姓名: 桂玉
性别：女
职称：教授
学科方向：心血管药理
招生方向： 药理学
教师简介
2002年毕业于University of Calgary, Canada。 获博士学位（心血管药理专业）。2003年至2008年10月在University of Calgary生化和分子生物学系从事博士后工作。2008年11月在该校药理系任研究助理教授。2009年3月回到南开大学工作。负责《药理学》课程。科研工作主要注重于探讨药物对血管平滑肌收缩功能以及平滑肌细胞增生和细胞周期调控的作用及其机理。
代表性作品：
1. GUI, Y., ZHENG, X.L. ZHENG, J., WALSH, M.P. Inhibition of rat aortic smooth muscle contraction by 2-Methoxyestradiol American Journal of Physiology Heart Circ Physiol. 295(5): H1935-42. 2008
2. GUI, Y., WALSH, M.P., Jankowski, J., Jankowski V., ZHENG, X.L Up4A stimulates endothelium-independent contraction in rat pulmonary artery American Journal of Physiology Cell Mol Physiol. 294(4): L733-8. 2008
3. GUI, Y., HE, G., WALSH, M. P., ZHENG, X. L. Predisposition to tetraploidy in pulmonary vascular smooth muscle cells derived from the Eker rats American Journal of Physiology Lung Cell Mol Physiol. 293(3): L702-11. 2007
4. JANKOWSKI, V., MEYER, A., SCHLATTMANN, P., GUI, Y., ZHENG, X. L., STAMCOU, I., RADTKE, K., ANHTRAN, T., VAN DER GIET, M., ZIDEK, W., JANKOWSKI, J. Increased uridine adenosine tetraphosphate concentrations in plasma of juvenile hypertensives. Arteriosclerosis, Thrombosis, and Vascular Biology 27(8): 1776-81 2007
5. GUI, Y., HE, J. Y., YIN, H., YANG, S. H., WALSH, M. P., ZHENG, X.L. Endoreduplication of human smooth muscle cells induced by 2-Methoxyestradiol: A potential role for cyclin-dependent kinase 2 American Journal of Physiology Heart Circ Physiol. 292(3): H1313-20. 2007
6. GUI, Y. & ZHENG, X. L. 2-Methoxyestradiol induces cell cycle arrest and mitotic cell apoptosis in human vascular smooth muscle cells. Hypertension 47: 271-280, 2006
7. ZHENG, X. L., GUI, Y., DU, G., FROHMAN, M. A., PENG, D. Q. Calphostin-C induction of vascular smooth muscle cell apoptosis proceeds through phospholipase D and microtubule inhibition. Journal of Biological Chemistry 279: 7112-7118, 2004
8. GUI, Y. & ZHENG, X. L. Epidermal growth factor induction of phenotype-dependent cell cycle arrest in vascular smooth muscle cells is through the mitogen-activated protein kinase pathway. Journal of Biological Chemistry 278: 53017-53025, 2003
9. GUI, Y., LOUTZENHISER, R., HOLLENBERG, M. D. Bidirectional regulation of renal hemodynamics by activation of PAR1 and PAR2 in isolated perfused rat kidney. American Journal of Physiology Renal Physiol. 285: F95-F104, 2003
10. TROTTIER, G., HOLLENBERG, M. D., WANG, X., GUI, Y., LOUTZENHISER, K. and LOUTZENHISER, R. PAR-2 elicits afferent arteriolar vasodilation by NO-dependent and NO-independent actions. American Journal of Physiology Renal Physiol. 282: F891-F897, 2002
11. GUI, Y., ZHENG, X. L., HOLLENBERG, M. D. Interleukin-1b, Src-and non-Src tyrosine kinases, and nitric oxide synthase induction in rat aorta in vitro. American Journal of Physiology Heart Circ Physiol. 279: H566-H576, 2000
12. ZHENG, X. L., GUI, Y., SHARKEY, K. A., HOLLENBERG, M. D. Differential induction of nitric oxide synthase in rat gastric and vascular smooth muscle tissue: distinct tissue distribution and distinctive signaling pathways. Journal of Pharmacology & Experimental Therapeutics 289: 632-640, 1999
13. HOLLENBERG, M. D., SAIFEDDINE, M., AL-ANI, B., GUI, Y. Proteinase-activated receptor-4 (PAR4): action of PAR4-activated peptides in vascular and gastric tissue and lack of cross-reactivity with PAR1 and PAR2. Canadian Journal of Physiology and Pharmacology 77: 458-464, 1999
Book & Charpters Published:
1. HOLLENBERG, M. D., SIJESURIYA, S. J., GUI, Y., LOUTZENHIZER, R. Proteinase-activated receptors(PARs) and the kidney. Drug Devel. Res. 60:36 – 42, 2003
2. MAGUIRE, J. J., GUI, Y., WANG, X., LOUTZENHISER, R., TRIGGLE, C. R. and HOLLENBERG, M. D. Proteinase-activated receptor-2 (PAR2): release of an endothelium-derived hyperplorizing factor distict from that released by acetycholine EDHF 2002:47 – 54, Ed. P. M. Vanhoutte, Taylor & Francis, London, England, 2002
通讯地址: 南开大学药学院 天津市卫津路94号300071
电话: 15022247282
传真：022-23507760
电子邮件： ygui@ucalgary.ca