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郑维发老师介绍
郑维发 教授，男，博士，徐州师范大学药用植物生物技术省重点实验室教授。1962年生，安徽南陵人。1986年获安徽师范大学生物系学士，1989年获华东师范大学生物系硕士。1993年在南京大学生物科学与技术系攻读博士学位，从事药用植物成分化学研究。1996年获博士学位并于该年9月在南京中医药大学从事博士后研究工作，开展植物药成分化学及其药理毒理学研究。1998年出站后在徐州师范大学资源生物实验室工作。该年9月当选为江苏省“333”工程科学技术与学术带头人、江苏省优秀青年骨干教师。2000年12月在江苏省药用植物生物技术重点实验室工作。2002年开始从事海洋微藻的生物学特性、代谢产物成分化学及其药理学研究。2006年11月至2007年5月在澳大利亚LaTrobe 大学生物工程研究中心从事真菌代谢产物调控研究。在真菌深层发酵及其代谢产物调控、海洋微藻的分离及其代谢产物调控、成分分析和药理学活性研究方面积累了较为丰富的经验，在国内外学术刊物上发表论文60余篇，申请专利12项，已有5项获得授权。先后主持教育部科学研究计划重点项目、海洋863重大专项、江苏省高校基础研究重大计划项目、江苏省自然科学基金等，近三年获得研究科研基金120万元。2005年在民间草药成分的分析与功能研究方面获国家教育部提名国家科学技术奖自然科学一等奖。2007年被中国自然科学核心期刊《菌物学报》、《微生物学通报》主编聘为专业审稿专家，负责这两个刊物的发酵、代谢产物成分化学、生物化学以及药理毒理学栏目的稿件审阅。
研究方向真菌深层发酵生物技术及其代谢产物的开发与应用。
主要代表作
1. Orr D, Zheng W, Campbell B, McDougall B, Seviour R. Culture conditions affecting the chemical composition of the exopolysaccharide synthesized by the fungus Aureobasidium pullulans. Journal of Applied Microbiology 2008, in press.
2. Accumulation of antioxidant phenolic constituents in submerged cultures of Inonotus obliquus. Bioresource Technology 2008, doi10.1016/j.biortech. 2008.05.002.
3. Zheng W, Campbell B, McDougall B, Seviour R Effects of melanin on the accumulation of exopolysaccharides by Aureobasidium pullulans grown on nitrate. Bioresource Technology 2008, 99 7480-7486
4. Zheng W, Zhao Y, Zhang M, Yin Z, Chen C, Wei Z. Phenolic compounds from Inonotus obliquus and their immune-stimulating effects. Mycosystema 2008, 27 39-47.
5. Zheng W, Zhang M, Zhao Y, Wang Y, Miao K, Wei Z. Accumulation of antioxidant phenolic constituents in submerged cultures of Inonotus obliquus. Bioresource Technology 2008, doi 10.1016/j.biortech.2008.05.002.
6. Gao X, Ge H, Zheng W, Tan X. NMR-based metabonomics for detection of Helicobacter pylori infection in Gerbils which is more descriptive? Helicobacter 13 103-111.
7. Zheng W, Xiang X, Chen C, Wang Y, Zhao Y, Jiang J, Chu C. Effects of culture media and three metal ions on the accumulation of lanosterol and ergosterol in cultured mycelia of Inonotus obliquus. Mycosystema 2008, 27 438-452
8. Zheng W, Liu T., Xiang X, Gu Q. Sterol composition in field-grown and cultured mycelia of Inonotus obliquus, Acta, Pharmaceutica Sinica, 2007, 42 (7)2-9
9. Zheng W, Gu Q, Chen C. Aminophenols and mold-water-extracts affect the accumulation of flavonoids and their antioxidant activity in cultured mycelia of Inonotus obliquus. Mycosystema, 2007 26 (3), 414-426
10. Chen C Zheng W, Gao X, Xiang X, Sun D, Wei C, Chu C. Aqueous extract of Inonotus obliquus (Fr.) Pilat (Hymenochaetace) significantly inhibits the growth of sarcoma 180 by inducing apoptosis. American Journal of Pharmacology and Toxicology 2007, 2 10-17.
11. Zheng W, Gao X, Chen C, Tan R. Total flavonoids of Daphne genkwa root significantly inhibit the growth and metastasis of Lewis Lung Carcinoma in C57BL6 mice. International Immunopharmacology 2007, 7 (2) 117-127.
12. Zheng W, Gao C, Gu Q, Chen C, Wei Z, Shi F. Antitumor activity of daphnodorins from Daphne genkwa roots International Immunopharmacology 2007, 7 (2) 127-134.
13. Zheng W, Chen C, Cheng Q, Wang Y, Chu C. Oral administration of exopolysaccharide from Aphanothece halophytica (Chroococcales) significantly inhibits influenza virus 4 (H1N1)-induced pneumonia in mice. International Immunopharmacology 2006, 6 1093-1099.
14. Zheng W, Chen C, Wang X, Bao K. Effects of potassium iodide on the growth and metabolite accumulation of two planktonic diatoms. Journal of Applied Phycology 2005, 17 355-362.
15. Cao D, Li M, Xue R, Zheng W, Liu Z, Wang X. Chronic administration of ethyl docosahexaenoate decreases mortality and cerebral edema in ischemic gerbils. Life Sciences, 2005, 78 (1) 74-81.
16. Zheng W, Shi F. Three new biflavones from ethanol extracts of the roots of Daphne genkwa. Acta Pharmaceutica Sinica 2005, 40 438-442
17. Cao D, Xu J, Xue R, Zheng W. Protective effect of chronic ethyl docosahexaenoate administration on brain injury in ischemic gerbils. Pharmacology, Biochemistry and Behavior, 2004, 79 651-659.
18. Zheng W, Shi F. Isolation and identification of a new dicoumarin from the roots of Daphne genkwa Sieb.et Zucc. Acta Pharmaceutica Sinica 2004, 39 990-992
19. Tan R, Zheng W, Tang H. Biologically active substances from Artemisia L. Planta Medica 1998, 64 295-302.
20. Tan R, Lu H, Wolfender J, Yu T, Zheng W, Yang L, Gafner G, Hostettmann K. Mono- and sesquiterpene lactones and antifungal constituents from Artemisia species. Planta Medica 1998, 64 234-236.
21. Zheng W, Cui Z, Zhu Q. Cytotoxicity and antiviral activity of the compounds from Euphorbia kansui. Planta Medica 1998, 64 754-756.
22. Zheng W, Tan R, Liu Z. Two flavones from Artemisia giraldii and their antimicrobial activity. Planta Medica 1996, 60 160-162.
23. Zheng W, Tan R, Liu Z. A new antimicrobial sesquiterpene lactone from Artemisia Giraldii. Spectroscopy Letters 1996, 29 1589-1597.
联系方式
办公地点药用植物生物技术重点实验室大楼3搂306室
电话0516-83403179 （O）
Emailyyzw@xznu.edu.cn， zheng.weifa@gmail.com
研究方向真菌深层发酵生物技术及其代谢产物的开发与应用。
主要代表作
1. Orr D, Zheng W, Campbell B, McDougall B, Seviour R. Culture conditions affecting the chemical composition of the exopolysaccharide synthesized by the fungus Aureobasidium pullulans. Journal of Applied Microbiology 2008, in press.
2. Accumulation of antioxidant phenolic constituents in submerged cultures of Inonotus obliquus. Bioresource Technology 2008, doi10.1016/j.biortech. 2008.05.002.
3. Zheng W, Campbell B, McDougall B, Seviour R Effects of melanin on the accumulation of exopolysaccharides by Aureobasidium pullulans grown on nitrate. Bioresource Technology 2008, 99 7480-7486
4. Zheng W, Zhao Y, Zhang M, Yin Z, Chen C, Wei Z. Phenolic compounds from Inonotus obliquus and their immune-stimulating effects. Mycosystema 2008, 27 39-47.
5. Zheng W, Zhang M, Zhao Y, Wang Y, Miao K, Wei Z. Accumulation of antioxidant phenolic constituents in submerged cultures of Inonotus obliquus. Bioresource Technology 2008, doi 10.1016/j.biortech.2008.05.002.
6. Gao X, Ge H, Zheng W, Tan X. NMR-based metabonomics for detection of Helicobacter pylori infection in Gerbils which is more descriptive? Helicobacter 13 103-111.
7. Zheng W, Xiang X, Chen C, Wang Y, Zhao Y, Jiang J, Chu C. Effects of culture media and three metal ions on the accumulation of lanosterol and ergosterol in cultured mycelia of Inonotus obliquus. Mycosystema 2008, 27 438-452
8. Zheng W, Liu T., Xiang X, Gu Q. Sterol composition in field-grown and cultured mycelia of Inonotus obliquus, Acta, Pharmaceutica Sinica, 2007, 42 (7)2-9
9. Zheng W, Gu Q, Chen C. Aminophenols and mold-water-extracts affect the accumulation of flavonoids and their antioxidant activity in cultured mycelia of Inonotus obliquus. Mycosystema, 2007 26 (3), 414-426
10. Chen C Zheng W, Gao X, Xiang X, Sun D, Wei C, Chu C. Aqueous extract of Inonotus obliquus (Fr.) Pilat (Hymenochaetace) significantly inhibits the growth of sarcoma 180 by inducing apoptosis. American Journal of Pharmacology and Toxicology 2007, 2 10-17.
11. Zheng W, Gao X, Chen C, Tan R. Total flavonoids of Daphne genkwa root significantly inhibit the growth and metastasis of Lewis Lung Carcinoma in C57BL6 mice. International Immunopharmacology 2007, 7 (2) 117-127.
12. Zheng W, Gao C, Gu Q, Chen C, Wei Z, Shi F. Antitumor activity of daphnodorins from Daphne genkwa roots International Immunopharmacology 2007, 7 (2) 127-134.
13. Zheng W, Chen C, Cheng Q, Wang Y, Chu C. Oral administration of exopolysaccharide from Aphanothece halophytica (Chroococcales) significantly inhibits influenza virus 4 (H1N1)-induced pneumonia in mice. International Immunopharmacology 2006, 6 1093-1099.
14. Zheng W, Chen C, Wang X, Bao K. Effects of potassium iodide on the growth and metabolite accumulation of two planktonic diatoms. Journal of Applied Phycology 2005, 17 355-362.
15. Cao D, Li M, Xue R, Zheng W, Liu Z, Wang X. Chronic administration of ethyl docosahexaenoate decreases mortality and cerebral edema in ischemic gerbils. Life Sciences, 2005, 78 (1) 74-81.
16. Zheng W, Shi F. Three new biflavones from ethanol extracts of the roots of Daphne genkwa. Acta Pharmaceutica Sinica 2005, 40 438-442
17. Cao D, Xu J, Xue R, Zheng W. Protective effect of chronic ethyl docosahexaenoate administration on brain injury in ischemic gerbils. Pharmacology, Biochemistry and Behavior, 2004, 79 651-659.
18. Zheng W, Shi F. Isolation and identification of a new dicoumarin from the roots of Daphne genkwa Sieb.et Zucc. Acta Pharmaceutica Sinica 2004, 39 990-992
19. Tan R, Zheng W, Tang H. Biologically active substances from Artemisia L. Planta Medica 1998, 64 295-302.
20. Tan R, Lu H, Wolfender J, Yu T, Zheng W, Yang L, Gafner G, Hostettmann K. Mono- and sesquiterpene lactones and antifungal constituents from Artemisia species. Planta Medica 1998, 64 234-236.
21. Zheng W, Cui Z, Zhu Q. Cytotoxicity and antiviral activity of the compounds from Euphorbia kansui. Planta Medica 1998, 64 754-756.
22. Zheng W, Tan R, Liu Z. Two flavones from Artemisia giraldii and their antimicrobial activity. Planta Medica 1996, 60 160-162.
23. Zheng W, Tan R, Liu Z. A new antimicrobial sesquiterpene lactone from Artemisia Giraldii. Spectroscopy Letters 1996, 29 1589-1597.
联系方式
办公地点药用植物生物技术重点实验室大楼3搂306室
电话0516-83403179 （O）
Emailyyzw@xznu.edu.cn， zheng.weifa@gmail.com
郑维发老师相关教学资源
- 徐州师范大学教学资源
- 郑维发老师课程教学资源
