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张宏冰老师介绍
张宏冰，三峡大学医学院临床医学本科,华中科技大学同济医学院心胸外科硕士，美国宾夕法尼亚大学（University of Pennsylvania）医学院博士,哈佛医学院博士后、讲师。现任中国医学科学院、北京协和医学院特聘教授，博士生导师，基础医学研究所生理和病理生理系、医学分子生物学国家重点实验室成员，为国家杰出青年科学基金获得者。在肿瘤与PI3K-AKT-TSC1/2-mTOR传导通路异常的研究作出了贡献,从分子水平上揭示了信号传递通路中不同水平上的改变可导致良性或恶性肿瘤。
目前研究方向：肿瘤的发生机制,早期诊断和靶向治疗
主要探讨细胞分化、细胞衰老、自噬、DNA损伤。并与协和医院肝脏外科合作研究肝癌的血清标记物的发现和应用，血清标记物的发生机制和生物学效应；与呼吸内科共同探讨PI3K-AKT-TSC-mTOR 信号传导通路在肺损伤和修复中的作用。
1. Zhang J., B. Wang, Z. Xiao, Y. Zhao, B. Chen, J. Han, Y. Gao, W. Ding，Zhang H, J. Dai. Olfactory ensheathing cells promote proliferation and inhibit neuronal differentiation of neural progenitor cells through activation of Notch1. Neuroscience 153： 406-413，2008
2. 毛一雷、杨华瑜、徐海峰、桑新亭、卢欣、杨志英、张锦春、钟守先、黄洁夫、张宏冰. 血清GP73具有肝癌诊断价值中华医学杂志2008年4月
3. Zhang H, Bajraszewski N, Wu E, Wang H, Moseman AP, Dabora SL, Griffin JD, Kwiatkowski DJ. PDGF receptors are critical for PI3K/AKT activation and negatively regulated by mTOR.J Clin Invest. 117: 730-738, 2007.
4. Chan JA, Zhang H, Roberts PS, Jozwiak S, Wieslawa G, Lewin-Kowalik J, Kotulska K, Kwiatkowski DJ. Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation. J Neuropathol Exp Neurol. 63:1236-42, 2004
5. El-Hashemite N, Zhang H, Walker V, Hoffmeister KM, Kwiatkowski DJ. Perturbed IFNg-Jak-stat signaling in tuberouse sclerosis mouse models: synergistic effects of rapamycin-IFNg treatment. Cancer Res 64: 3436-3443, 2004
6. Zhang H, Cicchetti G, Onda H, Koon HB, Asrikan K, Bajraszewski N, Vazquez P. Carpenter C, Kwiatkowski DJ. Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signalling throughdownregulation of PDGFR. J Clin Invest 112: 1223-33, 2003
7. El-Hashemite N, Walker V, Zhang H, Kwiatkowski DJ. Loss of tuberous sclerosis complex genes induces vascular endothelial growth factor production through mTOR pathway. Cancer Res 63: 5173-7, 2003
8. El-Hashemite N, Zhang H, Henske EP, Kwiatkowski DJ. Mutations in tuberous sclerosis complex-2 gene activate mammalian target of rapamycin (mTOR) downstream signaling pathway: a role in renal angiomyolipoma development. Lancet 361: 1348-9, 2003
9. Onda H, Crino P, Zhang H, Murphey R, Rastelli L, Rothberg BG, Kwiatkowski DJ. Tsc2 null murine neuronal epithelial cells are a model for human tuber giant cells, and show activation of an mTOR pathway. Mol Cell Neurosci 21: 561-574, 2002
10. Kwiatkowski DJ, Zhang H, Bandura JL, Heiberger KM, Onda H. A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in TSC1 null cells. Hum Mol Genet 11: 525-534, 2002
11. Zhang H, Somasundaram K, Peng Y, Tian H, Zhang H, Bi D, Weber BL, El-Deiry WS. BRCA1 physically associates with p53 and stimulates its transcriptional activity. Oncogene. 16: 1713-1721, 1998
12. Zhang HB, Tomblin G, Weber BL. BRCA1, BRCA2, and DNA Damage Response: Collision or Collusion? Cell 92, 433-436, 1998
13. Somasundaram K#, Zhang HB#, Zeng YX, Houvras Y, Peng Y, Zhang H, Wu GS, Licht JD, Weber BL, El-Deiry WS. BRCA1 inhibition of the cell cycle requires p21WAF1/CIP1. Nature 389, 187-190, 1997 (# equal contribution).
14. Thakur S, Zhang HB, Peng Y, Le H, Carroll B, Ward T, Yao J, Farid LM, Couch F, Wilson RB, Weber BL. Localization of BRCA1 and a splice variant identifies the nuclear localization signal. Mol. Cell. Bio., 17: 444-452, 1997
目前研究方向：肿瘤的发生机制,早期诊断和靶向治疗
主要探讨细胞分化、细胞衰老、自噬、DNA损伤。并与协和医院肝脏外科合作研究肝癌的血清标记物的发现和应用，血清标记物的发生机制和生物学效应；与呼吸内科共同探讨PI3K-AKT-TSC-mTOR 信号传导通路在肺损伤和修复中的作用。
1. Zhang J., B. Wang, Z. Xiao, Y. Zhao, B. Chen, J. Han, Y. Gao, W. Ding，Zhang H, J. Dai. Olfactory ensheathing cells promote proliferation and inhibit neuronal differentiation of neural progenitor cells through activation of Notch1. Neuroscience 153： 406-413，2008
2. 毛一雷、杨华瑜、徐海峰、桑新亭、卢欣、杨志英、张锦春、钟守先、黄洁夫、张宏冰. 血清GP73具有肝癌诊断价值中华医学杂志2008年4月
3. Zhang H, Bajraszewski N, Wu E, Wang H, Moseman AP, Dabora SL, Griffin JD, Kwiatkowski DJ. PDGF receptors are critical for PI3K/AKT activation and negatively regulated by mTOR.J Clin Invest. 117: 730-738, 2007.
4. Chan JA, Zhang H, Roberts PS, Jozwiak S, Wieslawa G, Lewin-Kowalik J, Kotulska K, Kwiatkowski DJ. Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation. J Neuropathol Exp Neurol. 63:1236-42, 2004
5. El-Hashemite N, Zhang H, Walker V, Hoffmeister KM, Kwiatkowski DJ. Perturbed IFNg-Jak-stat signaling in tuberouse sclerosis mouse models: synergistic effects of rapamycin-IFNg treatment. Cancer Res 64: 3436-3443, 2004
6. Zhang H, Cicchetti G, Onda H, Koon HB, Asrikan K, Bajraszewski N, Vazquez P. Carpenter C, Kwiatkowski DJ. Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signalling throughdownregulation of PDGFR. J Clin Invest 112: 1223-33, 2003
7. El-Hashemite N, Walker V, Zhang H, Kwiatkowski DJ. Loss of tuberous sclerosis complex genes induces vascular endothelial growth factor production through mTOR pathway. Cancer Res 63: 5173-7, 2003
8. El-Hashemite N, Zhang H, Henske EP, Kwiatkowski DJ. Mutations in tuberous sclerosis complex-2 gene activate mammalian target of rapamycin (mTOR) downstream signaling pathway: a role in renal angiomyolipoma development. Lancet 361: 1348-9, 2003
9. Onda H, Crino P, Zhang H, Murphey R, Rastelli L, Rothberg BG, Kwiatkowski DJ. Tsc2 null murine neuronal epithelial cells are a model for human tuber giant cells, and show activation of an mTOR pathway. Mol Cell Neurosci 21: 561-574, 2002
10. Kwiatkowski DJ, Zhang H, Bandura JL, Heiberger KM, Onda H. A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in TSC1 null cells. Hum Mol Genet 11: 525-534, 2002
11. Zhang H, Somasundaram K, Peng Y, Tian H, Zhang H, Bi D, Weber BL, El-Deiry WS. BRCA1 physically associates with p53 and stimulates its transcriptional activity. Oncogene. 16: 1713-1721, 1998
12. Zhang HB, Tomblin G, Weber BL. BRCA1, BRCA2, and DNA Damage Response: Collision or Collusion? Cell 92, 433-436, 1998
13. Somasundaram K#, Zhang HB#, Zeng YX, Houvras Y, Peng Y, Zhang H, Wu GS, Licht JD, Weber BL, El-Deiry WS. BRCA1 inhibition of the cell cycle requires p21WAF1/CIP1. Nature 389, 187-190, 1997 (# equal contribution).
14. Thakur S, Zhang HB, Peng Y, Le H, Carroll B, Ward T, Yao J, Farid LM, Couch F, Wilson RB, Weber BL. Localization of BRCA1 and a splice variant identifies the nuclear localization signal. Mol. Cell. Bio., 17: 444-452, 1997
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