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陈富林老师介绍
陈富林，男，教授,副主任医师,博士生导师。1997年获硕士学位，2000年获口腔颌面外科专业博士学位。2006年开始在西北大学生命科学院工作，创建了西北大学组织工程中心，现任中心主任,教授，国际组织工程学会会员，Tissue Engineering,Journal of Biomedical Material and related Research两个刊物的审稿人。
以骨髓来源的成骨细胞作为种子细胞，以多孔滨珊瑚作为支架材料，以rhBMP2作为骨形成的促进因子，对骨缺损的修复情况和骨再造进行了系统的研究和观察，提出了多中心成骨方式促进骨缺损修复的观点。将金属引入组织工程支架材料中，成功进行钛网增强的组织工程骨的构建，可用于承力部位植骨。进行了负载牙种植体的组织工程骨的再造并获得成功，为用组织工程方法修复颌面部骨缺损，同时恢复患者咀嚼功能提供了基础。成功进行了注射型骨的再造研究，用这种方法再造骨组织具有微创和可反复进行的显著优越性。成功再造出了和骨-软骨复合组织，为进一步进行生物性关节头的再造打下基础。
主要个人学习和工作经历：
2006.10-今 西北大学生命科学院 教授，博士生导师
2004.12-2006.10 秦都口腔医学院颌面外科 副教授，副主任医师
2003.1-2004.12 新加坡国立大学工程学院， 研究员
2002-2003秦都口腔医学院颌面外科 副教授，副主任医师
2000-2002 秦都口腔医学院颌面外科 讲师，主治医师
1997.-2000. 秦都口腔医学院颌面外科 博士
1994.-1997.秦都口腔医学院颌面外科 硕士
1988.-1994.第四军医大学口腔医学系 大学
在研基金：
1．（2005）科技部中小企业创新基金-组织工程用可吸收羟基磷灰石－碳酸钙双相陶瓷人工骨 课题负责人
2．（2007）陕西省科技厅13115工程项目-基于细胞膜片技术的组织工程骨的研制与应用 课题负责人
3．（2008）国家自然科学基金面上项目-Chondromodulin 对骨髓基质细胞分化为软骨细胞稳定性的影响 课题负责人
获奖情况：
1．培养骨髓基质干细胞成骨能力的实验研究-获中华医学会西安分会青年优秀论文一等奖
2．Restoration of tissue engineered bone graft loading a titanium dental implant- Traveling Award of Chinese Division of IADR
3．The paper, “The effect of rhBMP-2 on canine osteoblasts seeded onto 3D bioactive
polycaprolactone scaffolds”, was awarded Best Paper in the 3rd Biomedical Engineering Society (Singapore) Symposium held on 21 May 2004, Ngee Ann Polytechnic.
4．羟基磷灰石－碳酸钙双相陶瓷人工骨（西安市科技进步二等奖）
Publications
1. Fulin Chen, Yefang Zhou, Saey Tuan Barnabas, Maria Ann Woodruff and Dietmar W. Hutmacher Engineering tubular bone constructs. Journal of Biomechanics, Volume 40, Supplement 1, 2007, Pages S73-S79
2. F. Chen, X. Feng, W. Wu, H. Ouyang, Z. Gao, X. Cheng, R. Hou, T. Mao.Segmental bone tissueengineering by seeding osteoblast precursor cells into titanium mesh–coral composite scaffolds. Int. J. Oral Maxillofac. Surg. 2007; 36: 822–827
3. Jie Zhao, Liang-Qi Liu, Ying-Juan Wang, Wei Yang, Wen-Xin Geng, Jing Wei, Li-Wen Li, Fu-Lin Chen. Treatment of alopecia by transplantation of hair follicle stem cells and dermal papilla cells encapsulated in alginate gels. Medical Hypotheses (2007), in press
4. Wei Wu, Fulin Chen, Xue Feng, Yanpu Liu, Tianqiu Mao. Engineering cartilage tissues with the shape of human nasal alar by using chondrocyte acroaggregate—Experiment study in rabbit model Journal of Biotechnology 130 (2007) 75–84
5. Wu W, Chen F, Liu Y, Ma Q, Mao T.Autologous Injectable Tissue-Engineered Cartilage by Using Platelet-Rich Plasma:Experimental Study in a Rabbit Model. J Oral Maxillofac Surg. 2007 Oct;65(10):1951-7
6. Mao-Guo Shu, Xiao-Tong Guo , Hai-Ning Zhen, Yan Han, Fu-Lin Chen, Li-Wen Li, Shu-Zhong Guo. Enhancing skin flap survival by a cell-permeable wild-type surviving. Medical Hypotheses (2007) 69, 888–891
7. Wei WU, Xiaobin CHEN, Tianqiu MAO, Fulin CHEN, Xinghua FENG
Bone marrow-derived osteoblasts seeded into porous beta-tricalciumphosphate to repair segmental defect in canine’s mandibula. Ulus Travma Acil Cerrahi Derg 2006;12(4):268-276
8. Hou R, Chen F, Yang Y, Cheng X, Gao Z, Yang HO, Wu W, Mao T. Comparative study between coral-mesenchymal stem cells-rhBMP-2 composite and auto-bone-graft in rabbit critical-sized cranial defect model。J Biomed Mater Res A. 2007 Jan;80(1):85-93
9. Wu W, Feng X, Mao T, Feng X, Ouyang HW, Zhao G, Chen F. Engineering of human tracheal tissue with collagen-enforced poly-lactic-glycolic acid non-woven mesh: A preliminary study in nude mice。Br J Oral Maxillofac Surg. (2007) 272–278
10. Fulin Chen，Hongwei Ouyang，Xue Feng, Zhan Gao, Yaowu Yang, Xiaohui Zou , Tieshan Liu , Guifang Zhao, Tianqiu Mao. Anchoring dental implant in tissue engineered bone with composite scaffold- a preliminary study in nude mouse model. J Oral Maxillofac Surg. 2005 May;63(5):586-91
11. Zhou Y, Chen F, Ho ST, Woodruff MA, Lim TM, Hutmacher DW. Combined marrow stromal cell-sheet techniques and high-strength biodegradable composite scaffolds for engineered functional bone grafts. Biomaterials. 2007 Feb;28(5):814-24
12. Fulin Chen., Shujun Chen, Kai Tao, Xue Feng, Yanpu Liu, Delin Lei,Tianqiu Mao . Marrow-derived osteoblasts seeded into porous natural coral to prefabricate a vascularised bone graft in the shape of a human mandibular ramus: experimental study in rabbits. British J of Oral and Maxillofacial Surgery, 2004，Dec (6): 537
13. Rai B, Teoh SH, Ho KH, Hutmacher DW, Cao T, Chen F, Yacob K. The effect of rhBMP-2 on canine osteoblasts seeded onto 3D bioactive polycaprolactone scaffolds. Biomaterials. 2004 Nov; 25(24):5499-506
14. Chen F, Mao T, Tao K, Chen S, Ding G, Gu X. Injectable bone. British J of Oral and Maxillofacial Surgery, 2003,41(4), 240-243
15. Chen F, Mao T, Tao K, Chen S, Ding G, Gu X. Bone graft in the shape of human mandibular condyle reconstruction via seeding marrow-derived osteoblasts into porous coral in a nude mice model. J Oral Maxillofac Surg. 2002;60(10):1155-9
16. Ma Q, Mao T, Liu B, Zhao J, Chen F, Wang H, Zhao M. Vascular osteomuscular autograft prefabrication using coral, type I collagen and recombinant human bone morphogenetic protein-2.Br J Oral Maxillofac Surg. 2000 ;38(5):561-4.
17. Yang WD, Chen SJ, Mao TQ, Chen FL, Lei DL, Tao K, Tang LH, Xiao MG.A study of injectable tissue-engineered autologous cartilage.Chin J Dent Res. 2000 Dec;3(4):10-5.
18. Chen F, Teoh SH, Hutmacher DW. The relation between substrate stiffness and chondrocyte proliferation. 2003-6th International Conference of Tissue Engineering. Orlando, USA
19. Chen F, Teoh SH, Hutmacher DW. Stiffness of polycaprolactone influences chondrocyte proliferation.2004-7th World Biomaterials Congress Sydney Convention & Exhibition Centre,Darling Harbour, Sydney, Australia
20. Chen F, Teoh SH, Hutmacher DW, Mao TQ, Ouyang HW. Fabrication of novel scaffold from cuttle boen for bone tissue engineering. 2004-7th World Biomaterials Congress Sydney Convention & Exhibition Centre,Darling Harbour, Sydney, Australia
以骨髓来源的成骨细胞作为种子细胞，以多孔滨珊瑚作为支架材料，以rhBMP2作为骨形成的促进因子，对骨缺损的修复情况和骨再造进行了系统的研究和观察，提出了多中心成骨方式促进骨缺损修复的观点。将金属引入组织工程支架材料中，成功进行钛网增强的组织工程骨的构建，可用于承力部位植骨。进行了负载牙种植体的组织工程骨的再造并获得成功，为用组织工程方法修复颌面部骨缺损，同时恢复患者咀嚼功能提供了基础。成功进行了注射型骨的再造研究，用这种方法再造骨组织具有微创和可反复进行的显著优越性。成功再造出了和骨-软骨复合组织，为进一步进行生物性关节头的再造打下基础。
主要个人学习和工作经历：
2006.10-今 西北大学生命科学院 教授，博士生导师
2004.12-2006.10 秦都口腔医学院颌面外科 副教授，副主任医师
2003.1-2004.12 新加坡国立大学工程学院， 研究员
2002-2003秦都口腔医学院颌面外科 副教授，副主任医师
2000-2002 秦都口腔医学院颌面外科 讲师，主治医师
1997.-2000. 秦都口腔医学院颌面外科 博士
1994.-1997.秦都口腔医学院颌面外科 硕士
1988.-1994.第四军医大学口腔医学系 大学
在研基金：
1．（2005）科技部中小企业创新基金-组织工程用可吸收羟基磷灰石－碳酸钙双相陶瓷人工骨 课题负责人
2．（2007）陕西省科技厅13115工程项目-基于细胞膜片技术的组织工程骨的研制与应用 课题负责人
3．（2008）国家自然科学基金面上项目-Chondromodulin 对骨髓基质细胞分化为软骨细胞稳定性的影响 课题负责人
获奖情况：
1．培养骨髓基质干细胞成骨能力的实验研究-获中华医学会西安分会青年优秀论文一等奖
2．Restoration of tissue engineered bone graft loading a titanium dental implant- Traveling Award of Chinese Division of IADR
3．The paper, “The effect of rhBMP-2 on canine osteoblasts seeded onto 3D bioactive
polycaprolactone scaffolds”, was awarded Best Paper in the 3rd Biomedical Engineering Society (Singapore) Symposium held on 21 May 2004, Ngee Ann Polytechnic.
4．羟基磷灰石－碳酸钙双相陶瓷人工骨（西安市科技进步二等奖）
Publications
1. Fulin Chen, Yefang Zhou, Saey Tuan Barnabas, Maria Ann Woodruff and Dietmar W. Hutmacher Engineering tubular bone constructs. Journal of Biomechanics, Volume 40, Supplement 1, 2007, Pages S73-S79
2. F. Chen, X. Feng, W. Wu, H. Ouyang, Z. Gao, X. Cheng, R. Hou, T. Mao.Segmental bone tissueengineering by seeding osteoblast precursor cells into titanium mesh–coral composite scaffolds. Int. J. Oral Maxillofac. Surg. 2007; 36: 822–827
3. Jie Zhao, Liang-Qi Liu, Ying-Juan Wang, Wei Yang, Wen-Xin Geng, Jing Wei, Li-Wen Li, Fu-Lin Chen. Treatment of alopecia by transplantation of hair follicle stem cells and dermal papilla cells encapsulated in alginate gels. Medical Hypotheses (2007), in press
4. Wei Wu, Fulin Chen, Xue Feng, Yanpu Liu, Tianqiu Mao. Engineering cartilage tissues with the shape of human nasal alar by using chondrocyte acroaggregate—Experiment study in rabbit model Journal of Biotechnology 130 (2007) 75–84
5. Wu W, Chen F, Liu Y, Ma Q, Mao T.Autologous Injectable Tissue-Engineered Cartilage by Using Platelet-Rich Plasma:Experimental Study in a Rabbit Model. J Oral Maxillofac Surg. 2007 Oct;65(10):1951-7
6. Mao-Guo Shu, Xiao-Tong Guo , Hai-Ning Zhen, Yan Han, Fu-Lin Chen, Li-Wen Li, Shu-Zhong Guo. Enhancing skin flap survival by a cell-permeable wild-type surviving. Medical Hypotheses (2007) 69, 888–891
7. Wei WU, Xiaobin CHEN, Tianqiu MAO, Fulin CHEN, Xinghua FENG
Bone marrow-derived osteoblasts seeded into porous beta-tricalciumphosphate to repair segmental defect in canine’s mandibula. Ulus Travma Acil Cerrahi Derg 2006;12(4):268-276
8. Hou R, Chen F, Yang Y, Cheng X, Gao Z, Yang HO, Wu W, Mao T. Comparative study between coral-mesenchymal stem cells-rhBMP-2 composite and auto-bone-graft in rabbit critical-sized cranial defect model。J Biomed Mater Res A. 2007 Jan;80(1):85-93
9. Wu W, Feng X, Mao T, Feng X, Ouyang HW, Zhao G, Chen F. Engineering of human tracheal tissue with collagen-enforced poly-lactic-glycolic acid non-woven mesh: A preliminary study in nude mice。Br J Oral Maxillofac Surg. (2007) 272–278
10. Fulin Chen，Hongwei Ouyang，Xue Feng, Zhan Gao, Yaowu Yang, Xiaohui Zou , Tieshan Liu , Guifang Zhao, Tianqiu Mao. Anchoring dental implant in tissue engineered bone with composite scaffold- a preliminary study in nude mouse model. J Oral Maxillofac Surg. 2005 May;63(5):586-91
11. Zhou Y, Chen F, Ho ST, Woodruff MA, Lim TM, Hutmacher DW. Combined marrow stromal cell-sheet techniques and high-strength biodegradable composite scaffolds for engineered functional bone grafts. Biomaterials. 2007 Feb;28(5):814-24
12. Fulin Chen., Shujun Chen, Kai Tao, Xue Feng, Yanpu Liu, Delin Lei,Tianqiu Mao . Marrow-derived osteoblasts seeded into porous natural coral to prefabricate a vascularised bone graft in the shape of a human mandibular ramus: experimental study in rabbits. British J of Oral and Maxillofacial Surgery, 2004，Dec (6): 537
13. Rai B, Teoh SH, Ho KH, Hutmacher DW, Cao T, Chen F, Yacob K. The effect of rhBMP-2 on canine osteoblasts seeded onto 3D bioactive polycaprolactone scaffolds. Biomaterials. 2004 Nov; 25(24):5499-506
14. Chen F, Mao T, Tao K, Chen S, Ding G, Gu X. Injectable bone. British J of Oral and Maxillofacial Surgery, 2003,41(4), 240-243
15. Chen F, Mao T, Tao K, Chen S, Ding G, Gu X. Bone graft in the shape of human mandibular condyle reconstruction via seeding marrow-derived osteoblasts into porous coral in a nude mice model. J Oral Maxillofac Surg. 2002;60(10):1155-9
16. Ma Q, Mao T, Liu B, Zhao J, Chen F, Wang H, Zhao M. Vascular osteomuscular autograft prefabrication using coral, type I collagen and recombinant human bone morphogenetic protein-2.Br J Oral Maxillofac Surg. 2000 ;38(5):561-4.
17. Yang WD, Chen SJ, Mao TQ, Chen FL, Lei DL, Tao K, Tang LH, Xiao MG.A study of injectable tissue-engineered autologous cartilage.Chin J Dent Res. 2000 Dec;3(4):10-5.
18. Chen F, Teoh SH, Hutmacher DW. The relation between substrate stiffness and chondrocyte proliferation. 2003-6th International Conference of Tissue Engineering. Orlando, USA
19. Chen F, Teoh SH, Hutmacher DW. Stiffness of polycaprolactone influences chondrocyte proliferation.2004-7th World Biomaterials Congress Sydney Convention & Exhibition Centre,Darling Harbour, Sydney, Australia
20. Chen F, Teoh SH, Hutmacher DW, Mao TQ, Ouyang HW. Fabrication of novel scaffold from cuttle boen for bone tissue engineering. 2004-7th World Biomaterials Congress Sydney Convention & Exhibition Centre,Darling Harbour, Sydney, Australia
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