25. 张巍, 雷征霖, 张延军，谷玲，李敬，蔡新霞，张华丽，杨春，张万琴.血管性帕金森综合征患者血浆b-内啡肽的变化及其临床意义. 临床神经病学杂志. 2000,13（4）:213-215.无
26. 张巍， 许晶.急性脑血管病心电图分析及临床意义. 中国急救医学杂志. 2000,20（12）:728-729.无
27. 张巍，宋清伟，雷征霖，刘爱莲，王昭谦，李胜，王绍武，李广伟，李丽.血管性帕金森综合征和帕金森病患者头颅MRI和CT对比研究. 中华神经科杂志. 2000,33（4）:256.无
28. 张巍, 雷征霖, 孙秀兰，宋春莉.血管性帕金森综合征与帕金森病患者的临床对比分析. 中华神经科杂志. 2000,33（5）:285 和313.无
29. 张巍，雷征霖.血管性Parkinson综合征. 国外医学脑血管疾病分册. 1999,7（6）:348-351.无
主编或副主编的著作/译著
重要奖项
1. Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein 首都医科大学附属北京天坛医院“SCI影响因子第二名” 200712
2. 3-Hydroxymorphinan, a metabolite of dextromethorphan, protects nigrostriatal pathway against MPTP-elicited damage both in vivo and in vitro 首都医科大学附属北京天坛医院第15届王忠诚医学奖励基金一等奖 200709
3. 3-Hydroxymorphinan, a metabolite of dextromethorphan, protects nigrostriatal pathway against MPTP-elicited damage both in vivo and in vitro 首都医科大学附属北京天坛医院“最高SCI影响因子奖” 200612
4. 研究中脑黑质内小胶质细胞激活与帕金森病关系 辽宁省科技进步二等奖 200412
5. 帕金森病模型黑质多巴胺神经元变性与保护作用的靶点 教育部科技成果 200409
职务：无 招生院所：附属天坛医院
招生类型：专业学位(硕) 招生专业：神经病学(硕)
研究方向名称：神经变性疾病的基础与临床研究
电子信箱：ttyyzw@yahoo.com.cn
社会任职
1. 北京自然科学基金委员会评审专家
2. 《山东医药》（中国核心期刊）北京编委
个人简历
1. 198609-199107:中国医科大学 医疗系学士
2. 199108-199607:大连医科大学附属一院神经内科 住院医师
3. 199608-200107:大连医科大学附属一院神经内科 主治医师
4. 199709-200005:大连医科大学 神经病学硕士
5. 200108-200410:大连医科大学附属一院神经内科 副主任医师
6. 200109-200405:大连医科大学 神经生理学博士
7. 200207-200601:美国国立卫生研究院环境与健康研究所（NIEHS/NIH)) 神经生理学博士（联合培养），神经药理学博士后
8. 200604-200805:首都医科大学附属北京天坛医院神经内科 副主任医师
重要学术论文
1. Qian L, Xu Z, Zhang W, Wilson B, Hong JS, Flood PM*.Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase. J Neuroinflammation.. 2007, 4(1):23.SCI
2. Pei Z, Pang H, Qian L, Yang S, Wang T, Zhang W, Wu X, Dallas S, Wilson B, Reece JM, Miller DS, Hong JS, Block ML*.MAC1 mediates LPS-induced production of superoxide by microglia: The role of pattern recognition receptors in dopaminergic neurotoxicity. Glia. 2007,55(13):1362-1373.SCI
3. Zhang W, Dallas S, Zhang D, Guo JP, Pang H, Wilson B, Miller DS, Chen B, Zhang W, McGeer PL, Hong JS, Zhang J*.Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein. Glia. 2007,55(11):1178-1188.SCI
4. Wang T, Zhang W, Pei Z, Block M, Wilson B, Reece JM, Miller DS, Hong JS* .Reactive microgliosis participates in MPP+-induced dopaminergic neurodegeneration: role of 67 kDa laminin receptor. FASEB J. 2006,20(7):906-15.SCI
5. McLaughlin P, Zhou Y, Ma T, Liu J, Zhang W, Hong JS, Kovacs M, Zhang J*.Proteomic analysis of microglial contribution to mouse strain-dependent dopaminergic neurotoxicity. Glia. 2006,15;53(6):567-82.SCI
6. Yang S, Yang J, Yang Z, Chen P, Fraser A, Zhang W, Pang H, Gao X, Wilson B, Hong JS, Block ML*.Pituitary adenylate cyclase-activating polypeptide (PACAP) 38 and PACAP4-6 are neuroprotective through inhibition of NADPH oxidase: potent regulators of microglia-mediated oxidative stress. J Pharmacol Exp Ther. 2006,319(2):595-603.SCI
7. Zhang W, Shin EJ, Wang T, Lee PH, Pang H, Wie MB, Kim WK, Kim SJ, Huang WH, Wang Y, Zhang W, Hong JS, Kim HC*.3-Hydroxymorphinan, a metabolite of dextromethorphan, protects nigrostriatal pathway against MPTP-elicited damage both in vivo and in vitro. FASEB J. 2006,20(14):2496-511.SCI
8. Zhang W, Wang T, Pei Z, Miller DS, Wu X, Block ML, Wilson B, Zhang W, Zhou Y, Hong JS, Zhang J*.Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J. 2005,19(6):533-42.SCI
9. Zhang W, Qin L, Wang T, Wei SJ, Gao HM, Liu J, Wilson B, Liu B, Zhang W, Kim HC, Hong JS*.3-hydroxymorphinan is neurotrophic to dopaminergic neurons and is also neuroprotective against LPS-induced neurotoxicity. FASEB J. 2005,19(3):395-7.SCI
10. Qin L, Block ML, Liu Y, Bienstock RJ, Pei Z, Zhang W, Wu X, Wilson B, Burka T, Hong JS*.Microglial NADPH oxidase is a novel target for femtomolar neuroprotection against oxidative stress. FASEB J. 2005,19(6):550-7.SCI
11. Wu XF, Block ML, Zhang W, Qin L, Wilson B, Zhang WQ, Veronesi B, Hong JS*.The role of microglia in paraquat-induced dopaminergic neurotoxicity. Antioxid Redox Signal. 2005,7(5-6):654-61.SCI
12. Wang T, Pei Z, Zhang W, Liu B, Langenbach R, Lee C, Wilson B, Reece JM, Miller DS, Hong JS*.MPP+-induced COX-2 activation and subsequent dopaminergic neurodegeneration. FASEB J. 2005,19(9):1134-6.SCI
13. Zhang W, Wang T, Qin L, Gao HM, Wilson B, Ali SF, Zhang W, Hong JS, Liu B*.Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase. FASEB J . 2004,18(3):589-91.SCI
14. Wang T, Liu B, Zhang W, Wilson B, Hong JS*.Andrographolide reduces inflammation-mediated dopaminergic neurodegeneration in mesencephalic neuron-glia cultures by inhibiting microglial activation. J Pharmacol Exp Ther. 2004,308(3):975-83.SCI
15. Zhang W, Hong JS, Kim HC, Zhang W, Block ML*.Morphinan neuroprotection: new insight into the therapy of neurodegeneration. Crit Rev Neurobiol. 2004,16(4):271-302.SCI
16. 张巍, 雷征霖, 程艳杰，许晶，雷阳，高淑敏，袁宏，李士军，张万琴.血管性帕金森综合征患者抗心磷脂抗体变化及意义. 中国临床神经科学杂志. 2004,12（1):72 和107.无
17. 张巍, 雷征霖, 孙秀兰，宋春莉，许晶，雷阳，高淑敏，董晶琳，张万琴.帕金森病患者事件相关电位的变化及其临床意义. 中华神经科杂志. 2004,37（1）:70.无
18. Liu Y, Qin L, Li G, Zhang W, An L, Liu B, Hong JS*.Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation. J Pharmacol Exp Ther. 2003,305(1):212-8.SCI
19. 张巍, 雷征霖， 袁宏，程艳杰，李士军，张万琴.多发性脑梗死患者血清抗心磷脂抗体的变化及其临床意义. 中华老年医学杂志. 2001,20（2）:138.无
20. 张巍, 雷征霖, 宋春莉, 孙秀兰，许晶，董晶琳，张万琴.老年血管性帕金森综合征和帕金森病患者智能损害的对比研究及其临床意义的探讨. 中华老年医学杂志. 2001,20（3):218-219.无
21. 张巍, 雷征霖, 谷玲，李敬，张延军，蔡新霞，张华丽，杨春，张万琴.帕金森病患者血浆beta-内啡肽含量的变化及其临床意义. 中国神经免疫学和神经病学杂志. 2001,8（3):92-94.无
22. 张巍, 雷征霖, 张延军，谷玲，李敬，蔡新霞，张华丽，杨春，张万琴.血管性帕金森综合征患者血浆beta-内啡肽含量变化及其与痴呆和抑郁相关关系的研究. 中华神经科杂志. 2001,34（1）:61.无
23. 张巍, 梁战华，雷征霖.肌萎缩侧索硬化症合并帕金森病1例报告. 临床神经病学杂志. 2000,13（3）:164.无
24. 张巍, 雷征霖, 孙秀兰，宋春莉.血管性帕金森综合征和帕金森病患者智能与事件相关电位的对比研究. 脑与神经疾病杂志. 2000,8（4）:201-204.无
25. 张巍, 雷征霖, 张延军，谷玲，李敬，蔡新霞，张华丽，杨春，张万琴.血管性帕金森综合征患者血浆b-内啡肽的变化及其临床意义. 临床神经病学杂志. 2000,13（4）:213-215.无
26. 张巍， 许晶.急性脑血管病心电图分析及临床意义. 中国急救医学杂志. 2000,20（12）:728-729.无
27. 张巍，宋清伟，雷征霖，刘爱莲，王昭谦，李胜，王绍武，李广伟，李丽.血管性帕金森综合征和帕金森病患者头颅MRI和CT对比研究. 中华神经科杂志. 2000,33（4）:256.无
28. 张巍, 雷征霖, 孙秀兰，宋春莉.血管性帕金森综合征与帕金森病患者的临床对比分析. 中华神经科杂志. 2000,33（5）:285 和313.无
29. 张巍，雷征霖.血管性Parkinson综合征. 国外医学脑血管疾病分册. 1999,7（6）:348-351.无
主编或副主编的著作/译著
重要奖项
1. Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein 首都医科大学附属北京天坛医院“SCI影响因子第二名” 200712
2. 3-Hydroxymorphinan, a metabolite of dextromethorphan, protects nigrostriatal pathway against MPTP-elicited damage both in vivo and in vitro 首都医科大学附属北京天坛医院第15届王忠诚医学奖励基金一等奖 200709
3. 3-Hydroxymorphinan, a metabolite of dextromethorphan, protects nigrostriatal pathway against MPTP-elicited damage both in vivo and in vitro 首都医科大学附属北京天坛医院“最高SCI影响因子奖” 200612
4. 研究中脑黑质内小胶质细胞激活与帕金森病关系 辽宁省科技进步二等奖 200412
5. 帕金森病模型黑质多巴胺神经元变性与保护作用的靶点 教育部科技成果 200409
张巍老师相关教学资源
