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李秋荣老师介绍
姓名：李秋荣
研究方向：临床营养支持
联系方式（Email)：liqiurong@yahoo.com
个人简介：
南京大学医学院教授、博士生导师。1997年毕业于哈尔滨医科大学获医学博士学位，同年进入中国科学院沈阳应用生态研究所生物学科博士后流动站从事博士后研究工作。1999年至2001年在德国亚琛工大（Rheinisch-Westf?lisch Technische Hochschule）分子生物技术研究所，从事分子生物学领域的研究工作。回国后主持并参与多项国家自然科学基金、国家“973计划”、江苏省自然科学基金等国家和省级重点研究项目。近年主要研究工作的重点是胃肠功能障碍疾病发生发展的生理病理学分子机理的研究，包括小肠移植慢性失功和感染状态下肠屏障功能损伤和细菌易位途径的分子机制研究。
代表性成果（专业成果、学术论文、学术专著等）：
【1】Qiurong Li, Qiang Zhang, Chenyang Wang, Linlin Qu, Lili Gu, Xiaoxiang Liu, Ning Li, Jieshou Li. Altered distribution of tight junction proteins after intestinal ischemia/reperfusion injury in rats. Journal of Cellular and Molecular Medicine 2009, in press
【2】Qiurong Li, Qiang Zhang, Chenyang Wang, Xiaoxiang Liu, Ning Li, and Jieshou Li. Disruption of tight junctions during polymicrobial sepsis in vivo. Journal of Pathology 2009, 218: 210-221.
【3】Qiurong Li, Qiang Zhang, Chenyang Wang, Yuanxin Li, Bo Wu, Xiaoxiang Liu, Yousheng Li, Ning Li, Jieshou Li. Alteration of tight junctions in intestinal transplantation induced by Campath-1H. Clinical Immunology 2009, 132: 141-143
【4】Qiurong Li, Qiang Zhang, Meng Wang, Sumin Zhao, Guowang Xu, Jieshou Li. n-3 polyunsaturated fatty acids prevent disruption of epithelial barrier function induced by proinflammatory cytokines. Molecular Immunology 2008, 45:1356-1365.
【5】Qiurong Li, Qiang Zhang, Meng Wang, Sumin Zhao , Jian Ma, Nan Luo, Ning Li, Yousheng Li, Guowang Xu, Jieshou Li. Interferon-γ and tumor necrosis factor-α disrupt epithelial barrier function by altering lipid composition in membrane microdomains of tight junction. Clinical Immunology 2008, 126: 67-80.
【6】Qiurong Li, Qiang Zhang, Min Zhang, Chenyang Wang, Zhenxin Zhu, Ning Li and Jieshou Li. Effect of n-3 polyunsaturated fatty acids on membrane microdomain localization of tight junction proteins in experimental colitis. FEBS Journal 2008, 275: 411-420.
【7】Qiurong Li, Qiang Zhang, Chenyang Wang, Ning Li, Jieshou Li. Invasion of enteropathogenic Escherichia coli into host cells through epithelial tight junctions. FEBS Journal 2008, 275: 6022-6032.
【8】Qiurong Li, Qiang Zhang, Guowang Xu, Peiyuan Yin, Ning Li, and Jieshou Li. Metabonomics Study of Intestinal Transplantation Using UPLC Q-TOF Mass Spectrometry. Digestion 2008, 77: 122-130.
【9】Qiurong Li, Qiang Zhang, Meng Wang, Sumin Zhao , Jian Ma, Nan Luo, Ning Li , Yousheng Li, Guowang Xu, Jieshou Li. Eicosapentaenoic acid modifies lipid composition in caveolae and induces translocation of endothelial nitric oxide synthase. Biochimie 2007, 89: 169-177.
【10】Qiurong Li, Qiang Zhang, Meng Wang, Fuzhong Liu, Sumin Zhao , Jian Ma, Nan Luo, Ning Li , Yousheng Li, Guowang Xu, Jieshou Li. Docosahexaenoic acid affects endothelial nitric oxide synthase in caveolae. Archives of Biochemistry and Biophysics 2007, 466: 250-259.
【11】M Wang, N Li, Q Zhang, J Ma, and Q Li*. Acute influence of FK506 on T-lymphocyte populations of peripheral blood and spleen in rats. Transplantation Proceedings 2007, 39:292–294.
【12】Qiurong Li, Li Tan, Chang Wang, Ning Li, Yousheng Li, Guowang Xu, and Jieshou Li. Polyunsaturated eicosapentaenoic acid changes lipid composition in lipid rafts. European Journal of Nutrition 2006, 45:144-151.
【13】Peiyuan Yin, Xinjie Zhao, Qiurong Li, Jiangshan Wang, Jieshou Li, and Guowang Xu. Metabonomics study of intestinal fistulas based on ultraperformance liquid chromatography coupled with Q-TOF mass spectrometry (UPLC/Q-TOF MS). Journal of Proteome Research 2006, 5: 2135-2143.
【14】Qiurong Li, Meng Wang, Li Tan, Chang Wang, Jian Ma, Ning Li, Yousheng Li, Guowang Xu, and Jieshou Li. Polyunsaturated Docosahexaenoic Acid Changes Lipid Composition and IL-2 Receptor Signaling in Raft. Journal of Lipid Research 2005, 46: 1904-1913.
【15】Qiurong Li, Jian Ma, Hao Wang, and Jieshou Li. Interleukin-2 Receptor in Membrane Lipid Rafts. Transplantation Proceedings 2005, 37: 2395-2397.
【16】Qiurong Li，Stefano Di Fiore, Rainer Fischer, Miao Wang. Expression of tryptophan decarboxylase in the chloroplasts of transgenic tobacco plants. Botanica Bull Acad Sin 2003, 44:193-198.
【17】Stefano Di Fiore, Qiurong Li, Mark James Leech, Flora Schuster, Neil Emans, Rainer Fischer, and Stefan Schillberg. Targeting tryptophan decarboxylase to selected subcellular compartments of tobacco plants affects enzyme stability and in vivo function and leads to a lesion-mimic phenotype. Plant Physiology 2002, 129: 1160-1169.
科研项目：
【1】国家自然科学基金面上项目：小肠移植肠黏膜屏障功能与紧密连接膜微区域（30672061）
【2】全军医学科学技术研究“十一五”课题：n-3多不饱和脂肪酸与紧密连接微区域蛋白移位（0603AM117）
【3】南京军区“十一五”重点课题：肠黏膜屏障功能损伤与肠黏膜上皮细胞紧密连接微区域的改变（06Z40）
【4】国家重点基础研究发展计划“973”计划：脂类分子代谢对移植物慢性失功的影响 （2009CB522405）
研究方向：临床营养支持
联系方式（Email)：liqiurong@yahoo.com
个人简介：
南京大学医学院教授、博士生导师。1997年毕业于哈尔滨医科大学获医学博士学位，同年进入中国科学院沈阳应用生态研究所生物学科博士后流动站从事博士后研究工作。1999年至2001年在德国亚琛工大（Rheinisch-Westf?lisch Technische Hochschule）分子生物技术研究所，从事分子生物学领域的研究工作。回国后主持并参与多项国家自然科学基金、国家“973计划”、江苏省自然科学基金等国家和省级重点研究项目。近年主要研究工作的重点是胃肠功能障碍疾病发生发展的生理病理学分子机理的研究，包括小肠移植慢性失功和感染状态下肠屏障功能损伤和细菌易位途径的分子机制研究。
代表性成果（专业成果、学术论文、学术专著等）：
【1】Qiurong Li, Qiang Zhang, Chenyang Wang, Linlin Qu, Lili Gu, Xiaoxiang Liu, Ning Li, Jieshou Li. Altered distribution of tight junction proteins after intestinal ischemia/reperfusion injury in rats. Journal of Cellular and Molecular Medicine 2009, in press
【2】Qiurong Li, Qiang Zhang, Chenyang Wang, Xiaoxiang Liu, Ning Li, and Jieshou Li. Disruption of tight junctions during polymicrobial sepsis in vivo. Journal of Pathology 2009, 218: 210-221.
【3】Qiurong Li, Qiang Zhang, Chenyang Wang, Yuanxin Li, Bo Wu, Xiaoxiang Liu, Yousheng Li, Ning Li, Jieshou Li. Alteration of tight junctions in intestinal transplantation induced by Campath-1H. Clinical Immunology 2009, 132: 141-143
【4】Qiurong Li, Qiang Zhang, Meng Wang, Sumin Zhao, Guowang Xu, Jieshou Li. n-3 polyunsaturated fatty acids prevent disruption of epithelial barrier function induced by proinflammatory cytokines. Molecular Immunology 2008, 45:1356-1365.
【5】Qiurong Li, Qiang Zhang, Meng Wang, Sumin Zhao , Jian Ma, Nan Luo, Ning Li, Yousheng Li, Guowang Xu, Jieshou Li. Interferon-γ and tumor necrosis factor-α disrupt epithelial barrier function by altering lipid composition in membrane microdomains of tight junction. Clinical Immunology 2008, 126: 67-80.
【6】Qiurong Li, Qiang Zhang, Min Zhang, Chenyang Wang, Zhenxin Zhu, Ning Li and Jieshou Li. Effect of n-3 polyunsaturated fatty acids on membrane microdomain localization of tight junction proteins in experimental colitis. FEBS Journal 2008, 275: 411-420.
【7】Qiurong Li, Qiang Zhang, Chenyang Wang, Ning Li, Jieshou Li. Invasion of enteropathogenic Escherichia coli into host cells through epithelial tight junctions. FEBS Journal 2008, 275: 6022-6032.
【8】Qiurong Li, Qiang Zhang, Guowang Xu, Peiyuan Yin, Ning Li, and Jieshou Li. Metabonomics Study of Intestinal Transplantation Using UPLC Q-TOF Mass Spectrometry. Digestion 2008, 77: 122-130.
【9】Qiurong Li, Qiang Zhang, Meng Wang, Sumin Zhao , Jian Ma, Nan Luo, Ning Li , Yousheng Li, Guowang Xu, Jieshou Li. Eicosapentaenoic acid modifies lipid composition in caveolae and induces translocation of endothelial nitric oxide synthase. Biochimie 2007, 89: 169-177.
【10】Qiurong Li, Qiang Zhang, Meng Wang, Fuzhong Liu, Sumin Zhao , Jian Ma, Nan Luo, Ning Li , Yousheng Li, Guowang Xu, Jieshou Li. Docosahexaenoic acid affects endothelial nitric oxide synthase in caveolae. Archives of Biochemistry and Biophysics 2007, 466: 250-259.
【11】M Wang, N Li, Q Zhang, J Ma, and Q Li*. Acute influence of FK506 on T-lymphocyte populations of peripheral blood and spleen in rats. Transplantation Proceedings 2007, 39:292–294.
【12】Qiurong Li, Li Tan, Chang Wang, Ning Li, Yousheng Li, Guowang Xu, and Jieshou Li. Polyunsaturated eicosapentaenoic acid changes lipid composition in lipid rafts. European Journal of Nutrition 2006, 45:144-151.
【13】Peiyuan Yin, Xinjie Zhao, Qiurong Li, Jiangshan Wang, Jieshou Li, and Guowang Xu. Metabonomics study of intestinal fistulas based on ultraperformance liquid chromatography coupled with Q-TOF mass spectrometry (UPLC/Q-TOF MS). Journal of Proteome Research 2006, 5: 2135-2143.
【14】Qiurong Li, Meng Wang, Li Tan, Chang Wang, Jian Ma, Ning Li, Yousheng Li, Guowang Xu, and Jieshou Li. Polyunsaturated Docosahexaenoic Acid Changes Lipid Composition and IL-2 Receptor Signaling in Raft. Journal of Lipid Research 2005, 46: 1904-1913.
【15】Qiurong Li, Jian Ma, Hao Wang, and Jieshou Li. Interleukin-2 Receptor in Membrane Lipid Rafts. Transplantation Proceedings 2005, 37: 2395-2397.
【16】Qiurong Li，Stefano Di Fiore, Rainer Fischer, Miao Wang. Expression of tryptophan decarboxylase in the chloroplasts of transgenic tobacco plants. Botanica Bull Acad Sin 2003, 44:193-198.
【17】Stefano Di Fiore, Qiurong Li, Mark James Leech, Flora Schuster, Neil Emans, Rainer Fischer, and Stefan Schillberg. Targeting tryptophan decarboxylase to selected subcellular compartments of tobacco plants affects enzyme stability and in vivo function and leads to a lesion-mimic phenotype. Plant Physiology 2002, 129: 1160-1169.
科研项目：
【1】国家自然科学基金面上项目：小肠移植肠黏膜屏障功能与紧密连接膜微区域（30672061）
【2】全军医学科学技术研究“十一五”课题：n-3多不饱和脂肪酸与紧密连接微区域蛋白移位（0603AM117）
【3】南京军区“十一五”重点课题：肠黏膜屏障功能损伤与肠黏膜上皮细胞紧密连接微区域的改变（06Z40）
【4】国家重点基础研究发展计划“973”计划：脂类分子代谢对移植物慢性失功的影响 （2009CB522405）
李秋荣老师相关教学资源
