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李尧华老师介绍
姓名：李尧华 性别：男 职称：副研究员
职务： 招生院所：附属宣武医院
招生类型：科学学位(硕) 招生专业：神经生物学(硕)
研究方向名称：帕金森病相关蛋白质的功能与代谢
电子信箱：liyaohua@chinapd.cn
社会任职
个人简历
1. 197908-198408:吉林医学院医学系 学习
2. 198408-199609:吉林医学院医学系生物化学教研室 助教、讲师
3. 199010-199110:日本大阪大学医学部第三内科 留学
4. 199609-200103:日本滋贺医科大学代谢调节系生物化学第二讲座 博士课程
5. 200103-200303:首都医科大学宣武医院老年病研究所 博士后
6. 200303-200806:首都医科大学宣武医院老年病研究所 副研究员
重要学术论文
1. 刘光伟，殷娟娟，张春岩，李昕，刘耀波，李尧华，杨慧，陈彪，于顺*.a-突触核蛋白存在于大鼠脑线粒体中. 首都医科大学学报. 2007,28（3）:328-332.无
2. 李昕，于顺，李尧华*.重组大鼠a突触核蛋白的制备与鉴定. 首都医科大学学报. 2007,28（6）:333-336.无
3. 高楠，李尧华*，李昕，于顺，傅桂莲，陈彪.Effect of a-synuclein on the promoter activity of tyrosine hydroxylase gene. Neuroscience Bulletin. 2007,23(1):53-57.无
4. 殷娟娟，韩俊艳，李昕，李尧华，刘耀波，于顺*.a突触核蛋白功能片段向多巴胺能神经细胞内的转运及其对细胞增殖的影响. 首都医科大学学报. 2007,28（3）:345-349.无
5. 李昕，李尧华*，韩俊燕，于顺，陈彪.cDNA cloning, prokaryotic expression and purification of rat a-synuclein. Neuroscience Bulletin. 2006,22(1):29-33.无
6. 韩俊燕，张晨，温玫，李昕，李尧华，蔡彦宁，陈彪，于顺*.a-突触核蛋白对MES23.5多巴胺能神经细胞的促增殖作用. 中国临床康复. 2006,10（10）:104-106.无
7. 张晨，李昕，李尧华，韩俊燕，陈彪，于顺*.细胞外a-突触核蛋白对MES23.5多巴胺能神经细胞的促增殖作用. 首都医科大学学报. 2006,27（5）:616-619.无
8. 董长松，李尧华*，刘师兵，王颖，李薇.小鼠脑14-3-3蛋白zeta亚型cDNA克隆及其原核表达分析. 神经解剖学杂志. 2006,22（5）:525-529.无
9. 李昕，李尧华，于顺*.锇酸固定组织的包埋后免疫电镜胶体金标记方法的改进. 基础医学与临床. 2006,26（6）:635-639.无
10. 高琳琳，李尧华*，吴燕川，于顺，陈彪.应用原核细胞表达法体外制备基因重组胰岛素降解酶的活性. 中国临床康复. 2005,9（31）:83-85.无
11. 李尧华，于顺，高亚萍，柳川，左晓虹，陈彪*.揭示a-突触核蛋白与帕金森病的关系：a-突触核蛋白单克隆抗体的研究. 中国临床康复. 2005,9（1）:44-46.无
12. 张晓录，于顺，张逢春，李尧华*.酪氨酸羟化酶与帕金森病. 中华临床医学杂志. 2005,6（2）:44-46.无
13. 史冬梅，陈彪，于顺，吴燕川，李尧华*.帕金森病相关基因重组型14-3-3蛋白与多巴胺代谢. 中国临床康复. 2005,9（17）:51-53.无
14. 张晓录，于顺，陈彪，张逢春，李尧华*.帕金森病病因蛋白质：a-突触核蛋白对酪氨酸羟化酶活性的影响. 中国临床康复. 2005,9（13）:34-36.无
15. 于泓，李尧华，冯秀丽，吴燕川，周虹，陈彪*.MES23.5细胞酪氨酸羟化酶种属来源及其重组酶的活性测定. 中国生物化学与分子生物学报. 2004,20（1）:95-100.无
16. Hisao Ueyama, Yao-Hua Li, Gui-Lian Fu, Patcharee Lertrit, La-ongsri Atchaneeyasakul, Sanae Oda,Shoko Tanabe, Yasuhiro Nishida, Shinichi Yamade, and Iwao Ohkubo*.An A-71C substitution in a green gene at the second position in the red/green vision-pigment gene array is associated with deutan color-vision deficiency. PNAS. 2003,100(6):3357-3362.SCI
17. Takehiro Chiba, Yao-Hua Li, Takuya Yamane, Osamu Ogikubo, Muneyoshi Fukuoka, Ryohachi Arai, Sho Takahashi, Takanobu Ohtsuka, Iwao Ohkubo*, Nobuo Matsui.Inhibition of recombinant dipeptidyl peptidase III by synthetic hemorphin-like. peptides. 2003,24:773-778.SCI
18. Takuya Yamane, Keisuke Takeuchi, Yoshio Yamamoto, Yao-Hua Li, Manabu Fujiwara, Katuji Nishi, Sho Takahashi, Iwao Ohkubo*.Legumain from bovin kidney: its purification, molecular cloning, immunohistochemical localization and degradation of annexin II and vitamin D-binding protein. Biochemical et Biophysica Acta. 2002,1596:108-120.SCI
19. Hisazumi Araki, Yao-Hua Li, Yoshio Yamamoto, Masakazu Haneda, Katsuji Nishi, Ryuichi KiKKawa, Iwao Ohkubo*.Purification, Molecular Cloning and Immunohistochemical Localization of DipeptidylPeptidase Ⅱ from the Rat Kidney and Its Identity with Quiescent Cell Proling Dipeptidase.. J.Biochem(Tokyo). 2001,129:279-288.SCI
20. Fumiaki Kamiyama,Tosinaga Maeda,Takuya Yamane,Yao-Hua Li,Osamu Ogukubo,Takanobu Otsuka,Hisao Ueyama,Sho Takahashi,Iwao Ohkubo,Nobuo Matsui*.Inhibition of Vitronectin-Mediated Haptotaxis and Haptoinvasion of MG-63 cell by Domain 5(D5H) of Human High-Molecular-Weight Kininogen and Identification of a Minimal Amino Acid Sequence.. Biochemical and Biophysical Research Communications. 2001,288:975-980.SCI
21. Yao-Hua Li, Toshinaga Maeda, Takuya Yamane, and Iwao Ohkubo*.Alteration of Rat Dipeptidyl Peptidase III by Site-Directed Mutagenesis:Cysteine176 is a Regulatory Residue for the Enzyme Activity.. Biochemical and Biophysical Research Communications. 2000,276:553-558.SCI
22. Iwao Ohkubo*,Yao-Hua Li,Toshinaga Maeda,Yoshio Yamamoto,Takuya Yamane,Pei-ge Du,Katsuji Nishi .Dipeptidyl Peptidase III from Rat Liver Cytosol:Purification,Molecular Cloning and Immunohistochemical Localization. Biological chemistry. 1999,380:1421-1430.SCI
23. Yoshio Yamamoto,Yao-Hua Li,Kai Huang,Iwao Ohkubo*,Katsuji Nishi .Isolation and Characterization of an Alanyl Aminopeptidase from Rat Liver Cytosol as a Puromycin-Sensitive Enkephalin-Degrading AminopeptidaseYoshio. Biological chemistry. 1998,379:711-719.SCI
24. YAOHUA LI,MASAFUMI KOGA,SOJI KASAYAMA,KEISHI MATSUMOTO, NORIO ARITA,TORU HAYAKAWA,BUNZO SATO*.Identification and Characterization of High Molecular Weight Forms of Basic Fibroblast Growth Factor in Human Pituitary Adenomas. Journal of Clinical Endocrinology and Metabolism. 1992,75(6):1436-1441.SCI
主编或副主编的著作/译著
重要奖项
职务： 招生院所：附属宣武医院
招生类型：科学学位(硕) 招生专业：神经生物学(硕)
研究方向名称：帕金森病相关蛋白质的功能与代谢
电子信箱：liyaohua@chinapd.cn
社会任职
个人简历
1. 197908-198408:吉林医学院医学系 学习
2. 198408-199609:吉林医学院医学系生物化学教研室 助教、讲师
3. 199010-199110:日本大阪大学医学部第三内科 留学
4. 199609-200103:日本滋贺医科大学代谢调节系生物化学第二讲座 博士课程
5. 200103-200303:首都医科大学宣武医院老年病研究所 博士后
6. 200303-200806:首都医科大学宣武医院老年病研究所 副研究员
重要学术论文
1. 刘光伟，殷娟娟，张春岩，李昕，刘耀波，李尧华，杨慧，陈彪，于顺*.a-突触核蛋白存在于大鼠脑线粒体中. 首都医科大学学报. 2007,28（3）:328-332.无
2. 李昕，于顺，李尧华*.重组大鼠a突触核蛋白的制备与鉴定. 首都医科大学学报. 2007,28（6）:333-336.无
3. 高楠，李尧华*，李昕，于顺，傅桂莲，陈彪.Effect of a-synuclein on the promoter activity of tyrosine hydroxylase gene. Neuroscience Bulletin. 2007,23(1):53-57.无
4. 殷娟娟，韩俊艳，李昕，李尧华，刘耀波，于顺*.a突触核蛋白功能片段向多巴胺能神经细胞内的转运及其对细胞增殖的影响. 首都医科大学学报. 2007,28（3）:345-349.无
5. 李昕，李尧华*，韩俊燕，于顺，陈彪.cDNA cloning, prokaryotic expression and purification of rat a-synuclein. Neuroscience Bulletin. 2006,22(1):29-33.无
6. 韩俊燕，张晨，温玫，李昕，李尧华，蔡彦宁，陈彪，于顺*.a-突触核蛋白对MES23.5多巴胺能神经细胞的促增殖作用. 中国临床康复. 2006,10（10）:104-106.无
7. 张晨，李昕，李尧华，韩俊燕，陈彪，于顺*.细胞外a-突触核蛋白对MES23.5多巴胺能神经细胞的促增殖作用. 首都医科大学学报. 2006,27（5）:616-619.无
8. 董长松，李尧华*，刘师兵，王颖，李薇.小鼠脑14-3-3蛋白zeta亚型cDNA克隆及其原核表达分析. 神经解剖学杂志. 2006,22（5）:525-529.无
9. 李昕，李尧华，于顺*.锇酸固定组织的包埋后免疫电镜胶体金标记方法的改进. 基础医学与临床. 2006,26（6）:635-639.无
10. 高琳琳，李尧华*，吴燕川，于顺，陈彪.应用原核细胞表达法体外制备基因重组胰岛素降解酶的活性. 中国临床康复. 2005,9（31）:83-85.无
11. 李尧华，于顺，高亚萍，柳川，左晓虹，陈彪*.揭示a-突触核蛋白与帕金森病的关系：a-突触核蛋白单克隆抗体的研究. 中国临床康复. 2005,9（1）:44-46.无
12. 张晓录，于顺，张逢春，李尧华*.酪氨酸羟化酶与帕金森病. 中华临床医学杂志. 2005,6（2）:44-46.无
13. 史冬梅，陈彪，于顺，吴燕川，李尧华*.帕金森病相关基因重组型14-3-3蛋白与多巴胺代谢. 中国临床康复. 2005,9（17）:51-53.无
14. 张晓录，于顺，陈彪，张逢春，李尧华*.帕金森病病因蛋白质：a-突触核蛋白对酪氨酸羟化酶活性的影响. 中国临床康复. 2005,9（13）:34-36.无
15. 于泓，李尧华，冯秀丽，吴燕川，周虹，陈彪*.MES23.5细胞酪氨酸羟化酶种属来源及其重组酶的活性测定. 中国生物化学与分子生物学报. 2004,20（1）:95-100.无
16. Hisao Ueyama, Yao-Hua Li, Gui-Lian Fu, Patcharee Lertrit, La-ongsri Atchaneeyasakul, Sanae Oda,Shoko Tanabe, Yasuhiro Nishida, Shinichi Yamade, and Iwao Ohkubo*.An A-71C substitution in a green gene at the second position in the red/green vision-pigment gene array is associated with deutan color-vision deficiency. PNAS. 2003,100(6):3357-3362.SCI
17. Takehiro Chiba, Yao-Hua Li, Takuya Yamane, Osamu Ogikubo, Muneyoshi Fukuoka, Ryohachi Arai, Sho Takahashi, Takanobu Ohtsuka, Iwao Ohkubo*, Nobuo Matsui.Inhibition of recombinant dipeptidyl peptidase III by synthetic hemorphin-like. peptides. 2003,24:773-778.SCI
18. Takuya Yamane, Keisuke Takeuchi, Yoshio Yamamoto, Yao-Hua Li, Manabu Fujiwara, Katuji Nishi, Sho Takahashi, Iwao Ohkubo*.Legumain from bovin kidney: its purification, molecular cloning, immunohistochemical localization and degradation of annexin II and vitamin D-binding protein. Biochemical et Biophysica Acta. 2002,1596:108-120.SCI
19. Hisazumi Araki, Yao-Hua Li, Yoshio Yamamoto, Masakazu Haneda, Katsuji Nishi, Ryuichi KiKKawa, Iwao Ohkubo*.Purification, Molecular Cloning and Immunohistochemical Localization of DipeptidylPeptidase Ⅱ from the Rat Kidney and Its Identity with Quiescent Cell Proling Dipeptidase.. J.Biochem(Tokyo). 2001,129:279-288.SCI
20. Fumiaki Kamiyama,Tosinaga Maeda,Takuya Yamane,Yao-Hua Li,Osamu Ogukubo,Takanobu Otsuka,Hisao Ueyama,Sho Takahashi,Iwao Ohkubo,Nobuo Matsui*.Inhibition of Vitronectin-Mediated Haptotaxis and Haptoinvasion of MG-63 cell by Domain 5(D5H) of Human High-Molecular-Weight Kininogen and Identification of a Minimal Amino Acid Sequence.. Biochemical and Biophysical Research Communications. 2001,288:975-980.SCI
21. Yao-Hua Li, Toshinaga Maeda, Takuya Yamane, and Iwao Ohkubo*.Alteration of Rat Dipeptidyl Peptidase III by Site-Directed Mutagenesis:Cysteine176 is a Regulatory Residue for the Enzyme Activity.. Biochemical and Biophysical Research Communications. 2000,276:553-558.SCI
22. Iwao Ohkubo*,Yao-Hua Li,Toshinaga Maeda,Yoshio Yamamoto,Takuya Yamane,Pei-ge Du,Katsuji Nishi .Dipeptidyl Peptidase III from Rat Liver Cytosol:Purification,Molecular Cloning and Immunohistochemical Localization. Biological chemistry. 1999,380:1421-1430.SCI
23. Yoshio Yamamoto,Yao-Hua Li,Kai Huang,Iwao Ohkubo*,Katsuji Nishi .Isolation and Characterization of an Alanyl Aminopeptidase from Rat Liver Cytosol as a Puromycin-Sensitive Enkephalin-Degrading AminopeptidaseYoshio. Biological chemistry. 1998,379:711-719.SCI
24. YAOHUA LI,MASAFUMI KOGA,SOJI KASAYAMA,KEISHI MATSUMOTO, NORIO ARITA,TORU HAYAKAWA,BUNZO SATO*.Identification and Characterization of High Molecular Weight Forms of Basic Fibroblast Growth Factor in Human Pituitary Adenomas. Journal of Clinical Endocrinology and Metabolism. 1992,75(6):1436-1441.SCI
主编或副主编的著作/译著
重要奖项
李尧华老师相关教学资源
