宋正华 性别：女 民族：汉族
部门：分析化学学部
籍贯：山东 职称：教授/博士生导师 研究员
邮箱：songzhenghua@hotmail.com 电话： 029-88302604(O)
研究方向： 现代光化学分析,色谱分析和生物量热学的教学和科研工作
简 介
　　主要从事仪器分析的教学和科研工作。近年来在蛋白质,生物药物,环境有害物质和食品添加剂的流动注射发光分析，痕量物质的新技术,新方法的研究方面做了大量富有创新性的工作。2000年以来，主持陕西省自然科学基金项目和省教育厅科技研究项目5项；发表学术论文90余篇，其中在SCI源期刊发表学术论文60余篇；获陕西省政府科技进步叁等奖1项，陕西省环境保护贰等奖1项；编写研究生学位课英文教材Modern Optical Methods of Analysis,双语教材Introduction to Modern Analytical Chemistry等三部。宋正华老师所领导的分子光谱研究组，将开展蛋白质组学和食品分析方面的研究工作。该研究工作将以蛋白质与小分子的相互作用为依据，通过蛋白质超分子的光化学行为以及氧化还原性质，观察配体对活性蛋白的构象变化和表面特性的影响，阐明药物和有害物质对蛋白质的作用原理；建立快速测定蛋白质及痕量有害物质的新技术,新方法。
　　近年来,在SCI源期刊发表论文如下：
1. Zhuming Wang, Donghua Chen, Xin Gao, Zhenghua Song Sub-picogram Determination of Melamine in Milk Products Using Luminol-Myoglobin Chemiluminescence System, J. Agri. Food Chem., 2009, accepted.
2. Zhuming Wang, Xijuan Tan, Donghua Chen, Qiaoli Yue, Zhenghua Song, Study on the binding hehavior of lysozyme with cephalosporin analogues by fluorescence spectroscopy, J. Fluore., 2009, accepted.
3. Xin Li, Houyong Liu, Xili He, Zhenghua Song, Determination of cytochrome c in human serum and pharmaceutical injections using flow injection chemiluminescence, Appl. Biochem. Biotech., 2009, accepted.
4. Qiaoli Yue, Lichuan Niu, Xin Li, Xiaodong Shao, Xiaofeng Xie, Zhenghua Song, Study on the interaction mechanism of lysozyme and bromophenol blue by fluorescence spectroscopy, J. Fluore., 2008, 18, 11-15.
5. Qiaoli Yue, Zhenghua Song, Faxin Dong, Yanhong Liu, Xiaodong Shao, Photochemical behavior of lysozyme -4-(2-pyridylazo)-resorcinol polymolecular complex and its analytical applications, J. Fluore., 2007, 17, 505-511.
6. Xiaodong Shao, Xin Li, Bei Liu, Zhenghua Song, Determination of cefetamet pivoxil in human urine and serum using flow injection chemiluminescence procedure, J. Anal. Chem., 2009, 64(1), 71-74.
7. Houyong Liu, Xiaofei Gao, Lichuan Niu, Xin Li, Zhenghua Song, Rapid determination of picogram levels of patulin in apple juice using flow injection chmiluminescence procedure, J. Sci. Food Agric., 2008, 88, 2744-2748.
8. Qiaoli Yue, Zhenghua Song, Faxin Dong, A study on photochemical behavior of lysozyme-bromophenol blue complex and its analytical application, Spectrochim. Acta A, 2008, 69(4), 1097-1102.
8. Xiaofeng Xie, Xili He, Xiaoxiang Qiu, Zhenghua Song, In vitro monitoring chlorogenic acid in human urine and serum by a flow injection system exploiting the luminol-dissolved oxygen chemiluminescence reaction, Curr. Drug Metab., 2007, 8, 773-777.
10. Houyong Liu, Xili He, Cuihao Huang, Zhenghua Song, Sensitive chemiluminescence assay for patulin in apple juice by flow injection, Spectrosc. Lett., 2007, 40, 851-860.
11. Xiaodong Shao, Yanhong Liu, Xiaofei Gao, Wanqin Chen, Zhenghua Song, Determination of norfloxacin in pharmaceuticals, human serum and urine using a luminol-dissolved oxygen chemiluminescence system, Chem. Pap., 2007, 61(5), 1-6
12. Xiaofeng Xie, Xili He, Zhenghua Song, A sensitive chemiluminescence procedure for the determination of carbon monoxide with myoglobin-luminol chemiluminescence system, Appl. Spectrosc., 2007, 61(7), 706-710.
13. Xiaofei Gao, Houyong Liu, Zhenghua Song, Xili He, Faxin Dong, Rapid assay of pictogram level of sudan I in hot chilli sauce by flow injection chemiluminescence, Spectrosc-Int. J., 2007, 21, 135-141.
14. Xiaofeng Xie, Xiaodong Shao, Qiaoli Yue, Cuihao Huang, Zhenghua Song, Ultrasensitive assay of gatifloxacin at picogram level based on its enhancing effect on the myoglobin-luminol chemiluminescence reaction, Anal. Lett., 2007, 40, 1951-1961.
15. Xiaofeng Xie, Zhenghua Song, Xiaodong Shao, Determination of picomole amount of formaldehyde in air and bio-fluids based on its enhanced myoglobin-luminol chemiluminescence reaction using flow injection technique, Inter. J. Envir. Anal. Chem., 2007, 87, 149-157.
16. Yanhong Liu, Zhenghua Song, Faxin Dong, Flow injection chemiluminescence determination of sudanI in hot chilli sauce, J. Agri. Food Chem.,2007, 55, 614-617.
17. Xiaodong Shao, Xiaofeng Xie, Zhenghua Song, In vitro monitoring of clindamycin in human urine using flow injection chemiluminescence, Microchim. Acta, 2007, 157, 159-164.
18. Xin Gao, Yanhong Liu, Zhenghua Song, Catalytic effect of ferricyanide between myoglobin and luminol and notables effect of temperature, Luminescence, 2007, 22, 88-91.
19. Zhenghua Song, Yanhong Liu, Xiaofeng Xie, In vitro monitoring picogram roxithromycin in human urine using flow injection chemiluminescence procedure, Curr. Drug Metab., 2006, 7, 389-395.
20. Qiaoli Yue, Zhenghua Song, Rapid determination of sub-nanogram urapidil using flow injection enhancement chemiluminescence, J. Anal. Chem., 2006, 61(3), 295-299.
21. Xiaodong Shao, Xiaofeng Xie, Zhenghua Song, Rapid determination of clindamycin in medicine with myoglobin-luminol chemiluminescence system, J. Pharm. Biomed. Anal., 2006, 41, 667-670.
22. Yanhong Liu, Zhenghua Song, Flow injection chemiluminescence for determination of dopamine with immobilized reagents technology, Can. J. Anal. Sci. & Spect., 2006, 51(2), 59-66.
23. Zhenghua Song, Shuang Hou, Xiangyang Yu, In vitro monitoring of picogram levels of captopril in human urine using flow injection CL with immobilized reagent technique, Anal. Lett., 2006, 39(6), 1115-1127.
24. Zhenghua Song, Qiaoli Yue, Flow injection chemiluminescence determination of femtogram level cobalt in egg yolk, fish tissue and human serum, Food Chem., 2006, 94(3), 457-463.
25. Xiaodong Shao, Xiaofeng Xie, Zhenghua Song, Rapid determination of levofloxacin at nanogram level in pharmaceuticals and biological fluids using FI-CL, Curr. Anal. Chem., 2006, 2(3), 253-259.
26. Xiaofeng Xie, Zhenghua Song, Ultrasensitive determination of amoxicillin using chemiluminescence with flow injection analysis, Spectrosc-Int. J., 2006, 20, 37-43.
27. Qiaoli Yue, Zhenghua Song, Assay of femtogram level nitrite in human urine using luminol-myoglobin chemiluminescence, Microchem. J., 2006, 84, 1-13.
28. Xiaofeng Xie, Xiaodong Shao, Zhenghua Song, In vitro monitoring of risperidone at picogram level in human urine by luminol-H2O2 chemiluminescence, Chem. Pap., 2006, 60, 288-292.
29. Zhenghua Song, Qiaoli Yue, In vitro monitoring sub-nanogram vitamin C in human urine by chemiluminescence detection, Chemi. Anal., 2006, 51,449-507.
30. Zhenghua Song, Changna Wang, Determination of picogram-levels acetylspiramycin in human urine and serum by flow injection chemiluminescence, Microchim. Acta, 2005, 149(1-2), 117-122.
31. Zhenghua Song, Lin Wang, A study on chemiluminescence behavior of myoglobin with luminol and its analytical applications, Anal. Bioanal. Chem., 2004, 378(2), 529-535.
32. Changna Wang, Zhenghua Song, In vitro monitoring of nanogram levels of puerarin in human urine using flow injection chemiluminescence. Bioorg. Med. Chem. Lett., 2004, 14, 4127-4130.
33. Zhenghua Song, Qiaoli Yue, Changna Wang, Flow injection chemiluninescence for detecting picogram amounts of dobesilate in human urine. Spectrochim. Acta A, 2004, 60, 2377-2382.
34. Zhenghua Song, Changna Wang, Sensitive chemiluminescence assay for risperidone in pharmaceuticals and biological fluids with flow injection system, J. Pharm. Biomed. Chem., 2004, 36 (3), 491-494.
35. Zhenghua Song, Shuang Hou, A new analytical procedure for assay of lysozyme in human tears and saliva with immobilized reagents in flow injection CL system, Anal. Sci., 2003, 19(3), 347-352.
36. Zhenghua Song, Ni Zhang, FI-CL determination of reserpine in medicine and biological fluids with controlled-reagent-release technology, Chin. J. Chem., 2003, 21(2), 175-180.
37. Zhenghua Song, Ni Zhang, Chemiluminescence flow-through sensor for determination of reserpine in pharmaceutical preparation and biological fluids, Anal. Lett., 2003, 36(1), 41-47.
38. Zhenghua Song, Ni Zhang, In vitro detecting ultra trace novalgin in medicine and human urine by chemiluminescence, Talanta, 2003, 60, 161-170.
39. Zhenghua Song, Ni Zhang, A sensitive chemiluminescence flow injection procedure for assay of fluoride in waters and humane urine using immobilized reagents, Spectrosc. Lett., 2003, 36, 117-131.
40. Zhenghua Song, Ni Zhang, In vitro determination dobesilate in pharmaceutical preparations and human urine with chemiluminescence detection, Microchim. Acta, 2003, 142(4), 205-212.
41. Zhenghua Song, Shuang Hou, Sub-picogram determination of Vitamin B12 in pharmaceuticals and human serum using flow injection with chemiluminescence detection, Anal. Chim. Acta, 2003, 488(1), 71-79.
42. Zhenghua Song, Changna Wang, Ultrasensitive assay of azithromycin in medicine and bio-fluids based on its enhanced luminol-H2O2 chemiluminescence reaction, Bioorg. Med. Chem., 2003, 11, 5375-5380.
43. Zhenghua Song, Shuang Hou, On-line monitoring of formaldehyde in air using CL detection, Int. J. Environ. Anal. Chem., 2003, 83(9), 807-817.
44. Zhenghua Song, Lin Wang, Chemiluminescence inhibition assay for folic acid using flow injection analysis, Phytochem. Anal., 2003, 14, 216-220.
45. Zhenghua Song, Ni Zhang, In vitro monitoring sub-nanogram amounts analgin in human urine by its inhibitory of the luminol-periodate chemiluminescence system using reagent immobilization release technique, Bioorg. Med. Chem., 2002, 10(7), 2091-2097.
46. Zhenghua Song, Shuang Hou, Sensitive determination of sub-nanogram amounts of rutin by its inhibition on chemiluminescence with immobilized reagents, Talanta, 2002, 57, 59-67.
47. Zhenghua Song, Shuang Hou, Chemiluminescence assay for uric acid in human serum and urine using flow-injection, Anal. Bioanal. Chem., 2002, 372, 327-332.
48. Zhenghua Song, Shuang Hou, Determination of picomole amounts of thiamine through flow-injection analysis based on the suppression of luminol-KIO4 CL system, J. Pharm. Biomed. Anal., 2002, 28(3), 683-691.
49. Zhenghua Song, Shuang Hou, A new green analytical procedure for monitoring sub-nanogram amounts of chlorpyrifos, J. Agri. Food Chem., 2002, 50, 4468-4474.
50. Zhenghua Song, Shuang Hou, Flow-through sensor for the chemiluminescence determination of thiamine, Chem. Anal., 2002, 46, 747-757.
51. Zhenghua Song, Tiezhu Zhao, CL flow sensor for berberine with immobilized reagents, Bioorg. Med. Chem., 2001, 9(5), 1701-1705.
52. Zhenghua Song, Lin Wang, Chemiluminescence flow sensor for hydrazine with immobilized reagents, Anal. Lett., 2001, 34(3), 399-413.
53. Zhenghua Song, Lin Wang, Reagentless chemiluminescence flow sensor for the determination of riboflavin in pharmaceutical preparations and human urine, Analyst, 2001, 126(8), 1393-1398.
54. Zhenghua Song, Lin Wang, Chemiluminescence investigation of detection of rutin in medicine and human urine using flow sensor, J. Agri. Food Chem., 2001, 49(12), 5697-5701.
55. Zhenghua Song, Xin Zhou, Chemiluminescence flow sensor for folic acid with immobilized reagents, Spectrochim. Acta A, 2001, 57(11), 2567- 2574.
56. Zhenghua Song, Lin Wang, Resorcinol chemosensor based on detection of CL with immobilized reagent, Microchem. J., 2001, 68(1), 47-52.
57. Zhenghua Song, Jihong Lü, CL sensor for isoniazid with controlled- reagent-release technology, Talanta, 2001, 56(3), 1171-1177.
58. Zhenghua Song, Lin Wang, Determination of riboflavin using flow injection inhibitry chemiluminescence, Anal Lett., 2000, 33(13), 2767-2778.