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郑熙隆老师介绍
郑熙隆 特聘教授 博士生导师
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学历
1998-2001博士后（加拿大卡尔加里大学）生化及分子生物学，导师: Dr. Norman C.W. Wong
1997-1998 博士后（美国纽约州立大学－长岛）分子药理，导师: Dr. Craig C. Malbon
1993-1997 博士（加拿大卡尔加里大学）导师: Dr. Morley D. Hollenberg
1989-1992 广东省心研所内科住院医生 导师: 林曙光
1986-1989 药理硕士湖南医学医学院 导师: 严幼芳
1981-1986 湖南医学院医疗系
工作经历
2007－至今南开大学医学院教授，博导，副院长
2001- 2007 加拿大卡尔加里大学助理教授/副教授
1992-1993 广东省心研所内科主治医生
主要研究领域与方向
郑熙隆教授的科研兴趣是血管病理及生物学。着重探讨血管平滑肌分化和去分化的机理及其在动脉粥样硬化及高血压等发病中的作用。主要研究手段包括分子生物学及细胞生物学等技术。
研究项目
2008-2011 国家自然科学基金 四磷酸脲腺苷对血管平滑肌及动脉粥样硬化的作用
2008-2011 天津市应用基础及前沿技术研究计划重点项目 雌激素代谢产物2ME治疗动脉粥样硬化的研究
2007-2011 南开大学启动金费 血管平滑肌细胞增生以及动脉粥样硬化发病机制的研究
近年主要论文：
2009 Shin E.L., Zheng X.L. and Sweeney G. Leptin attenuates hypoxia/reoxygenation-induced activation of the intrinsic pathway of apoptosis in rat H9c2 cells. Journal of Cellular Physiology (In press)
2008 Gui Y., Zheng X.L., Zheng J. and Walsh, M.P. Inhibition of rat aortic smooth muscle contraction by 2-methoxyestradiol. American Journal of Physiology: Heart and Circulatory Physiology 295: H1935-42
2008 Gui Y., Michael P. Walsh, M.P.§, Jankowski, V., Jankowski, J. and Zheng, X.L§. Up4A stimulates endothelium-independent contraction of isolated rat pulmonary. American Journal of Physiology: Lung Cellular and Molecular Physiology 294: L733-8
§ Corresponding author
2008 Tang R*, Zheng, X.L.*, Callis, T.E., Stans.eld, W.E., He, J., Baldwin, A.S. and Wang, D.Z. and Selzman, C.H. Myocardin inhibits cellular proliferation by inhibiting NF-κB(p65)-dependent cell cycle progression. Proceedings of the National Academy of Sciences USA 105: 3362-3367. * Equal contribution
2007 Gui, Y., He, G., Walsh, M.P. and Zheng, X.L.§ Predisposition to tetraploidy in pulmonary vascular smooth muscle cells derived from the Eker rats. American Journal of Physiology: Lung Cellular and Molecular Physiology 293: L702-711. Corresponding author
2007 Corteling, R., Brett, S., Hao, Y., Zheng, X.L. Walsh, M. and Welsh, D. The functional consequence of RhoA knockdown by RNA interference in rat cerebral arteries. American Journal of Physiology: Heart and Circulatory Physiology 292: H440-7.
2007 Jankowski, V., Meyer, A., Schlattmann, P., Gui, Y., Zheng, X.L., Stamcou, I., Radtke, K., AnhTran, T., van der Giet, M., Zidek, W. and Jankowski, J. Increased uridine adenosine tetraphosphate concentrations in plasma of juvenile hypertensives. Arteriosclerosis, Thrombosis, and Vascular Biology 27: 1776-81.
2007 Zheng, X.L.§, Yuan, S. and Peng, D.Q. The phenotype-specific effects of high glucose on vascular smooth muscle cells. Diabetologia 50: 881–890. § Corresponding author
2007 Gui, Y., Yin, H., He, J., Yang, S., Walsh, M.P. and Zheng, X.L.§ Endoreduplication of human smooth muscle cells induced by 2-methoxyestradiol: a role for cyclin-dependent kinase 2. American Journal of Physiology: Heart and Circulatory Physiology 292: H1313-H1320. § Corresponding author
2006 Zheng, X.L.§ and Wong, N. C. W. Cyclosporine A inhibits apolipoprotein AI gene expression. Journal of Molecular Endocrinology 37: 367-373. § Corresponding author
2006 Gui, Y. and Zheng, X.L.§ 2-Methoxyestradiol induces cell cycle arrest and mitotic cell apoptosis in human vascular smooth muscle cells. Hypertension 47: 271-280.§ Corresponding author
2004 Zheng, X.L.§, Gui, Y., Du, G., Frohman, M.A. and Peng, D.Q. Calphostin-C induction of vascular smooth muscle cell apoptosis proceeds through phospholipase D and microtubule inhibition. Journal of Biological Chemistry 279: 7112-7118. § Corresponding author
2003 Gui, Y. and Zheng, X.L.§ Epidermal growth factor induction of phenotype-dependent cell cycle arrest in vascular smooth muscle cells is through the mitogen-activated protein kinase pathway. Journal of Biological Chemistry 278: 53017-53025. § Corresponding author
2003 Lam, J.K., Matsubara, S., Mihara, K., Zheng, X.L., Mooradian, A.D. and Wong, N.C.W. Insulin induction of apolipoprotein AI, role of Sp1. Biochemistry 42: 2680-2690.
2001 Song, X., Zheng, X. L., Malbon, C. C. and Wang, H.Y. Gia2 enhances in vivo activation of and insulin signaling to GLUT4. Journal of Biological Chemistry 276: 34651-34658.
2001 Zheng, X. L., Matsubara, S., Diao, C., Hollenberg, M. D. and Wong, N. C. W. Epidermal growth factor induction of apolipoprotein AI is mediated by the Ras-MAP kinase cascade and Sp1. Journal of Biological Chemistry 276: 13822-13829.
2000 Zheng, X. L., Matsubara, S., Diao, C., Hollenberg, M. D. and Wong, N. C. W. Activation of apolipoprotein AI gene expression by protein kinase A and kinase C through transcription factor, Sp1. Journal of Biological Chemistry 275: 31747-31754.
2000 Gui, Y., Zheng, X. L. and Hollenberg, M. D. Interleukin-1β, Src-and non-Src tyrosine kinases, and nitric oxide synthase induction in rat aorta in vivo. American Journal of Physiology 279: H566-H576.
1999 Zheng, X. L., Gui, Y., Sharkey, K. A. and Hollenberg, M. D. Differential induction of nitric oxide synthase in rat gastric and vascular smooth muscle tissue: distinct tissue distribution and distinctive signaling pathways. Journal of Pharmacology & Experimental Therapeutics 289: 632-640.
1998 Zheng, X. L., Renaux, B. and Hollenberg, M. D. Parallel contractile signal transduction pathways activated by receptors for thrombin and epidermal growth factor-urogastrone in guinea pig gastric smooth muscle: blockade by inhibitors of mitogen-activated protein kinase-kinase and phosphatidyl inositol 3'-kinase. Journal of Pharmacology & Experimental Therapeutics 285: 325-334.
1998 Zheng, X. L., Guo, J., Wang, H.Y. and Malbon, C. C. Expression of constitutively activated Gialpha2 in vivo ameliorates streptozotocin-induced diabetes. Journal of Biological Chemistry 273: 23649-23651.
1997 Zheng, X. L. and Hollenberg, M. D. Tyrosine kinase inhibitor-sensitive contractile action of ethanol in gastric smooth muscle: comparison with the action of epidermal growth factor. Proceedings of the Association of American Physicians 109: 78-83.
1997 Zheng, X. L., Mokashi, S. and Hollenberg, M. D. Contractile action of ethanol in guinea pig gastric smooth muscle: inhibition by tyrosine kinase inhibitors and comparison with the contractile action of epidermal growth factor-urogastrone. Journal of Pharmacology & Experimental Therapeutics 282: 485-495.
1997 Zheng, X. L., Sharkey, K. A. and Hollenberg, M. D. Induction of nitric oxide synthase in ratgastric smooth muscle preparations. American Journal of Physiology 273: G1101-G1107.
1993Lin, S. G., Zheng, X. L.§, Chen, Q. Y. and Sun, J. J. Effect of Panax notoginseng saponins onincreased proliferation of cultured aortic smooth muscle cells stimulated by hypercholesterolemic serum.Chung-Kuo Yao Li Hsueh Pao - Acta Pharmacologica Sinica 14: 314-316.§ Corresponding author
Chinese Publications
1993 Zheng, X.L. Molecular pharmacology: advance of calcium channel. Guowai Yixue 13:26-27.
1991 Zheng, X.L. and Yan, Y.F. Effect of Gensenosides on the regulation of lipids and anti-peroxidationin chronic hyperlipidemic rabbits. Chinese Pharmacological Bulletin 7:110-113.
1991 Zheng, X.L., Wu, J.X. and Yan, Y.F. Effect of Gensenosides of stems and leaves on PGF2alpha/TXB2 of hyperlipidemic rabbits. Bulletin of Hunan Medical University 16:407-409.
Extended Abstract
1997 Zheng, X.L. and Hollenberg, M.D. Dependence of thrombin receptor-mediated contraction of guinea pig gastric smooth muscle on growth factor signaling pathways: comparison with EGF and implication of a role for Src-family kinases. Proceedings of the Western Pharmacological Society 40:45-48.
联系方式：
地址：南开大学医学院心血管细胞生物学与分子生物学研究室
天津市南开区卫津路94号（300071）
电话：86-22-23509842
传真：86-22-23509842
Email：xlzheng@ucalgary.ca
--------------------------------------------------------------------------------
学历
1998-2001博士后（加拿大卡尔加里大学）生化及分子生物学，导师: Dr. Norman C.W. Wong
1997-1998 博士后（美国纽约州立大学－长岛）分子药理，导师: Dr. Craig C. Malbon
1993-1997 博士（加拿大卡尔加里大学）导师: Dr. Morley D. Hollenberg
1989-1992 广东省心研所内科住院医生 导师: 林曙光
1986-1989 药理硕士湖南医学医学院 导师: 严幼芳
1981-1986 湖南医学院医疗系
工作经历
2007－至今南开大学医学院教授，博导，副院长
2001- 2007 加拿大卡尔加里大学助理教授/副教授
1992-1993 广东省心研所内科主治医生
主要研究领域与方向
郑熙隆教授的科研兴趣是血管病理及生物学。着重探讨血管平滑肌分化和去分化的机理及其在动脉粥样硬化及高血压等发病中的作用。主要研究手段包括分子生物学及细胞生物学等技术。
研究项目
2008-2011 国家自然科学基金 四磷酸脲腺苷对血管平滑肌及动脉粥样硬化的作用
2008-2011 天津市应用基础及前沿技术研究计划重点项目 雌激素代谢产物2ME治疗动脉粥样硬化的研究
2007-2011 南开大学启动金费 血管平滑肌细胞增生以及动脉粥样硬化发病机制的研究
近年主要论文：
2009 Shin E.L., Zheng X.L. and Sweeney G. Leptin attenuates hypoxia/reoxygenation-induced activation of the intrinsic pathway of apoptosis in rat H9c2 cells. Journal of Cellular Physiology (In press)
2008 Gui Y., Zheng X.L., Zheng J. and Walsh, M.P. Inhibition of rat aortic smooth muscle contraction by 2-methoxyestradiol. American Journal of Physiology: Heart and Circulatory Physiology 295: H1935-42
2008 Gui Y., Michael P. Walsh, M.P.§, Jankowski, V., Jankowski, J. and Zheng, X.L§. Up4A stimulates endothelium-independent contraction of isolated rat pulmonary. American Journal of Physiology: Lung Cellular and Molecular Physiology 294: L733-8
§ Corresponding author
2008 Tang R*, Zheng, X.L.*, Callis, T.E., Stans.eld, W.E., He, J., Baldwin, A.S. and Wang, D.Z. and Selzman, C.H. Myocardin inhibits cellular proliferation by inhibiting NF-κB(p65)-dependent cell cycle progression. Proceedings of the National Academy of Sciences USA 105: 3362-3367. * Equal contribution
2007 Gui, Y., He, G., Walsh, M.P. and Zheng, X.L.§ Predisposition to tetraploidy in pulmonary vascular smooth muscle cells derived from the Eker rats. American Journal of Physiology: Lung Cellular and Molecular Physiology 293: L702-711. Corresponding author
2007 Corteling, R., Brett, S., Hao, Y., Zheng, X.L. Walsh, M. and Welsh, D. The functional consequence of RhoA knockdown by RNA interference in rat cerebral arteries. American Journal of Physiology: Heart and Circulatory Physiology 292: H440-7.
2007 Jankowski, V., Meyer, A., Schlattmann, P., Gui, Y., Zheng, X.L., Stamcou, I., Radtke, K., AnhTran, T., van der Giet, M., Zidek, W. and Jankowski, J. Increased uridine adenosine tetraphosphate concentrations in plasma of juvenile hypertensives. Arteriosclerosis, Thrombosis, and Vascular Biology 27: 1776-81.
2007 Zheng, X.L.§, Yuan, S. and Peng, D.Q. The phenotype-specific effects of high glucose on vascular smooth muscle cells. Diabetologia 50: 881–890. § Corresponding author
2007 Gui, Y., Yin, H., He, J., Yang, S., Walsh, M.P. and Zheng, X.L.§ Endoreduplication of human smooth muscle cells induced by 2-methoxyestradiol: a role for cyclin-dependent kinase 2. American Journal of Physiology: Heart and Circulatory Physiology 292: H1313-H1320. § Corresponding author
2006 Zheng, X.L.§ and Wong, N. C. W. Cyclosporine A inhibits apolipoprotein AI gene expression. Journal of Molecular Endocrinology 37: 367-373. § Corresponding author
2006 Gui, Y. and Zheng, X.L.§ 2-Methoxyestradiol induces cell cycle arrest and mitotic cell apoptosis in human vascular smooth muscle cells. Hypertension 47: 271-280.§ Corresponding author
2004 Zheng, X.L.§, Gui, Y., Du, G., Frohman, M.A. and Peng, D.Q. Calphostin-C induction of vascular smooth muscle cell apoptosis proceeds through phospholipase D and microtubule inhibition. Journal of Biological Chemistry 279: 7112-7118. § Corresponding author
2003 Gui, Y. and Zheng, X.L.§ Epidermal growth factor induction of phenotype-dependent cell cycle arrest in vascular smooth muscle cells is through the mitogen-activated protein kinase pathway. Journal of Biological Chemistry 278: 53017-53025. § Corresponding author
2003 Lam, J.K., Matsubara, S., Mihara, K., Zheng, X.L., Mooradian, A.D. and Wong, N.C.W. Insulin induction of apolipoprotein AI, role of Sp1. Biochemistry 42: 2680-2690.
2001 Song, X., Zheng, X. L., Malbon, C. C. and Wang, H.Y. Gia2 enhances in vivo activation of and insulin signaling to GLUT4. Journal of Biological Chemistry 276: 34651-34658.
2001 Zheng, X. L., Matsubara, S., Diao, C., Hollenberg, M. D. and Wong, N. C. W. Epidermal growth factor induction of apolipoprotein AI is mediated by the Ras-MAP kinase cascade and Sp1. Journal of Biological Chemistry 276: 13822-13829.
2000 Zheng, X. L., Matsubara, S., Diao, C., Hollenberg, M. D. and Wong, N. C. W. Activation of apolipoprotein AI gene expression by protein kinase A and kinase C through transcription factor, Sp1. Journal of Biological Chemistry 275: 31747-31754.
2000 Gui, Y., Zheng, X. L. and Hollenberg, M. D. Interleukin-1β, Src-and non-Src tyrosine kinases, and nitric oxide synthase induction in rat aorta in vivo. American Journal of Physiology 279: H566-H576.
1999 Zheng, X. L., Gui, Y., Sharkey, K. A. and Hollenberg, M. D. Differential induction of nitric oxide synthase in rat gastric and vascular smooth muscle tissue: distinct tissue distribution and distinctive signaling pathways. Journal of Pharmacology & Experimental Therapeutics 289: 632-640.
1998 Zheng, X. L., Renaux, B. and Hollenberg, M. D. Parallel contractile signal transduction pathways activated by receptors for thrombin and epidermal growth factor-urogastrone in guinea pig gastric smooth muscle: blockade by inhibitors of mitogen-activated protein kinase-kinase and phosphatidyl inositol 3'-kinase. Journal of Pharmacology & Experimental Therapeutics 285: 325-334.
1998 Zheng, X. L., Guo, J., Wang, H.Y. and Malbon, C. C. Expression of constitutively activated Gialpha2 in vivo ameliorates streptozotocin-induced diabetes. Journal of Biological Chemistry 273: 23649-23651.
1997 Zheng, X. L. and Hollenberg, M. D. Tyrosine kinase inhibitor-sensitive contractile action of ethanol in gastric smooth muscle: comparison with the action of epidermal growth factor. Proceedings of the Association of American Physicians 109: 78-83.
1997 Zheng, X. L., Mokashi, S. and Hollenberg, M. D. Contractile action of ethanol in guinea pig gastric smooth muscle: inhibition by tyrosine kinase inhibitors and comparison with the contractile action of epidermal growth factor-urogastrone. Journal of Pharmacology & Experimental Therapeutics 282: 485-495.
1997 Zheng, X. L., Sharkey, K. A. and Hollenberg, M. D. Induction of nitric oxide synthase in ratgastric smooth muscle preparations. American Journal of Physiology 273: G1101-G1107.
1993Lin, S. G., Zheng, X. L.§, Chen, Q. Y. and Sun, J. J. Effect of Panax notoginseng saponins onincreased proliferation of cultured aortic smooth muscle cells stimulated by hypercholesterolemic serum.Chung-Kuo Yao Li Hsueh Pao - Acta Pharmacologica Sinica 14: 314-316.§ Corresponding author
Chinese Publications
1993 Zheng, X.L. Molecular pharmacology: advance of calcium channel. Guowai Yixue 13:26-27.
1991 Zheng, X.L. and Yan, Y.F. Effect of Gensenosides on the regulation of lipids and anti-peroxidationin chronic hyperlipidemic rabbits. Chinese Pharmacological Bulletin 7:110-113.
1991 Zheng, X.L., Wu, J.X. and Yan, Y.F. Effect of Gensenosides of stems and leaves on PGF2alpha/TXB2 of hyperlipidemic rabbits. Bulletin of Hunan Medical University 16:407-409.
Extended Abstract
1997 Zheng, X.L. and Hollenberg, M.D. Dependence of thrombin receptor-mediated contraction of guinea pig gastric smooth muscle on growth factor signaling pathways: comparison with EGF and implication of a role for Src-family kinases. Proceedings of the Western Pharmacological Society 40:45-48.
联系方式：
地址：南开大学医学院心血管细胞生物学与分子生物学研究室
天津市南开区卫津路94号（300071）
电话：86-22-23509842
传真：86-22-23509842
Email：xlzheng@ucalgary.ca
郑熙隆老师相关教学资源
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